4,1'-Dimethyl-spiro<<1,3>dioxolan-2.4'-piperidin> | 80477-45-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: 4,1'-Dimethyl-spiro<<1,3>dioxolan-2.4'-piperidin>
• 英文别名: 2,8-dimethyl-1,4-dioxa-8-aza-spiro[4.5]decane；3,8-Dimethyl-1,4-dioxa-8-azaspiro[4.5]decane
• CAS: 80477-45-8
• 化学式: C₉H₁₇NO₂
• 分子量: 171.239
• InChiKey: HGJNDSVLPGSHRL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  碘甲烷 、 4,1'-Dimethyl-spiro<<1,3>dioxolan-2.4'-piperidin> 以 丙酮 为溶剂， 以80.3%的产率得到4,1',1'-Trimethyl-spiro<<1,3>dioxolan-2.4'-piperidinium>
  参考文献：
  名称：

  Synthesis and selective activity of cholinergic agents with rigid skeletons. II.

  摘要：

  三种类型的化合物（喹宁环-3-螺-2'-二氧六环（A）、哌啶-4-螺-2'-二氧六环（B）和哌啶-4-螺-2'-(4'-氧二氧六环)（C））及其甲碘化物被合成。为了研究这些具有刚性骨架的化合物与已知毒蕈碱样作用剂之间活性的关系，对其胆碱能样活性进行了检验。

  DOI：

  10.1248/cpb.29.3019
• 作为产物：
  描述：

  1,2-丙二醇 、 1-甲基-4-哌啶酮盐酸盐 生成 4,1'-Dimethyl-spiro<<1,3>dioxolan-2.4'-piperidin>
  参考文献：
  名称：

  1-甲基-4-哌啶酮和肌钙蛋白的缩酮和半硫缩酮。

  摘要：

  DOI：

  10.1002/jps.2600500606

文献信息

• TAKEMURA, SHOJI;MIKI, YASUYOSHI;HOSHIDA, MARIKO;SHIBANO, MAYUMI;SUZUKI, A+, CHEM. AND PHARM. BULL., 1981, 29, N 10, 3019-3025
  作者：TAKEMURA, SHOJI、MIKI, YASUYOSHI、HOSHIDA, MARIKO、SHIBANO, MAYUMI、SUZUKI, A+

  DOI：——

  日期：——
• New antimicrobial compounds, their use for the treatment of mammalian infections and a new metabolic mechanism
  申请人：Leibniz-institut für Naturstoff-Forschung und Infe Infektionsbiologie E.V. Hans-Knöll Institut (HKI)

  公开号：US20200407351A1

  公开（公告）日：2020-12-31

  The present invention relates to the general field of treatment of infectious diseases of mammals (humans and animals) caused by bacteria, in particular to the treatment of diseases like tuberculosis (TB), Buruli ulcer and leprosy caused by mycobacteria. The invention aims at the generation of a new series of benzothiazinone compounds having the potential to overcome the above mentioned problems. The invention is in a preferred embodiment concerned with compounds of the general formula (I), wherein the substituents R 1 to R 15 have the meanings as provided in claim 1 and depending claims.
• Synthesis and selective activity of cholinergic agents with rigid skeletons. II.
  作者：SHOJI TAKEMURA、YASUYOSHI MIKI、MARIKO HOSHIDA、MAYUMI SHIBANO、ARITOMO SUZUKI

  DOI：10.1248/cpb.29.3019

  日期：——

  Three types of compound, quinuclidine-3-spiro-2'-dioxolane (A), piperidine-4-spiro-2'-dioxolane (B), and piperidine-4-spiro-2'-(4'-oxodioxolane) (C) and their methiodides were synthesized. The cholinomimetic activities of these compounds were examined to investigate the relationship between the activities of these compounds, which have rigid skeletons, and those of known muscarinic agents.

  三种类型的化合物（喹宁环-3-螺-2'-二氧六环（A）、哌啶-4-螺-2'-二氧六环（B）和哌啶-4-螺-2'-(4'-氧二氧六环)（C））及其甲碘化物被合成。为了研究这些具有刚性骨架的化合物与已知毒蕈碱样作用剂之间活性的关系，对其胆碱能样活性进行了检验。
• Ketals and Hemithioketals of 1-Methyl-4-piperidone and Tropinone
  作者：Mathias P. Mertes、Ole Gisvold

  DOI：10.1002/jps.2600500606

  日期：1961.6