ethyl (2S)-2-[(3S,4S)-3-benzyl-2-(4-methoxybenzyl)-1-oxo-2-azaspiro[4.5]decan-4-yl]propanoate | 934980-33-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: ethyl (2S)-2-[(3S,4S)-3-benzyl-2-(4-methoxybenzyl)-1-oxo-2-azaspiro[4.5]decan-4-yl]propanoate
• 英文别名: ethyl (2S)-2-[(3S,4R)-3-benzyl-2-[(4-methoxyphenyl)methyl]-1-oxo-2-azaspiro[4.5]decan-4-yl]propanoate
• CAS: 934980-33-3
• 化学式: C₂₉H₃₇NO₄
• 分子量: 463.617
• InChiKey: CSZNNXHHJQHDQX-MZBJOSPHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  34
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl (2S)-2-[(3S,4S)-3-benzyl-2-(4-methoxybenzyl)-1-oxo-2-azaspiro[4.5]decan-4-yl]propanoate 在 锂硼氢 作用下， 以 乙醚 为溶剂， 反应 2.0h， 生成 (2S)-2-[(3S,4S)-3-benzyl-2-(4-methoxybenzyl)-1-oxo-2-azaspiro[4.5]decan-4-yl]propanol
  参考文献：
  名称：

  Dynamic Diastereoselectivity during Iron Carbonyl Mediated Spirocyclization Reactions

  摘要：

  Dynamic diastereoselectivity during Fe(CO)(3) promoted [6 + 2] ene spirocyclization of 35a and 35b, having a chiral center on the pendent side chain, was investigated and gave rise to products 28a and 28b instead of four possible isomers. From this reaction, two chiral centers are generated, with absolute stereochemistry determined by the double bond geometry and the chiral center already present. 28a/b and the diene product from demetallation of 28a are proposed as potential intermediates for total synthesis of 18-deoxycytochalasin H. Furthermore, a stepwise second cyclization and a tandem double cyclization mediated by the Fe(CO)(3) moiety was investigated.

  DOI：

  10.1021/jo0625608
• 作为产物：
  描述：

  ethyl (2S)-2-[(3S,4S)-3-benzyl-2-(4-methoxybenzyl)-1-oxo-2-azaspiro[4.5]deca-6,8-dien-4-yl]propanoate 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 反应 24.0h， 以84%的产率得到ethyl (2S)-2-[(3S,4S)-3-benzyl-2-(4-methoxybenzyl)-1-oxo-2-azaspiro[4.5]decan-4-yl]propanoate
  参考文献：
  名称：

  Dynamic Diastereoselectivity during Iron Carbonyl Mediated Spirocyclization Reactions

  摘要：

  Dynamic diastereoselectivity during Fe(CO)(3) promoted [6 + 2] ene spirocyclization of 35a and 35b, having a chiral center on the pendent side chain, was investigated and gave rise to products 28a and 28b instead of four possible isomers. From this reaction, two chiral centers are generated, with absolute stereochemistry determined by the double bond geometry and the chiral center already present. 28a/b and the diene product from demetallation of 28a are proposed as potential intermediates for total synthesis of 18-deoxycytochalasin H. Furthermore, a stepwise second cyclization and a tandem double cyclization mediated by the Fe(CO)(3) moiety was investigated.

  DOI：

  10.1021/jo0625608