6-bromo-3-[4-((1S,3R,5R)-8-methyl-8-azabicyclo[3.2.1]oct-3-yloxy)phenyl]-3H-thieno[3,2-d]pyrimidin-4-one | 947176-27-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并嘧啶酮衍生物
• 英文名称: 6-bromo-3-[4-((1S,3R,5R)-8-methyl-8-azabicyclo[3.2.1]oct-3-yloxy)phenyl]-3H-thieno[3,2-d]pyrimidin-4-one
• CAS: 947176-27-4
• 化学式: C₂₀H₂₀BrN₃O₂S
• 分子量: 446.368
• InChiKey: QDQAZKVJHIPFNW-FOLVSLTJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.21
• 重原子数：
  27.0
• 可旋转键数：
  3.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  47.36
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  2-吡咯烷酮 、 6-bromo-3-[4-((1S,3R,5R)-8-methyl-8-azabicyclo[3.2.1]oct-3-yloxy)phenyl]-3H-thieno[3,2-d]pyrimidin-4-one 在 tris(dibenzylideneacetone)dipalladium(0) chloroform complex 、 4,5-双二苯基膦-9,9-二甲基氧杂蒽 caesium carbonate 作用下， 以 1,4-二氧六环 为溶剂， 反应 22.0h， 生成 3-[4-((1R,3R,5S)-8-methyl-8-azabicyclo[3.2.1]oct-3-yloxy)phenyl]-6-(2-oxopyrrolidin-1-yl)-3H-thieno[3,2-d]pyrimidin-4-one
  参考文献：
  名称：

  WO2007/93365

  摘要：

  公开号：

文献信息

• NOVEL AMINO ALCOHOL-SUBSTITUTED ARYLTHIENOPYRIMIDINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
  申请人：SCHWINK Lothar

  公开号：US20090076002A1

  公开（公告）日：2009-03-19

  The invention relates to amino alcohol-substituted arylthienopyrimidinones and their derivatives, and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least one amino alcohol-substituted arylthienopyrimidinone of the invention or its derivative, and the use of the amino alcohol-substituted arylthienopyrimidinones of the invention and their derivatives as MCH antagonists.

  本发明涉及氨基醇取代的芳基噻唑嘧啶酮及其衍生物、其生理上可耐受的盐和生理功能衍生物、其制备方法、包含本发明中至少一种氨基醇取代的芳基噻唑嘧啶酮或其衍生物的药物以及将本发明中的氨基醇取代的芳基噻唑嘧啶酮及其衍生物用作MCH拮抗剂的用途。
• US8853208B2
  申请人：——

  公开号：US8853208B2

  公开（公告）日：2014-10-07
• [EN] NOVEL AMINO ALCOHOL-SUBSTITUTED ARYLTHIENOPYRIMIDINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS<br/>[FR] NOUVELLES ARYLTHIÉNOPYRIMIDINONES À SUBSTITUTION AMINOALCOOL, LEUR PROCÉDÉ DE PRÉPARATION ET LEUR UTILISATION COMME MÉDICAMENTS
  申请人：SANOFI AVENTIS

  公开号：WO2007093365A2

  公开（公告）日：2007-08-23

  [EN] The invention relates to amino alcohol-substituted arylthienopyrimidinones and their derivatives, and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least one amino alcohol-substituted arylthienopyrimidinone of the invention or its derivative, and the use of the amino alcohol- substituted arylthienopyrimidinones of the invention and their derivatives as MCH antagonists.
  [FR] L'invention concerne des arylthiénopyrimidinones à substitution aminoalcool et leurs dérivés ainsi que leurs sels physiologiquement tolérés et leurs dérivés physiologiquement fonctionnels, leur préparation, des médicaments comprenant au moins une arylthiénopyrimidinone à substitution aminoalcool de l'invention ou un de ses dérivés, ainsi que l'utilisation des arylthiénopyrimidinones à substitution aminoalcool de l'invention et de leurs dérivés comme antagonistes de l'hormone de mélanoconcentration (MCH).