phenyl 2,3,4-tri-O-(4-methoxyphenylmethyl)-6-O-triphenylmethyl-α-D-galactopyranosyl-(1->4)-2,3-di-O-(4-methoxyphenylmethyl)-1-thio-β-D-galactopyranoside | 1225450-83-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: phenyl 2,3,4-tri-O-(4-methoxyphenylmethyl)-6-O-triphenylmethyl-α-D-galactopyranosyl-(1->4)-2,3-di-O-(4-methoxyphenylmethyl)-1-thio-β-D-galactopyranoside
• CAS: 1225450-83-8
• 化学式: C₇₇H₈₀O₁₅S
• 分子量: 1277.54
• InChiKey: XMSDESUSEUWHQZ-HEELVHKHSA-N

反应信息

• 作为反应物：
  描述：

  phenyl 2,3,4-tri-O-(4-methoxyphenylmethyl)-6-O-triphenylmethyl-α-D-galactopyranosyl-(1->4)-2,3-di-O-(4-methoxyphenylmethyl)-1-thio-β-D-galactopyranoside 、 三苯基氯甲烷 在 吡啶 作用下， 反应 1.5h， 以98%的产率得到phenyl 2,3,4-tri-O-(4-methoxyphenylmethyl)-6-O-triphenylmethyl-α-D-galactopyranosyl-(1->4)-2,3-di-O-(4-methoxyphenylmethyl)-1-thio-6-O-triphenylmethyl-β-D-galactopyranoside
  参考文献：
  名称：

  Synthesis of a trigalacturonic acid analogue mimicking the expected transition state in the glycosidases

  摘要：

  A trigalacturonic acid analogue carrying a cyclohexene framework in place of the central pyranose ring was synthesized as a molecular probe for the mechanistic investigation of endo-polygalacturonase 1 (endo-PG 1). Preliminary enzymatic studies revealed that this analogue inhibited endo-PG 1 activity by about 30% at 0.3 mM concentration. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2009.12.024
• 作为产物：
  描述：

  phenyl 2,3,4-tri-O-(4-methoxyphenylmethyl)-6-O-triphenylmethyl-D-galactopyranosyl-(1->4)-6-O-benzoyl-2,3-di-O-(4-methoxyphenylmethyl)-1-thio-β-D-galactopyranoside 在 水 、 sodium hydroxide 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 5.0h， 以74%的产率得到phenyl 2,3,4-tri-O-(4-methoxyphenylmethyl)-6-O-triphenylmethyl-α-D-galactopyranosyl-(1->4)-2,3-di-O-(4-methoxyphenylmethyl)-1-thio-β-D-galactopyranoside
  参考文献：
  名称：

  Synthesis of a trigalacturonic acid analogue mimicking the expected transition state in the glycosidases

  摘要：

  A trigalacturonic acid analogue carrying a cyclohexene framework in place of the central pyranose ring was synthesized as a molecular probe for the mechanistic investigation of endo-polygalacturonase 1 (endo-PG 1). Preliminary enzymatic studies revealed that this analogue inhibited endo-PG 1 activity by about 30% at 0.3 mM concentration. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2009.12.024