| 1101771-26-9

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 托烷生物碱
• CAS: 1101771-26-9
• 化学式: C₂₆H₂₃Cl₂N₃
• 分子量: 448.395
• InChiKey: BIFXVUAQGOVCDK-ZJZZYZHZSA-N

反应信息

• 作为反应物：
  描述：

  在 硫酸 作用下， 生成
  参考文献：
  名称：

  Identification of 3-substituted N-benzhydryl-nortropane analogs as nociceptin receptor ligands for the management of cough and anxiety

  摘要：

  A series of nortropane analogs based on previously reported compound 1 have been synthesized and shown to bind to the nociceptin receptor with high affinity. The synthesis and structure-activity relationships around the C-3 nortropane substitution are described. From the SAR study and hPXR screening effort, compound 15 was identified to possess potent oral antitussive and anxiolytic-like activities in the guinea pig models. (c) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.03.057
• 作为产物：
  描述：

  8-[Bis(2-chlorophenyl)methyl]-8-azabicyclo[3.2.1]octane-3-carbonitrile 、 alkaline earth salt of/the/ methylsulfuric acid 在 sodium hexamethyldisilazane 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  Identification of 3-substituted N-benzhydryl-nortropane analogs as nociceptin receptor ligands for the management of cough and anxiety

  摘要：

  A series of nortropane analogs based on previously reported compound 1 have been synthesized and shown to bind to the nociceptin receptor with high affinity. The synthesis and structure-activity relationships around the C-3 nortropane substitution are described. From the SAR study and hPXR screening effort, compound 15 was identified to possess potent oral antitussive and anxiolytic-like activities in the guinea pig models. (c) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.03.057

文献信息

• Structure–activity relationships of 3-substituted N-benzhydryl-nortropane analogs as nociceptin receptor ligands for the treatment of cough
  作者：Shu-Wei Yang、Ginny Ho、Deen Tulshian、William J. Greenlee、Xiomara Fernandez、Robbie L. McLeod、Stephen Eckel、John Anthes

  DOI：10.1016/j.bmcl.2008.10.088

  日期：2008.12

  A series of 3-axial-aminomethyl-N-benzhydryl-nortropane analogs have been synthesized and identified to bind to the nociceptin receptor with high affinity. Many of these analogs showed high binding selectivity over classic opioid receptors such as l receptor. The synthesis and structure-activity relationships around the C-3 nortropane substitution are described. Selected compounds with potent oral antitussive activity in the guinea pig model are disclosed. (C) 2008 Elsevier Ltd. All rights reserved.