4-dibenzo[3,4;6,7]cyclohepta[1,2-c]furan-8-ylidene-piperidine | 62591-47-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 环七呋喃
• 英文名称: 4-dibenzo[3,4;6,7]cyclohepta[1,2-c]furan-8-ylidene-piperidine
• 英文别名: 4-(4-Oxatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),2,5,7,9,11,14,16-octaen-13-ylidene)piperidine
• CAS: 62591-47-3
• 化学式: C₂₂H₁₉NO
• 分子量: 313.399
• InChiKey: JSLRMRKDRCSUSS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  24
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  25.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-(1,4-dihydro-1,4-epioxido-tribenzo[a,c,e]cyclohepten-9-ylidene)-1-methyl-piperidine 在 四苯基环戊二烯酮 作用下， 以 xylene 为溶剂， 生成 4-dibenzo[3,4;6,7]cyclohepta[1,2-c]furan-8-ylidene-piperidine
  参考文献：
  名称：

  A comparison of the antiserotonin, antihistamine, and anticholinergic activity of cyproheptadine with analogs having furan nuclei fused to the 10,11-vinylene bridge

  摘要：

  A series of cyproheptadine derivatives having furan nuclei fused to the 10,11-vinylene bridge has been prepared. None of the compounds retain the potent antiserotonin and antihistaminic actions of cyproheptadine. 1-methyl-4-(1-methyl-8H-dibenzo[a,e]furo[3,4-c]cyclohepten-8-ylidene)piperidine (7), 1-methyl-4-(1,3-dihydro-1-oxo-8H-[3,4:6,7]cycloheptal[1,2-c]furan-8-ylidene)piperidine (10), and its reduction product 11 retained the peripheral anticholinergic activity of cyproheptadine.

  DOI：

  10.1021/jm00216a020

文献信息

• REMY D. C.; RAAB A. W.; RITTLE K. E.; ENGELHARDT E. L.; SCRIABINE A.; LOT+, J. MED. CHEM. <JMCM-AR>, 1977, 20, NO 6, 836-838
  作者：REMY D. C.、 RAAB A. W.、 RITTLE K. E.、 ENGELHARDT E. L.、 SCRIABINE A.、 LOT+

  DOI：——

  日期：——
• A comparison of the antiserotonin, antihistamine, and anticholinergic activity of cyproheptadine with analogs having furan nuclei fused to the 10,11-vinylene bridge
  作者：David C. Remy、Andrew W. Raab、Kenneth E. Rittle、Edward L. Engelhardt、Alexander Scriabine、Victor J. Lotti

  DOI：10.1021/jm00216a020

  日期：1977.6

  A series of cyproheptadine derivatives having furan nuclei fused to the 10,11-vinylene bridge has been prepared. None of the compounds retain the potent antiserotonin and antihistaminic actions of cyproheptadine. 1-methyl-4-(1-methyl-8H-dibenzo[a,e]furo[3,4-c]cyclohepten-8-ylidene)piperidine (7), 1-methyl-4-(1,3-dihydro-1-oxo-8H-[3,4:6,7]cycloheptal[1,2-c]furan-8-ylidene)piperidine (10), and its reduction product 11 retained the peripheral anticholinergic activity of cyproheptadine.