1-(4-Hydroxyazepan-1-yl)ethanone | 1219828-20-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂环庚烷
• 英文名称: 1-(4-Hydroxyazepan-1-yl)ethanone
• CAS: 1219828-20-2
• 化学式: C₈H₁₅NO₂
• mdl: MFCD16653321
• 分子量: 157.21
• InChiKey: YHRVKYMONALYSB-UHFFFAOYSA-N

物化性质

• 沸点：
  313.6±35.0 °C(Predicted)
• 密度：
  1.095±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.875
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS<br/>[FR] COMPOSÉS ET LEUR UTILISATION POUR LE TRAITEMENT DE TROUBLES ASSOCIÉS AU RÉCEPTEUR H3 DE L'HISTAMINE
  申请人：TAKEDA PHARMACEUTICAL

  公开号：WO2013027001A1

  公开（公告）日：2013-02-28

  The present invention provides compounds of formula (1) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, m, n, p, q, Q1, Q2, Q3, Q4, Q5, Q6, X1, X2, X3, X4, A1 and L1, are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

  本发明提供了式（1）的化合物及其药学上可接受的盐，其中R1、R2、R3、R4、R5、R6、R7、R8、R9、R10、R11、R12、R13、R14、R15、R16、R17、R18、R19、R20、m、n、p、q、Q1、Q2、Q3、Q4、Q5、Q6、X1、X2、X3、X4、A1和L1如规范中所定义，其制备方法，含有它们的药物组合物以及它们在治疗中的用途。
• CYCLOALKYLOXY-AND HETEROCYCLOALKYLOXYPYRIDINE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR
  申请人：Letavic Michael A.

  公开号：US20090131415A1

  公开（公告）日：2009-05-21

  Certain cycloalkyloxy- and heterocycloalkyloxypyridine compounds are histamine H 3 receptor modulators useful in the treatment of histamine H 3 receptor-mediated diseases.

  某些环烷氧基和杂环烷氧基吡啶化合物是组织胺H3受体调节剂，可用于治疗组织胺H3受体介导的疾病。
• PROCESS FOR THE PREPARATION OF HISTAMINE H3 RECEPTOR MODULATORS
  申请人：Broggini Diego

  公开号：US20120029189A1

  公开（公告）日：2012-02-02

  The present invention is directed to novel processes for the preparation of histamine H3 receptor modulators, in the treatment of for example, cognitive disorders, sleep disorders and/or psychiatric disorders.

  本发明涉及一种新型的组织胺H3受体调节剂制备方法，用于治疗认知障碍、睡眠障碍和/或精神障碍。
• Process for the preparation of histamine H3 receptor modulators
  申请人：Janssen Pharmaceutica NV

  公开号：US10323002B2

  公开（公告）日：2019-06-18

  The present invention is directed to novel processes for the preparation of histamine H3 receptor modulators, in the treatment of for example, cognitive disorders, sleep disorders and/or psychiatric disorders.

  本发明涉及组胺 H3 受体调节剂的新型制备工艺，用于治疗认知障碍、睡眠障碍和/或精神障碍等疾病。
• CYCLOALKYLOXY-AND HET ROCYCLOALKY- LOXYPYRIDINE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR
  申请人：Janssen Pharmaceutica, N.V.

  公开号：EP2222664A1

  公开（公告）日：2010-09-01