6-O-[(1S)-1-[6-[[tert-butyl(dimethyl)silyl]oxymethyl]pyridin-2-yl]ethyl] 2-O-[(1R)-1-[6-(trityloxymethyl)pyridin-2-yl]ethyl] pyridine-2,6-dicarboxylate | 207735-41-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 6-O-[(1S)-1-[6-[[tert-butyl(dimethyl)silyl]oxymethyl]pyridin-2-yl]ethyl] 2-O-[(1R)-1-[6-(trityloxymethyl)pyridin-2-yl]ethyl] pyridine-2,6-dicarboxylate
• CAS: 207735-41-9
• 化学式: C₄₈H₅₁N₃O₆Si
• 分子量: 794.035
• InChiKey: ISHHTQYLGONOGI-GPOMZPHUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.74
• 重原子数：
  58
• 可旋转键数：
  18
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  110
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  6-O-[(1S)-1-[6-[[tert-butyl(dimethyl)silyl]oxymethyl]pyridin-2-yl]ethyl] 2-O-[(1R)-1-[6-(trityloxymethyl)pyridin-2-yl]ethyl] pyridine-2,6-dicarboxylate 在 zinc dibromide 作用下， 以 二氯甲烷 为溶剂， 反应 0.17h， 以88%的产率得到Pyridine-2,6-dicarboxylic acid 2-{(S)-1-[6-(tert-butyl-dimethyl-silanyloxymethyl)-pyridin-2-yl]-ethyl} ester 6-[(R)-1-(6-hydroxymethyl-pyridin-2-yl)-ethyl] ester
  参考文献：
  名称：

  Ag⁺-Specific Pyridine Podands:  Effects of Ligand Geometry and Stereochemically Controlled Substitution on Cation Complexation and Transport Functions

  摘要：

  A new series of acyclic podands was designed so that three pyridine moieties cooperatively bind a guest Ag(+). Liquid-Liquid extraction, NMR binding, and computer calculation experiments reveal that podands with three pyridine donors in a proper geometry exhibit a perfect Ag(+) specificity. They selectively extracted Ag+ in the presence of equimolar Pb(2+), CU(2+), Ni(2+), Co(2+), and Zn(2+). Introduction of two chiral centers close to the pyridine binding sites surprisingly influences the Ag(+)-binding ability of the podand. Fourteen new pyridine podands were evaluated as carriers in a liquid membrane transport system. A combination of ligand geometry and stereocontrolled substitution provides excellent Ag(+)-specific transport.

  DOI：

  10.1021/jo9721148
• 作为产物：
  描述：

  2,6-氯甲酰吡啶 、 (1S)-1-[6-[[tert-butyl(dimethyl)silyl]oxymethyl]pyridin-2-yl]ethanol 、 (1R)-1-[6-(trityloxymethyl)pyridin-2-yl]ethanol 在 三乙胺 作用下， 生成 6-O-[(1S)-1-[6-[[tert-butyl(dimethyl)silyl]oxymethyl]pyridin-2-yl]ethyl] 2-O-[(1R)-1-[6-(trityloxymethyl)pyridin-2-yl]ethyl] pyridine-2,6-dicarboxylate 、 bis[(1S)-1-[6-[[tert-butyl(dimethyl)silyl]oxymethyl]pyridin-2-yl]ethyl] pyridine-2,6-dicarboxylate
  参考文献：
  名称：

  Ag⁺-Specific Pyridine Podands:  Effects of Ligand Geometry and Stereochemically Controlled Substitution on Cation Complexation and Transport Functions

  摘要：

  A new series of acyclic podands was designed so that three pyridine moieties cooperatively bind a guest Ag(+). Liquid-Liquid extraction, NMR binding, and computer calculation experiments reveal that podands with three pyridine donors in a proper geometry exhibit a perfect Ag(+) specificity. They selectively extracted Ag+ in the presence of equimolar Pb(2+), CU(2+), Ni(2+), Co(2+), and Zn(2+). Introduction of two chiral centers close to the pyridine binding sites surprisingly influences the Ag(+)-binding ability of the podand. Fourteen new pyridine podands were evaluated as carriers in a liquid membrane transport system. A combination of ligand geometry and stereocontrolled substitution provides excellent Ag(+)-specific transport.

  DOI：

  10.1021/jo9721148