tert-butoxycarbonylmethoxyimino-(2-tritylamino-thiazol-4-yl)-acetic acid | 104788-85-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: tert-butoxycarbonylmethoxyimino-(2-tritylamino-thiazol-4-yl)-acetic acid
• 英文别名: 2-[2-[(2-Methylpropan-2-yl)oxy]-2-oxoethoxy]imino-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetic acid
• CAS: 104788-85-4
• 化学式: C₃₀H₂₉N₃O₅S
• 分子量: 543.643
• InChiKey: RCTFWTDUBOCUDX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  39
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  138
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• [EN] OXAMAZIN ANTIBIOTICS<br/>[FR] ANTIBIOTIQUES À BASE D'OXAMAZINE
  申请人：REMPEX PHARMACEUTICALS INC

  公开号：WO2014164526A1

  公开（公告）日：2014-10-09

  Disclosed herein are oxamazin monobactam compounds and their use as antibiotics resistant to degradation by β-lactamases. Also disclosed are pharmaceutical compositions containing the compounds and methods of synthesis.

  本文披露了氧氨噁唑单环内酰胺化合物及其作为抗β-内酰胺酶降解的抗生素的用途。同时还披露了含有这些化合物的药物组合物和合成方法。
• 1-Oxadethiacephalosporin compound and antibacterial agent containing the same
  申请人：MEIJI SEIKA KAISHA LTD.

  公开号：EP0098615A1

  公开（公告）日：1984-01-18

  New 1-Oxadethiacephalosporins of the general formula: wherein R1 represents an alkyl group of 1 to 4 carbon atoms and R2 is a group of the formula: in which R3 is a hydrogen atom or carboxyl group, or a group of the formula: in which R4 is a hydrogen atom or amino group, and R5 represents an alkyl group of 1 to 4 carbon atoms or a group of the formula: where R6 and R7 may be the same or different and each is a hydrogen atom or an alkyl group of 1 to 4 carbon atoms, or a non-toxic salt or non-toxic ester of those compounds. Antibacterial compositions containing the same are also disclosed.

  通式为新的 1-氧二硫代头孢菌素： 其中 R1 代表 1 至 4 个碳原子的烷基，R2 是式中的一个基团： 其中 R3 是氢原子或羧基，或者是式中的一个基团： 其中 R4 是氢原子或氨基，R5 代表 1 至 4 个碳原子的烷基或式如下的基团 其中 R6 和 R7 可以相同或不同，且各自为氢原子或 1 至 4 个碳原子的烷基，或这些化合物的无毒盐或无毒酯。还公开了含有这些化合物的抗菌组合物。
• Novel cephalosporin compound and process for preparing the same
  申请人：Tanabe Seiyaku Co., Ltd.

  公开号：EP0081971A2

  公开（公告）日：1983-06-22

  A cephalosporin compound of the formula: wherein R1 is a hydrogen atom, a lower alkyl group, a carboxy-(lower)alkyl group, a hydroxy(lower)alkyl group, a carbamoyl-(lower)alkyl group, an N-(lower)-alkyl-carbamoyl(lower)alkyl group, a cycloalkyl group, a carboxycycloalkyl group, or a tetrazolylmethyl group, R2 is a hydrogen atom, a lower alkyl group, a formyl group or a lower alkanol group, R3 is a hydrogen atom, or R2 and R3 are combined together to form an aralkylidene group, or a pharmaceutically acceptable salt thereof which is useful as an antimicrobial agent, and process for their preparation.

  式中的头孢菌素化合物： 其中 R1 是氢原子、低级烷基、羧基（低级）烷基、羟基（低级）烷基、氨基甲酰基（低级）烷基、N-（低级）烷基-氨基甲酰基（低级）烷基、环烷基、羧基环烷基或四唑甲基；R2 是氢原子、低级烷基、甲酰基或低级烷醇基；R3 是氢原子，或 R2 和 R3 结合在一起形成芳基、R3是氢原子，或 R2 和 R3 结合在一起形成亚芳烷基，或其药学上可接受的盐，可用作抗菌剂，及其制备方法。
• Cephem compounds and the production thereof
  申请人：MEIJI SEIKA KAISHA LTD.

  公开号：EP0186586A2

  公开（公告）日：1986-07-02

  A class of new cephem compounds is now provided, which is useful as antibacterial agent and is represented by the general formula (I) wherein R' is methyl group or carboxymethyl group and R2 is carboxyl group or a protected carboxyl group, and a pharmaceutically acceptable salt or ester thereof.

  现提供一类可用作抗菌剂的新型头孢菌素化合物，由通式（I）表示，其中 R' 为甲基或羧甲基，R2 为羧基或受保护的羧基，以及其药用盐或酯。
• Novel cephem compound as an antimicrobial agent and its preparation
  申请人：MEJI SEIKA K.K.

  公开号：EP0357089A2

  公开（公告）日：1990-03-07

  A novel cephem compound which has antimicrobial activity is disclosed. The cephem compound is represented by the formula: wherein R1 represents a hydrogen atom or a carboxyl group; R2 and R3, which may be the same or different, each represent a hydrogen atom or a lower alkyl group of 1-3 carbon atoms; and R4 and R5, which may be the same or different, each represent a hydrogen atom or an acyl group; and pharmaceutically acceptable salts thereof.

  本发明公开了一种具有抗菌活性的新型头孢菌素化合物。这种 cephem 化合物由式表示： 其中 R1 代表氢原子或羧基；R2 和 R3（可以相同或不同）各自代表氢原子或 1-3 个碳原子的低级烷基；以及 R4 和 R5（可以相同或不同）各自代表氢原子或酰基；及其药学上可接受的盐类。