ethyl dipropylcarbamodithioate | 27657-64-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 二硫代氨基甲酸及其衍生物
• 英文名称: ethyl dipropylcarbamodithioate
• 英文别名: dipropyl-dithiocarbamic acid ethyl ester；Dipropyl-dithiocarbamidsaeure-aethylester；N.N-Dipropyl-dithiourethan；ethyl-N,N-di-n-propyl-dithiocarbamate；ethyl N,N-dipropylcarbamodithioate
• CAS: 27657-64-3
• 化学式: C₉H₁₉NS₂
• 分子量: 205.389
• InChiKey: MTAQUGWFFULFKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  60.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  ethyl chlorodithioformate 、 二正丙胺 在 乙醚 作用下， 生成 ethyl dipropylcarbamodithioate
  参考文献：
  名称：

  v.Braun, Chemische Berichte, 1902, vol. 35, p. 3378

  摘要：

  DOI：

文献信息

• Sulfurized aqueous machining fluid composition
  申请人：CINCINNATI MILACRON INC.

  公开号：EP0656415A1

  公开（公告）日：1995-06-07

  Aqueous machining fluid compositions, especially aqueous metalworking fluid compositions, are provided that exhibit improved reduction of friction and forces in the mechanical shaping and working of metallic and solid non-metallic workpieces. These compositions comprise a) water, b) a sulfurized organic material selected from the group consisting of sulfurized unsaturated aliphatic carboxylic acids having from 6 to 22 carbon atoms and salts thereof, sulfurized unsaturated esters of aliphatic carboxylic acids having 1 to 22 carbon atoms, sulfurized polymerized unsaturated fatty acids and salts and esters thereof, and mixtures thereof, c) a sulfurized hydrocarbon and d) an aliphatic ester of a dialkyldithiocarbamic acid.

  本发明提供的水性加工液组合物，特别是水性金属加工液组合物，在对金属和固态非金属工件进行机械成型和加工时，能更好地减少摩擦力和作用力。这些组合物包括：a) 水；b) 硫化有机物，该有机物选自具有 6 至 22 个碳原子的硫化不饱和脂肪族羧酸及其盐、具有 1 至 22 个碳原子的脂肪族羧酸的硫化不饱和酯、硫化聚合不饱和脂肪酸及其盐和酯以及它们的混合物组成的组；c) 硫化烃；d) 二烷基二硫代氨基甲酸的脂肪族酯。
• Exploring the Structural Requirements for Inhibition of the Ubiquitin E3 Ligase Breast Cancer Associated Protein 2 (BCA2) as a Treatment for Breast Cancer
  作者：Ghali Brahemi、Fathima R. Kona、Annalisa Fiasella、Daniela Buac、Jitka Soukupová、Andrea Brancale、Angelika M. Burger、Andrew D. Westwell

  DOI：10.1021/jm901757t

  日期：2010.4.8

  The zinc-ejecting aldehyde dehydrogenase (A LDH) inhibitory drug disulfiram (DS F) was found to be a breast cancer-associated protein 2 (BCA2) inhibitor with potent antitumor activity. We herein describe our work in the synthesis and evaluation of new series of zinc-affinic molecules to explore the structural requirements for selective BCA2-inhibitory antitumor activity. An N(C=S)S-S motif was found to be required, based on selective activity in BCA2-expressing breast cancer cell lines and against recombinant BCA2 protein. Notably, the DSF analogs (3a and 3c) and dithio(peroxo)thioate compounds (5d and 5f) were found to have potent activity (submicromolar IC(50)) in BCA2 positive MCF-7 and T47D cells but were inactive (IC(50)> 10 mu M) in BCA2 negative M DA-MB-231 breast cancer cells and the normal breast epithelial cell line MCF10A. Testing in the isogenic BCA2 +ve M DA-MB-231/ER cell line restored antitumor activity for compounds that were inactive in the BCA2 -ve MDA-MB-231 cell line. In contrast, structurally related dithiocarbamates and benzisothiazolones (lacking the disulfide bond) were all inactive. Compounds 5d and 5f were additionally found to lack ALDH-inhibitory activity, suggestive of selective E3 ligase-inhibitory activity and worthy of further development.
• LUBRICATING OIL COMPOSITION
  申请人：Showa Shell Sekiyu K. K.

  公开号：EP2092046A1

  公开（公告）日：2009-08-26
• US4086226A
  申请人：——

  公开号：US4086226A

  公开（公告）日：1978-04-25
• US5391310A
  申请人：——

  公开号：US5391310A

  公开（公告）日：1995-02-21