Phenyl 4-guanidinobenzoate | 35695-21-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: Phenyl 4-guanidinobenzoate
• 英文别名: 4-Guanidinobenzoesaeurephenylester；Phenyl-4-guanidinobenzoat；phenyl 4-(diaminomethylideneamino)benzoate
• CAS: 35695-21-7
• 化学式: C₁₄H₁₃N₃O₂
• 分子量: 255.276
• InChiKey: PXPIXLVXGYQMFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  90.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  p-guanidinobenzoic acid chloride 生成 Phenyl 4-guanidinobenzoate
  参考文献：
  名称：

  IMAKI, KATSUXIRO;ARAI, JOSINOBU;ONO, XIROYUKI

  摘要：

  DOI：

文献信息

• BENZOATE COMPOUND
  申请人：SCOHIA PHARMA, INC.

  公开号：US20210403420A1

  公开（公告）日：2021-12-30

  The present invention provides a benzoic acid ester compound that has an enteropeptidase inhibitory effect, and use of the compound as a medicament for the treatment or prevention of obesity, diabetes mellitus, or the like. A compound represented by the formula (I) or a salt thereof has an enteropeptidase inhibitory effect and is useful as a medicament for the treatment or prevention of obesity, diabetes mellitus, or the like: [in the formula, each symbol is as defined in the specification].

  本发明提供了一种苯甲酸酯化合物，具有肠肽酶抑制作用，并将该化合物用作治疗或预防肥胖、糖尿病等疾病的药物。由式（I）表示的化合物或其盐具有肠肽酶抑制作用，并可用作治疗或预防肥胖、糖尿病等疾病的药物。【在公式中，每个符号如规范中定义】。
• HETEROCYCLIC COMPOUND
  申请人：Takeda Pharmaceutical Company Limited

  公开号：US20150225354A1

  公开（公告）日：2015-08-13

  A fused heterocyclic compound having an enteropeptidase inhibitory action and use of the compound as a medicament for treatment or prophylaxis of obesity, diabetes mellitus, etc., are provided. Specifically, a compound represented by the following formula (I): wherein each symbol is as defined herein, or a salt thereof and use of the compound as a medicament for treatment or prophylaxis of obesity, diabetes mellitus, etc., are provided.

  提供一种具有肠肽酶抑制作用的融合杂环化合物以及将该化合物用作治疗或预防肥胖、糖尿病等疾病的药物。具体来说，提供一种由以下公式（I）表示的化合物：其中每个符号均如本文所定义，或其盐，并提供将该化合物用作治疗或预防肥胖、糖尿病等疾病的药物。
• GUANIDINOBENZOIC ACID ESTER COMPOUND
  申请人：ASTELLA PHARMA INC.

  公开号：US20160031847A1

  公开（公告）日：2016-02-04

  [Problem]To provide a compound which is useful as an agent for preventing and/or treating kidney diseases. [Means for Solution]The present inventors have studied compounds having a trypsin inhibitory activity, and have confirmed that a guanidinobenzoic acid ester compound has a trypsin inhibitory activity, thereby completing the present invention. The guanidinobenzoic acid ester compound of the present invention can be used as an agent for preventing and/or treating kidney diseases (for example, chronic kidney disease, acute glomerulonephritis, acute kidney injury, and the like) as an agent which will substitute low-protein diet therapy, and/or as an agent for preventing and/or treating trypsin-related diseases (for example, chronic pancreatitis, gastroesophageal reflux disease, hepatic encephalopathy, influenza, and the like).

  提供一种可用作预防和/或治疗肾脏疾病的化合物。现发明人研究了具有胰蛋白酶抑制活性的化合物，并确认一种鸟氨酸苯甲酸酯化合物具有胰蛋白酶抑制活性，从而完成了本发明。本发明的鸟氨酸苯甲酸酯化合物可用作预防和/或治疗肾脏疾病的药剂（例如，慢性肾病、急性肾小球肾炎、急性肾损伤等），作为替代低蛋白饮食疗法的药剂，和/或作为预防和/或治疗与胰蛋白酶相关疾病的药剂（例如，慢性胰腺炎、胃食管反流病、肝性脑病、流感等）。
• GUANIDINOBENZOIC ACID COMPOUND
  申请人：Fujiyasu Jiro

  公开号：US20140378459A1

  公开（公告）日：2014-12-25

  [Problem] Provided is a compound which is useful as an agent for preventing and/or treating renal diseases. [Means for Solution] The present inventors have conducted extensive studies on compounds having a trypsin inhibitory action, and as a result, they have found that a guanidinobenzoic acid compound has a trypsin inhibitory action, thereby completing the present invention. The guanidinobenzoic acid compound of the present invention can be used as an agent for preventing and/or treating renal disease as an agent which will substitute low-protein diet therapy, and an agent for preventing and/or treating trypsin-related diseases, for example, pancreatitis, gastroesophageal reflux disease, hepatic encephalopathy, influenza, and the like.

  [问题] 提供了一种化合物，可用作预防和/或治疗肾脏疾病的药剂。[解决方案] 现有发明人对具有胰蛋白酶抑制作用的化合物进行了广泛的研究，结果发现一种鸟氨酸苯甲酸化合物具有胰蛋白酶抑制作用，从而完成了本发明。本发明的鸟氨酸苯甲酸化合物可用作代替低蛋白饮食疗法的药剂，以及预防和/或治疗胰蛋白酶相关疾病（例如，胰腺炎，胃食管反流病，肝性脑病，流感等）的药剂。
• PHENYL 4-GUANIDINOBENZOATE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND PROTEASE INHIBITOR CONTAINING THE SAME
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：EP0486702A1

  公开（公告）日：1992-05-27

  A phenyl 4-guanidinobenzoate derivative of general formula (I) and a pharmacologically acceptable acid addition salt thereof, each having an excellent protease inhibitor activity, wherein R¹ represents hydrogen or halogen; R² represents trifluoromethoxy, OCOR³, C(=NOR⁴)R⁵ or styrenesulfonyl; R³ represents (un)substituted C₃ to C₇ cycloalkyl; R⁴ represents hydrogen, C₁ to C₄ alkyl, C₁ to C₄ alkenyl or CH₂COOR⁶; R⁵ represents hydrogen or C₁ to C₄ alkyl; and R⁶ represents hydrogen or C₁ to C₄ alkyl.

  通式(I)的 4-胍基苯甲酸苯酯衍生物及其药理学上可接受的酸加成盐，各自具有优异的蛋白酶抑制剂活性，其中 R¹ 代表氢或卤素；R² 代表三氟甲氧基、OCOR³、C(=NOR⁴)R⁵ 或苯乙烯磺酰基；R³ 代表（未）取代的 C₃ 至 C₇ 环烷基；R⁴ 代表氢、C₁ 至 C₄ 烷基、C₁ 至 C₄ 烯基或 CH₂COOR⁶；R⁵ 代表氢或 C₁ 至 C₄ 烷基；以及 R⁶ 代表氢或 C₁ 至 C₄ 烷基。