N-(5-{4-[7-(3-dimethylamino-propoxy)-6-methoxy-quinolin-4-yloxy]-3-fluoro-phenylsulfamoyl}-4-methyl-thiazol-2-yl)acetamide | 1293292-03-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-(5-{4-[7-(3-dimethylamino-propoxy)-6-methoxy-quinolin-4-yloxy]-3-fluoro-phenylsulfamoyl}-4-methyl-thiazol-2-yl)acetamide
• 英文别名: N-[5-[[4-[7-[3-(dimethylamino)propoxy]-6-methoxyquinolin-4-yl]oxy-3-fluorophenyl]sulfamoyl]-4-methyl-1,3-thiazol-2-yl]acetamide
• CAS: 1293292-03-1
• 化学式: C₂₇H₃₀FN₅O₆S₂
• 分子量: 603.696
• InChiKey: ISBDGVKJWNJPQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  41
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  169
• 氢给体数：
  2
• 氢受体数：
  12

文献信息

• [EN] QUINOLINYLOXYPHENYLSULFONAMIDES<br/>[FR] QUINOLINYLOXYPHÉNYLSULFONAMIDES
  申请人：MAX PLANCK GESELLSCHAFT

  公开号：WO2011045084A1

  公开（公告）日：2011-04-21

  The present invention relates to quinolinyloxyphenylsulfonamides and stereoisomeric forms, solvates, hydrates and/or pharmaceutically acceptable salts of these quinolinyloxyphenylsulfonamide compounds as well as pharmaceutical compositions containing at least one of these compounds together with at least one pharmaceutically acceptable carrier, excipient and/or diluent. Said quinolinyloxyphenylsulfonamides are useful for prophylaxsis, treatment and/or after-treatment of hyperproliferative disorders, such as cancer, tumors and particularly cancer metastases.

  本发明涉及喹啉氧基苯磺酰胺及其立体异构体形式、溶剂化物、水合物和/或这些喹啉氧基苯磺酰胺化合物的药学上可接受的盐，以及含有至少一种这些化合物和至少一种药学上可接受的载体、赋形剂和/或稀释剂的制剂。所述喹啉氧基苯磺酰胺对于预防、治疗和/或后治疗增生性疾病，如癌症、肿瘤，特别是癌症转移，具有有用的作用。
• QUINOLINYLOXYPHENYLSULFONAMIDES
  申请人：Ullrich Axel

  公开号：US20120277231A1

  公开（公告）日：2012-11-01

  The present invention relates to quinolinyloxyphenylsulfonamides and stereoisomeric forms, solvates, hydrates and/or pharmaceutically acceptable salts of these quinolinyloxyphenylsulfonamide compounds as well as pharmaceutical compositions containing at least one of these compounds together with at least one pharmaceutically acceptable carrier, excipient and/or diluent. Said quinolinyloxyphenylsulfonamides are useful for prophylaxsis, treatment and/or after-treatment of hyperproliferative disorders, such as cancer, tumors and particularly cancer metastases.

  本发明涉及喹啉氧基苯磺酰胺及其立体异构体、溶剂化物、水合物和/或药学上可接受的盐，以及至少包含其中一种化合物和至少一种药学上可接受的载体、赋形剂和/或稀释剂的制药组合物。所述喹啉氧基苯磺酰胺对于预防、治疗和/或后治疗增生性疾病，如癌症、肿瘤和特别是癌症转移，具有有用的作用。
• US9169241B2
  申请人：——

  公开号：US9169241B2

  公开（公告）日：2015-10-27