n-hexadecylate de sodium | 24685-73-2

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 英文名称: n-hexadecylate de sodium
• 英文别名: Sodium;hexadecan-1-olate
• CAS: 24685-73-2
• 化学式: C₁₆H₃₃O*Na
• 分子量: 264.427
• InChiKey: ZRKFWLLSRVUDLJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.83
• 重原子数：
  18
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  n-hexadecylate de sodium 以 苯 为溶剂， 反应 49.0h， 生成
  参考文献：
  名称：

  Analyse par résonance magnétique nucléaire ¹³C de la stabilité relative des spirochromènes et des mérocyanines dérivant du méthoxy-3 nitro-5 salicylaldéhyde

  摘要：

  杂环亚铵盐通常与3-甲氧基-5-硝基水杨醛反应，生成螺环色酮或亚氰甙。只有后者在噻唑啉和苯并咪唑啉系列中得到。将烷环连接到亚氰甙中允许进行其¹³C nmr研究。将它们的光谱与杂环亚铵盐的光谱进行比较强调了噻唑啉和苯并咪唑啉系列中的超共轭效应。苯并噁唑啉系列似乎处于中间位置：螺环色酮和亚氰甙的热力学稳定性非常相似。可以近似确定亚氰甙中涉及的碳原子的化学位移的极限值。

  DOI：

  10.1139/v82-380
• 作为产物：
  描述：

  1-十六烷醇 生成 n-hexadecylate de sodium
  参考文献：
  名称：

  RAO, SAMALA JAGADISHWAR;BHALERAO, UDAY T.;TILAK, BAL DATTATREYA, INDIAN J. CHEM. B., 27,(1988) N 3, C. 277-278

  摘要：

  DOI：

文献信息

• Synthesis of surfactants based on pentaerythritol. II. Anionic gemini surfactants
  作者：Thomas Tran、Nusrat Jahan、D. Gerrard Marangoni、T. Bruce Grindley

  DOI：10.1139/cjc-2013-0256

  日期：2013.11

  Efficient syntheses of three series of anionic gemini surfactants based on pentaerythritol are described. A series of disulfates was prepared by the double displacement of the two cyclic sulfates in the S₄-symmetric compound pentaerythritol spirobicyclic sulfate (1) with linear alkoxides. A second series of disulfates was prepared by reaction of the dialkoxides of di-O-alkylpentaerythritols with ethylene sulfate. The di-O-alkylpentaerythritols can be prepared as previously reported by us or by the acid-catalyzed hydrolysis of the first series of disulfates. A series of disulfonates was prepared by reaction of the dialkoxides of di-O-alkylpentaerythritols with 1,3-propanesultone. This last set of reactions was complicated by the formation of oxetanes, which probably arose from initial reversible displacement on sulfur of the sultone alkoxide by the pentaerythritol alkoxide followed by a second intramolecular displacement of the resulting sulfonate. Changing the order of addition to keep the reaction medium from containing excess base as well as lowering the reaction temperature minimized the amounts of these byproducts. All three series had excellent surfactant properties.

  本文描述了基于季戊四醇的三种阴离子双季铵盐表面活性剂的有效合成方法。第一系列的双硫酸盐是通过季戊四醇螺环双环硫酸盐（1）中的两个环状硫酸盐与线性醇盐的双位移反应制备的。第二系列的双硫酸盐是通过二-O-烷基季戊四醇的二烷氧基与乙烯硫酸反应制备的。二-O-烷基季戊四醇可以按照我们之前报道的方法制备，或者通过第一系列双硫酸盐的酸催化水解来制备。第三系列的双磺酸盐是通过二-O-烷基季戊四醇的二烷氧基与1,3-丙烷磺内酯反应制备的。最后一组反应由于环状化合物的形成而变得复杂，这些环状化合物可能是由于磺内酯醇盐在硫上的可逆位移被季戊四醇醇盐取代，随后发生第二次分子内位移生成的磺酸盐。改变添加顺序以保持反应介质中不过量碱，以及降低反应温度，最小化了这些副产物的产生量。所有三个系列都具有极好的表面活性剂性能。

• Studies on antitumor agents. V. Syntheses and antitumor activities of 5-fluorouracil derivatives.
  作者：JUNICHI YAMASHITA、ICHIRO YAMAWAKI、SHUICHI UEDA、MITSUGI YASUMOTO、NORIO UNEMI、SADAO HASHIMOTO

