2-[(4-chlorophenyl)methylidene]-4-phenyl-1-thia-4-azaspiro[4.5]decan-3-one | 1246086-92-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: 2-[(4-chlorophenyl)methylidene]-4-phenyl-1-thia-4-azaspiro[4.5]decan-3-one
• CAS: 1246086-92-9
• 化学式: C₂₁H₂₀ClNOS
• 分子量: 369.915
• InChiKey: ZOIBFJBBWXKYQJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.12
• 重原子数：
  25.0
• 可旋转键数：
  2.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  20.31
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  2-[(4-chlorophenyl)methylidene]-4-phenyl-1-thia-4-azaspiro[4.5]decan-3-one 在 肼 作用下， 以 乙醇 、 水 为溶剂， 反应 4.0h， 以80%的产率得到3-(4-chlorophenyl)-6-phenylspiro[2,3-dihydro-1H-pyrazolo[3,4-d][1,3]thiazole-5,1'-cyclohexane]
  参考文献：
  名称：

  Facile Novel Synthesis and Reactions of Thiazolidin-4-one Derivatives for Antimicrobial Agents

  摘要：

  A facile and fast procedure for synthesis of 3-phenyl-cyclohexane(1'-2)thiazolidin-4-one (1), which underwent condensation with glucose and p-chlorobenzaldehyde to afford 2 and 3, respectively. Compound 3 was used as precursor for the preparation of some fused heterocyclic compounds 4-7. Compound 4 was alkylated using dichloroacetone and chloroacetic acid to afford 8 and 9, respectively. Also, it reacted with acrylonitrile and hydrazine hydrate to afford 10 and 11, respectively. Compound 9 was condensed with p-chlorobenzaldehyde and glucose to afford 12 and 13, respectively. Selected members of the synthesized compounds were screened for antimicrobial activity.

  DOI：

  10.1080/00397910903318674
• 作为产物：
  描述：

  4-phenyl-1-thia-4-azaspiro[4.5]decan-3-one 、 4-氯苯甲醛 在 sodium acetate 、 乙酸酐 、 溶剂黄146 作用下， 反应 3.0h， 以65%的产率得到2-[(4-chlorophenyl)methylidene]-4-phenyl-1-thia-4-azaspiro[4.5]decan-3-one
  参考文献：
  名称：

  Facile Novel Synthesis and Reactions of Thiazolidin-4-one Derivatives for Antimicrobial Agents

  摘要：

  A facile and fast procedure for synthesis of 3-phenyl-cyclohexane(1'-2)thiazolidin-4-one (1), which underwent condensation with glucose and p-chlorobenzaldehyde to afford 2 and 3, respectively. Compound 3 was used as precursor for the preparation of some fused heterocyclic compounds 4-7. Compound 4 was alkylated using dichloroacetone and chloroacetic acid to afford 8 and 9, respectively. Also, it reacted with acrylonitrile and hydrazine hydrate to afford 10 and 11, respectively. Compound 9 was condensed with p-chlorobenzaldehyde and glucose to afford 12 and 13, respectively. Selected members of the synthesized compounds were screened for antimicrobial activity.

  DOI：

  10.1080/00397910903318674