2-chloro-4,6-bis(3,4-dimethyl phenyl)-1,3,5-triazine | 423177-97-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 2-chloro-4,6-bis(3,4-dimethyl phenyl)-1,3,5-triazine
• 英文别名: 2-Chloro-4,6-bis(3,4-dimethylphenyl)-1,3,5-triazine
• CAS: 423177-97-3
• 化学式: C₁₉H₁₈ClN₃
• 分子量: 323.825
• InChiKey: UCHVSIZXSRLSOK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  间苯二酚 、 2-chloro-4,6-bis(3,4-dimethyl phenyl)-1,3,5-triazine 反应 2.0h， 以to form 83% of 2-(2,4-dihydroxyphenyl)-4,6-bis(3,4-dimethylphenyl)-1,3,5-triazine and 6% of its isomer的产率得到2-(2.4-dihydroxyphenyl)-4,6-bis(3,4-dimethylphenyl)-1,3,5-triazine
  参考文献：
  名称：

  Process for making triazine UV absorbers using Lewis acids and reaction promoters

  摘要：

  经过广泛的研究后惊奇地发现，可以在至少一种路易斯酸和至少一种反应促进剂的存在下，通过氰尿酸卤化物与芳香族化合物反应，在温和条件和高产率下实现无前例的选择性制备2-卤代-4,6-双芳基-1,3,5-三嗪。这种反应也是无前例的通用的，因为多种芳香族化合物可以用来产生各种2-卤代-4,6-双芳基-1,3,5-三嗪选择。新颖的方法包括在特定反应条件下将反应促进剂与至少一种路易斯酸结合使用，以促进从氰尿酸卤化物形成2-卤代-4,6-双芳基-1,3,5-三嗪化合物的形成。最好是将路易斯酸和反应促进剂组合形成一个复合物。2-卤代-4,6-双芳基-1,3,5-三嗪是制造2-(2-氧基芳基)-4,6-双芳基-1,3,5-三嗪类紫外线吸收剂的关键中间体。

  公开号：

  US06486316B1

文献信息

• Process for making triazine UV absorbers using lewis acids and reaction promoters
  申请人：CYTEC Technologies Corp.

  公开号：US20010020094A1

  公开（公告）日：2001-09-06

  It has been now surprisingly discovered after extensive research that 2-halo-4,6-bisaryl-1,3,5-triazine can be prepared with unprecedented selectivity, efficiency, mild conditions, and in high yield by the reaction of cyanuric halide with aromatics in the presence of at least one Lewis acid and at least one reaction promoter. This reaction is also unprecedently general as a variety of aromatics can be used to produce a wide selection of 2-halo-4,6-bisaryl-1,3,5-triazines. The novel approach includes the use of the reaction promoters in combination with at least one Lewis acid under certain reaction conditions to promote the formation of 2-halo-4,6-bisaryl-1,3,5-triazine compounds from cyanuric halide. Preferably, the Lewis acids and reaction promoters are combined to form a complex. 2-Halo-4,6-bisaryl-1,3,5-triazines are key intermediates for making 2-(2-oxyaryl)-4,6-bisaryl-1,3,5-triazine class of UV absorbers.

  经过广泛的研究，令人惊讶地发现，通过氰尿酸卤化物与芳香族化合物在至少一种路易斯酸和至少一种反应促进剂的存在下反应，可以以前所未有的选择性、效率、温和条件和高产率制备2-卤代-4,6-双芳基-1,3,5-三嗪。该反应具有前所未有的广泛性，因为可以使用各种芳香族化合物来生产各种2-卤代-4,6-双芳基-1,3,5-三嗪。新的方法包括在特定反应条件下，将反应促进剂与至少一种路易斯酸结合使用，促进从氰尿酸卤化物中形成2-卤代-4,6-双芳基-1,3,5-三嗪化合物。最好将路易斯酸和反应促进剂组合形成复合物。2-卤代-4,6-双芳基-1,3,5-三嗪是制备2-(2-氧基芳基)-4,6-双芳基-1,3,5-三嗪类紫外线吸收剂的关键中间体。
• Process for Making Trisaryl Triazine UV Absorbers Using Lewis Acids and Reaction Promoters
  申请人：Gupta B. Ram

