[Pt(isobutylenediamine)Cl2] | 99008-46-5

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 英文名称: [Pt(isobutylenediamine)Cl2]
• 英文别名: {PtibnCl2}；[Pt(isobutylenediamine)Cl₂]；[Pt(ibn)Cl₂]
• CAS: 99008-46-5
• 化学式: C₄H₁₂Cl₂N₂Pt
• 分子量: 354.139
• InChiKey: HWZJIWMCXPCOGB-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  [Pt(isobutylenediamine)Cl2] 、 1,2-二氨基-2-甲基丙烷 以 水 为溶剂， 生成 {Ptibn2}Cl2
  参考文献：
  名称：

  Drew, H. D. K.; Head, F. S. H., Journal of the Chemical Society

  摘要：

  DOI：
• 作为产物：
  描述：

  、 potassium chloride 在 silver nitrate 作用下， 生成 [Pt(isobutylenediamine)Cl2]
  参考文献：
  名称：

  系列阳离子双核Pt(II)配合物的体外和体内活性

  摘要：

  [{Pt( L )Cl} 2 ( μ -X)] 2+类型的九种双核铂(II)配合物的抗肿瘤潜力（其中L代表两个NH 3或不同的双齿配位二胺配体-乙二胺，en；（ ±)-1,2-丙二胺，1,2-pn；异丁二胺，ibn；反式-(±)-1,2-二氨基环己烷，dach；1,3-丙二胺，2,2-二甲基； -1,3-丙二胺，2,2-diMe-1,3-pd；(±)-1,3-戊二胺，1,3-pnd，X是桥联吡嗪(pz)或哒嗪(pydz)配体）通过使用 CT26 细胞系和在免疫活性 BALB/c 小鼠中诱导的异位结肠癌肿瘤小鼠模型进行体外和体内测定来确定。本研究得出的结论是，复合物Pt1 、 Pt2和Pt7对小鼠结肠癌CT26细胞具有显着的体外细胞毒活性，同时所有这些复合物都显示出中等的细胞凋亡作用。复合物Pt1和Pt7将CT26细胞阻滞在细胞周期的G2/M期，而通过检测Ki67表达细胞进行评估，复合物Pt

  DOI：

  10.1016/j.jinorgbio.2021.111619

文献信息

• Mills, W. H.; Quibell, T. H. E., Journal of the Chemical Society
  作者：Mills, W. H.、Quibell, T. H. E.

  DOI：——

  日期：——
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Pt: MVol.D, 72, page 176 - 178
  作者：

  DOI：——

  日期：——
• Synthesis of different pyrazine-bridged platinum(II) complexes and 1H NMR study of their catalytic abilities in the hydrolysis of the N-acetylated l-methionylglycine
  作者：Snežana Rajković、Darko P. Ašanin、Marija D. Živković、Miloš I. Djuran

  DOI：10.1016/j.poly.2013.08.016

  日期：2013.11

  Four binuclear [Pt(L)Cl](2)(mu-pz)}Cl-2-type complexes have been synthesized and characterized by elemental microanalyses and NMR (H-1 and C-13) spectroscopy (L is ethylenediamine, en; (+/-)-1,2-propylenediamine, 1,2-pn; isobutylenediamine, ibn; trans-(+/-)-1,2-diaminocyclohexane, dach and pz is bridging pyrazine ligand). The chlorido complexes were converted into the corresponding aqua species, [Pt(L) (H2O)](2)(mu-pz)}(4+), and H-1 NMR spectroscopy was applied to study their reactions with the N-acetylated L-methionylglycine, Ac-L-Met-Gly. The [Pt(L)(H2O)](2)(mu-pz)}(4+) complex and dipeptide were reacted in 1:1 and 1:2 M ratios, respectively, and all reactions were performed in the pH range 2.0-2.5 and at 37 degrees C. In the reactions with equimolar amounts of the reactants all Pt(II) aqua complexes bind to the methionine side chain of Ac-L-Met-Gly dipeptide and promote the cleavage of the amide bond involving the carboxylic group of methionine. It was found that the amount of hydrolyzed dipeptide strongly depends from the steric bulk of bidentate coordinated diamine ligand L in [Pt(L)(H2O)](2)(mu-pz)}(4+) complex (en > 1,2-pn > ibn > dach). However, in the reaction with an excess of dipeptide the influence of the nature of diamine ligand L on this hydrolytic process could not be observed due to the fact that slow decomposition of [Pt(L)(H2O)](2)(mu-pz)}(4+) complex was occured. (C) 2013 Elsevier Ltd. All rights reserved.
• Synthesis and Evaluation of Series of Diazine-Bridged Dinuclear Platinum(II) Complexes through in Vitro Toxicity and Molecular Modeling: Correlation between Structure and Activity of Pt(II) Complexes
  作者：Lidija Senerovic、Marija D. Zivkovic、Aleksandar Veselinovic、Aleksandar Pavic、Milos I. Djuran、Snezana Rajkovic、Jasmina Nikodinovic-Runic

  DOI：10.1021/jm5017686

  日期：2015.2.12

  Polynuclear Pt(II) complexes are a novel class of promising anticancer agents with potential clinical significance. A series of pyrazine (pz) bridged dinuclear Pt(II) complexes with general formulas [Pt(L)Cl](2)(mu-pz)}(2+) (L, ethylenediamine, en; (+/-)-1,2-propylenediamine, 1,2-pn; isobutylenediamine, ibn; trans-(+/-)-1,2-diaminocyclohexane, dach; 1,3-propylenediamine, 1,3-pd; 2,2-dimethyl-1,3-propylenediamine, 2,2-diMe-1,3-pd) and one pyridazine (pydz) bridged [Pt(en)Cl](2)(mu-pydz)}(2+) complex were prepared. The anticancer potential of these complexes were determined through in vitro cytotoxicity assay in human fibroblasts (MRC5) and two carcinoma cell lines (A375 and HCT116), interaction with double stranded DNA through in vitro assay, and molecular docking study. All complexes inhibited cell proliferation with inhibitory concentrations in the 0.5-120 mu M range. While [Pt(1,3-pd)Cl](2)(mu-pz)}(2+) showed improved activity and [Pt(en)Cl](2)(mu-pydz)}(2+) showed comparable activity to that of clinically relevant cisplatin, [Pt(en)Cl](2)(mu-pydz)}(2+) was less toxic in an assay with zebrafish (Danio rerio) embryos, causing no adverse developmental effects. The in vitro cytotoxicity of all diazine-bridged dinuclear Pt(II) complexes is discussed in correlation to their structural characteristics.
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Pt: MVol.D, 121, page 275 - 277
  作者：

  DOI：——

  日期：——