  DOI：10.1248/cpb.30.4258

  日期：——

  Six types of 5-fluorouracil (5-FU) derivatives were synthesized ; namely, 2, 4-di-O-substituted, 2-O-substituted, 4-O-substituted, 1, 3-disubstituted, 1-substituted and 3-substituted compounds. After oral administration of these compounds to rats, the blood levels of 5-FU were determined. Among O-substituted derivatives, a 4-O-substituted derivative was most easily activated to 5-FU and 2-O-substituted derivatives were next most easily activated. Among N-substituted derivatives, acyl and sulfonyl derivatives showed the highest 5-FU releasing abilities and 1-alkoxymethyl substituted derivatives showed low ability. N-Alkyl substituted derivatives were not activated to 5-FU. Several compounds which gave higher blood levels of 5-FU than that obtained with 1-(tetrahydro-2-furyl)-5-fluorouracil (Thf-FU), as well as same related compounds, were selected and their antitumor activities were examined. The 2-O-substituted derivatives, 2-butoxy-5-fluoro-4 (1H)-pyrimidone (11) and 2-benzyloxy-5-fluoro-4 (1H)-pyrimidone (19), were as effective as Thf-FU. The activities of 2, 4-di-O-substituted derivatives, 2, 4-dibutoxy-5-fluoropyrimidine (1) and 2, 4-dibenzyloxy-5-fluoropyrimidine (6), against Ehrlich carcinoma and against sarcoma 180, respectively, were the same as those of Thf-FU. The 1-substituted derivatives, 1-ethoxymethyl-5-fluorouracil (49) and 1-(1-ethoxy-1-phenylmethyl)-5-fluorouracil (50), were found to be as effective as Thf-FU.

  合成了六类氟尿嘧啶（5-FU）衍生物，即2,4-二-O-取代、2-O-取代、4-O-取代、1,3-二取代、1-取代和3-取代的化合物。在大鼠口服这些化合物后，测定了5-FU的血药浓度。在O-取代衍生物中，4-O-取代衍生物最容易被激活为5-FU，其次是2-O-取代衍生物。在N-取代衍生物中，酰基和磺酰基衍生物显示出最高的5-FU释放能力，1-烷氧甲基取代衍生物的释放能力较低。N-烷基取代衍生物未被激活为5-FU。选择了几种在血中5-FU水平高于1-(四氢-2-呋喃基)-5-氟尿嘧啶（Thf-FU）的化合物，以及一些相关化合物，并对其抗肿瘤活性进行了检测。2-O-取代衍生物，2-丁氧基-5-氟-4(1H)-嘧啶酮（11）和2-苄氧基-5-氟-4(1H)-嘧啶酮（19），与Thf-FU一样有效。2,4-二-O-取代衍生物，2,4-二丁氧基-5-氟嘧啶（1）和2,4-二苄氧基-5-氟嘧啶（6），对艾氏癌和肉瘤180的活性与Thf-FU相同。1-取代衍生物，1-乙氧甲基-5-氟尿嘧啶（49）和1-(1-乙氧基-1-苯甲基)-5-氟尿嘧啶（50），发现与Thf-FU一样有效。
• New synthesis of 2-thio-paf and related compounds as substrates of PAF acetylhydrolase and phospholipase A2.
  作者：Masakazu MURATA、Shigekazu IKOMA、Kazuo ACHIWA

  DOI：10.1248/cpb.39.1335

  日期：——

  2-Thio-PAF and related compounds (1a-c) as substrates of PAF acetylhydrolase and phospholipase A2 were synthesized stereoselectively from optically active 2-O-benzylglycerol monoacetate.

  2-硫基-PAF及相关化合物（1a-c）作为PAF醋酸酯水解酶和磷脂酶A2的底物，采用立体选择性合成自光学活性的2-O-苄基甘油单乙酸酯。
• Synthesis of 2-Thio-platlet Activating Factor and Related Compounds.
  作者：Masakazu MURATA、Hiroshi UCHIDA、Kazuo ACHIWA

  DOI：10.1248/cpb.40.2849

  日期：——

  2-Thio-platlet-activating factor and related compounds as substrates of platlet activating factor acetylhydrolase and phospholipase A2 were synthesized from optically active 2-O-benzylglycerol monoacetate.

  以具有光学活性的 2-O-苄基甘油单乙酸酯为原料，合成了作为血小板活化因子乙酰水解酶和磷脂酶 A2 底物的 2-硫代血小板活化因子和相关化合物。
• PUGACH E. S.; AKODEDZHI EH.; MOKRIVSKIJ T. M., BECTH. LVOV. POLITEXN. IN-TA, 1980, HO 139, 137-139
  作者：PUGACH E. S.、 AKODEDZHI EH.、 MOKRIVSKIJ T. M.

  DOI：——

  日期：——