  公开号：US20070015920A1

  公开（公告）日：2007-01-18

  It has been now surprisingly discovered after extensive research that 2-halo-4,6-bisaryl-1,3,5-triazine can be prepared with unprecedented selectivity, efficiency, mild conditions, and in high yield by the reaction of cyanuric halide with aromatics in the presence of at least one Lewis acid and at least one reaction promoter. This reaction is also unprecedently general as a variety of aromatics can be used to produce a wide selection of 2-halo-4,6-bisaryl-1,3,5-triazines. The novel approach includes the use of the reaction promoters in combination with at least one Lewis acid under certain reaction conditions to promote the formation of 2-halo-4,6-bisaryl-1,3,5-triazine compounds from cyanuric halide. Preferably, the Lewis acids and reaction promoter's are combined to form a complex 2-Halo-4,6-bisaryl-1,3,5-triazines are key intermediates for making 2-(2-oxyaryl)-4,6-bisaryl-1,3,5-triazine class of UV absorbers.

  经过广泛的研究，惊奇地发现可以通过氰尿酸卤化物与芳香族化合物在至少一种路易斯酸和至少一种反应促进剂的存在下反应，在温和的条件下高效、高产地选择性地制备2-卤代-4,6-双芳基-1,3,5-三嗪，这种反应也是前所未有的普遍的，因为各种芳香族化合物都可以用来生产各种2-卤代-4,6-双芳基-1,3,5-三嗪。新的方法包括在特定的反应条件下，使用反应促进剂与至少一种路易斯酸结合，促进从氰尿酸卤化物中形成2-卤代-4,6-双芳基-1,3,5-三嗪化合物。最好是将路易斯酸和反应促进剂组合形成复合物。2-卤代-4,6-双芳基-1,3,5-三嗪是制造2-(2-氧基芳基)-4,6-双芳基-1,3,5-三嗪类紫外线吸收剂的关键中间体。
• Process for making trisaryl triazine UV absorbers using Lewis acids and reaction promoters
  申请人：Cytec Technology Corp.

  公开号：US07485723B2

  公开（公告）日：2009-02-03

  It has been now surprisingly discovered after extensive research that 2-halo-4,6-bisaryl-1,3,5-triazine can be prepared with unprecedented selectivity, efficiency, mild conditions, and in high yield by the reaction of cyanuric halide with aromatics in the presence of at least one Lewis acid and at least one reaction promoter. This reaction is also unprecedently general as a variety of aromatics can be used to produce a wide selection of 2-halo-4,6-bisaryl-1,3,5-triazines. The novel approach includes the use of the reaction promoters in combination with at least one Lewis acid under certain reaction conditions to promote the formation of 2-halo-4,6-bisaryl-1,3,5-triazine compounds from cyanuric halide. Preferably, the Lewis acids and reaction promoters are combined to form a complex 2-Halo-4,6-bisaryl-1,3,5-triazines are key intermediates for making 2-(2-oxyaryl)-4,6-bisaryl-1,3,5-triazine class of UV absorbers.

  经过广泛的研究，现已惊人地发现，通过氰尿酸卤化物与芳香族化合物在至少一种路易斯酸和至少一种反应促进剂的存在下反应，可以以前所未有的选择性、效率、温和条件和高收率制备2-卤代-4,6-双芳基-1,3,5-三嗪。这种反应也是前所未有的通用，因为可以使用各种芳香族化合物来产生各种2-卤代-4,6-双芳基-1,3,5-三嗪的选择。新的方法包括在特定的反应条件下，将反应促进剂与至少一种路易斯酸结合使用，促进从氰尿酸卤化物形成2-卤代-4,6-双芳基-1,3,5-三嗪化合物。最好是将路易斯酸和反应促进剂组合形成复合物。2-卤代-4,6-双芳基-1,3,5-三嗪是制造2-(2-氧基芳基)-4,6-双芳基-1,3,5-三嗪紫外线吸收剂类的关键中间体。
• PROCESS FOR PREPARING TRIAZINES USING A COMBINATION OF LEWIS ACIDS WITH REACTION PROMOTERS
  申请人：CYTEC TECHNOLOGY CORP.

  公开号：EP1131305B1

  公开（公告）日：2006-11-02
• NON-YELLOWING ORTHO-DIALKYL ARYL SUBSTITUTED TRIAZINE ULTRAVIOLET LIGHT ABSORBERS
  申请人：CYTEC TECHNOLOGY CORP.

  公开号：EP1330445A1

  公开（公告）日：2003-07-30