sodium cyclopropanethiolate | 1111269-88-5

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 英文名称: sodium cyclopropanethiolate
• 英文别名: sodium;cyclopropanethiolate
• CAS: 1111269-88-5
• 化学式: C₃H₅S*Na
• 分子量: 96.1285
• InChiKey: PDVVLVNLVAOGPS-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  5
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,6-二氯吡啶-4-甲酸叔丁酯 、 sodium cyclopropanethiolate 在 sodium hydride 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 生成 2-chloro-6-cyclopropylsulfanyl-isonicotinic acid tert-butyl ester
  参考文献：
  名称：

  [EN] PYRROLIDINE DERIVATIVES USEFUL AS BACE INHIBITORS
  [FR] INHIBITEURS DE LA BACE

  摘要：

  公开号：

  WO2005108358A3

文献信息

• [EN] NOVEL HETEROARYL-TRIAZOLE COMPOUNDS AS PESTICIDES<br/>[FR] NOUVEAUX COMPOSÉS HÉTÉROARYLE-TRIAZOLE EN TANT QUE PESTICIDES
  申请人：BAYER AG

  公开号：WO2021105091A1

  公开（公告）日：2021-06-03

  The present invention relates to novel heteroaryl-triazole compounds of the general formula (I), in which the structural elements X, R1, R2, R3, R4 and R5 have the meaning given in the description, to formulations and compositions comprising such compounds and for their use in the control of animal pests including arthropods and insects in plant protection and to their use for control of ectoparasites on animals.

  本发明涉及一种新颖的杂环芳基-三唑化合物，其一般式为（I），其中结构元素X、R1、R2、R3、R4和R5的含义如描述中所述，以及包含这些化合物的配方和组合物，用于控制包括节肢动物和昆虫在内的动物害虫，用于植物保护，并用于控制动物体表寄生虫。
• [EN] NOVEL HETEROARYL-TRIAZOLE COMPOUNDS AS PESTICIDES<br/>[FR] NOUVEAUX COMPOSÉS HÉTÉROARYLE-TRIAZOLE UTILISÉS COMME PESTICIDES
  申请人：BAYER AG

  公开号：WO2021013720A1

  公开（公告）日：2021-01-28

  The present invention relates to novel heteroaryl-triazole and heteroaryl-tetrazole compounds of the general formula (I), in which the structural elements R1, R2, R3, R4 and R5 have the meaning given in the description, to formulations and compositions comprising such compounds and for their use in the control of animal pests including arthropods and insects in plant protection and to their use for control of ectoparasites on animals.

  本发明涉及一种新型杂环基三唑和杂环基四唑化合物，其一般式为（I），其中结构元素R1、R2、R3、R4和R5的含义如描述中所述，以及包含这些化合物的配方和组合物，用于控制包括节肢动物和昆虫在内的动物害虫，以及用于控制动物体表寄生虫。
• Pyridones as glucokinase activators: Identification of a unique metabolic liability of the 4-sulfonyl-2-pyridone heterocycle
  作者：Jeffrey A. Pfefferkorn、Jihong Lou、Martha L. Minich、Kevin J. Filipski、Mingying He、Ru Zhou、Syed Ahmed、John Benbow、Angel-Guzman Perez、Meihua Tu、John Litchfield、Raman Sharma、Karen Metzler、Francis Bourbonais、Cong Huang、David A. Beebe、Peter J. Oates

  DOI：10.1016/j.bmcl.2009.04.107

  日期：2009.6

  A promising area of novel anti-diabetic therapy involves identification of small molecule activators of the glucokinase enzyme to reduce blood glucose and normalize glucose stimulated insulin secretion. Herein, we report the identification and optimization of a series of 4-sulfonyl-2-pyridone activators. The activators were evaluated for in vitro biochemical activation and pharmacokinetic properties. As part of these efforts, a unique metabolic liability of the 4-sulfonyl-2-pyridone ring system was identified wherein this heterocycle readily undergoes conjugation with glutathione under non-enzymatic conditions. (C) 2009 Elsevier Ltd. All rights reserved.
• INHIBITORS OF RIPK2 AND MEDICAL USES THEREOF
  申请人：[en]ODYSSEY THERAPEUTICS, INC.

  公开号：WO2024112854A1

  公开（公告）日：2024-05-30

  The present disclosure relates to RIPK2 inhibitors represented by structural formula (I). The disclosure further relates to pharmaceutical composition comprising the RIPK2 inhibitors and methods of treatment of conditions such as inflammatory diseases, autoimmune diseases, granulomatous disease, neurodegenerative disesase and cancer.