3β-(4-methylthiophenyl)tropane-2β-carboxylic acid methyl ester | 1186233-78-2

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 托烷生物碱
• 英文名称: 3β-(4-methylthiophenyl)tropane-2β-carboxylic acid methyl ester
• 英文别名: methyl (1R,2S,3S,5S)-8-methyl-3-(4-methylsulfanylphenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate
• CAS: 1186233-78-2
• 化学式: C₁₇H₂₃NO₂S
• 分子量: 305.441
• InChiKey: NGSZLOCYHZRIMB-XZDPQHSOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  54.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3β-(4-methylthiophenyl)tropane-2β-carboxylic acid methyl ester 在 双氧水 、 溶剂黄146 作用下， 反应 20.0h， 以84%的产率得到3β-(4-methylsulfonylphenyl)tropane-2β-carboxylic acid methyl ester
  参考文献：
  名称：

  Synthesis and structure–activity relationship of 3β-(4-alkylthio, -methylsulfinyl, and -methylsulfonylphenyl)tropane and 3β-(4-alkylthiophenyl)nortropane derivatives for monoamine transporters

  摘要：

  Early studies led to the identification of 3 beta-(4-methoxyphenyl)tropane-2 beta-carboxylic acid methyl ester (5) with high affinity at the DAT (IC(50) = 6.5 nM) and 5-HTT (K(i) = 4.3 nM), while having much less affinity at the NET (K(i) = 1110 nM). In the present study, we replaced the 4'-methoxy group of the 3 beta-phenyl ring with a bioisosteric 4'-methylthio group to give 7a. We also synthesized a number of 3 beta-(4-alkylthiophenyl)tropanes 7b-e, 3 beta-(4-methylsulfinylphenyl) and 3 beta-(4-methylsulfonylphenyl)tropane analogues 7f-h as well as the 3 beta-(4-alkylthiophenyl)nortropane derivatives 8-11 to further characterize the structure-activity relationship of this type of compound for binding at monoamine transporters. With exception of the 4'-methylsulfonyl analogue 7h, all the tested compounds possessed high binding affinities at the 5-HTT. The K(i) values ranged from 0.19 nM to 49 nM. The 3 beta-(4-methylthiophenyl)tropane 7a and its N-(3-fluoropropyl) analogue 9a and N- allyl analogue 10a are the most selective compounds for the 5-HTT over the NET (NET/5-HTT = 314-364) in the series. However, none of the compounds showed selectivity similar to 5 for both the DAT and 5-HTT relative to the NET. This study provided useful SAR information for rational design of potent and selective monoamine transporter inhibitors. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.05.052
• 作为产物：
  描述：

  4-溴茴香硫醚 、 脱水芽子碱甲基酯甲磺酸盐 在 碘 、 magnesium 、 1,2-二溴乙烷 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 1.5h， 以87%的产率得到3β-(4-methylthiophenyl)tropane-2β-carboxylic acid methyl ester
  参考文献：
  名称：

  Synthesis and structure–activity relationship of 3β-(4-alkylthio, -methylsulfinyl, and -methylsulfonylphenyl)tropane and 3β-(4-alkylthiophenyl)nortropane derivatives for monoamine transporters

  摘要：

  Early studies led to the identification of 3 beta-(4-methoxyphenyl)tropane-2 beta-carboxylic acid methyl ester (5) with high affinity at the DAT (IC(50) = 6.5 nM) and 5-HTT (K(i) = 4.3 nM), while having much less affinity at the NET (K(i) = 1110 nM). In the present study, we replaced the 4'-methoxy group of the 3 beta-phenyl ring with a bioisosteric 4'-methylthio group to give 7a. We also synthesized a number of 3 beta-(4-alkylthiophenyl)tropanes 7b-e, 3 beta-(4-methylsulfinylphenyl) and 3 beta-(4-methylsulfonylphenyl)tropane analogues 7f-h as well as the 3 beta-(4-alkylthiophenyl)nortropane derivatives 8-11 to further characterize the structure-activity relationship of this type of compound for binding at monoamine transporters. With exception of the 4'-methylsulfonyl analogue 7h, all the tested compounds possessed high binding affinities at the 5-HTT. The K(i) values ranged from 0.19 nM to 49 nM. The 3 beta-(4-methylthiophenyl)tropane 7a and its N-(3-fluoropropyl) analogue 9a and N- allyl analogue 10a are the most selective compounds for the 5-HTT over the NET (NET/5-HTT = 314-364) in the series. However, none of the compounds showed selectivity similar to 5 for both the DAT and 5-HTT relative to the NET. This study provided useful SAR information for rational design of potent and selective monoamine transporter inhibitors. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.05.052

文献信息

• [EN] PREPARATION OF RADIOIODINATED 3-FLUOROPROPYL-NOR-BETA-CIT<br/>[FR] PRÉPARATION DE 3-FLUOROPROPYL-NOR-BETA-CIT RADIO-IODÉ
  申请人：MALLINCKRODT LLC

  公开号：WO2015048250A1

  公开（公告）日：2015-04-02

  The invention generally provides processes for the preparation of radioiodinated 3-fluoropropyl-nor-β-CIT. In particular, the process uses an arylsilane intermediate, thus avoiding the use of hexamethylditin, and reducing the number of steps previously required for the preparation of radioiodinated 3-fluoropropyl-nor-β-CIT from anhydroecgonine methyl ester. The invention also relates to the alkylation of a nortropane to the corresponding N-(3-fluoropropyl) analogue using 3-fluoropropanal.