7-carboxamide-6-N-phenylamino-3,4-dihydrothieno[3,2-d]-pyrimidine | 1095704-87-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并嘧啶酮衍生物
• 英文名称: 7-carboxamide-6-N-phenylamino-3,4-dihydrothieno[3,2-d]-pyrimidine
• 英文别名: 6-anilino-4-oxo-3H-thieno[3,2-d]pyrimidine-7-carboxamide
• CAS: 1095704-87-2
• 化学式: C₁₃H₁₀N₄O₂S
• 分子量: 286.314
• InChiKey: KGQGDTLHHHTELU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  125
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  甲酸 、 3-amino-4-cyano-5-phenylaminothiophene-2-carboxamide 反应 6.0h， 以85%的产率得到7-carboxamide-6-N-phenylamino-3,4-dihydrothieno[3,2-d]-pyrimidine
  参考文献：
  名称：

  Heterocyclic Synthesis with Thiophene-2-Carboxamide

  摘要：

  3-Amino-4-cyano-N-phenylaminothiophene-2-carboxamide (2) was prepared by reacting 2-(1,1-dicyanomethylene)-3-N-phenyl-1,3-thiazolidin-4-one (1) with ammonia. The carboxamide when reacted with benzaldehyde, formic acid, phenylisothiocyanate, cyclohexanone, cyclopentanone, ethylchloroformate and carbon disulfide yield. The pyrimidinone derivatives (3, 4, 5, 6, 7, 8, and 9), respectively. The biological activity of all synthesized compounds were studied as antibiotics and against Grain positive and Gram negative bacteria. The purpose of this article is synthesis of new antibiotic and antibacterial drugs.

  DOI：

  10.1080/10426500701557005

文献信息

• Heterocyclic Synthesis with Thiophene-2-Carboxamide
  作者：Gamal A. Ahmed

  DOI：10.1080/10426500701557005

  日期：2007.12.24

  3-Amino-4-cyano-N-phenylaminothiophene-2-carboxamide (2) was prepared by reacting 2-(1,1-dicyanomethylene)-3-N-phenyl-1,3-thiazolidin-4-one (1) with ammonia. The carboxamide when reacted with benzaldehyde, formic acid, phenylisothiocyanate, cyclohexanone, cyclopentanone, ethylchloroformate and carbon disulfide yield. The pyrimidinone derivatives (3, 4, 5, 6, 7, 8, and 9), respectively. The biological activity of all synthesized compounds were studied as antibiotics and against Grain positive and Gram negative bacteria. The purpose of this article is synthesis of new antibiotic and antibacterial drugs.