(R)-N-(2-(1H-pyrazol-1-yl)benzyl)-8-isopropyl-2-(piperidin-3-yloxy)pyrazolo[1,5-a][1,3,5]triazin-4-amine | 1453832-84-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: (R)-N-(2-(1H-pyrazol-1-yl)benzyl)-8-isopropyl-2-(piperidin-3-yloxy)pyrazolo[1,5-a][1,3,5]triazin-4-amine
• 英文别名: 2-[(3R)-piperidin-3-yl]oxy-8-propan-2-yl-N-[(2-pyrazol-1-ylphenyl)methyl]pyrazolo[1,5-a][1,3,5]triazin-4-amine
• CAS: 1453832-84-2
• 化学式: C₂₃H₂₈N₈O
• 分子量: 432.528
• InChiKey: LSGRZENCFIIHNV-GOSISDBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  94.2
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Pyrazolo-triazine derivatives as selective cyclin-dependent kinase inhinitors
  申请人：Lead Discovery Center GmbH

  公开号：EP2634190A1

  公开（公告）日：2013-09-04

  The present invention relates to pyrazolo[1,5-a][1,3,5]triazine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, immunological diseases, autoimmune diseases, cardiovascular diseases, cell proliferative diseases, inflammation, erectile dysfunction and stroke, and pharmaceutical compositions containing at least one of said pyrazolo[1,5-a][1,3,5]triazine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said pyrazolo[1,5-a][1,3,5]triazine derivatives as inhibitors for a protein kinase.

  本发明涉及吡唑并[1,5-a][1,3,5]三嗪衍生物和/或其药用可接受盐，以及这些衍生物作为药用活性剂的用途，特别是用于预防和/或治疗传染病，包括机会性疾病、免疫疾病、自身免疫疾病、心血管疾病、细胞增殖性疾病、炎症、勃起功能障碍和中风，以及含有至少一种所述吡唑并[1,5-a][1,3,5]三嗪衍生物和/或其药用可接受盐的药物组合物。此外，本发明涉及将所述吡唑并[1,5-a][1,3,5]三嗪衍生物用作蛋白激酶的抑制剂。
• [EN] TRICYCLIC PYRIMIDINES AS CYCLIN-DEPENDENT KINASE 7 (CDK7) INHIBITORS<br/>[FR] PYRIMIDINES TRICYCLIQUES UTILISÉES EN TANT QU'INHIBITEURS DE LA KINASE 7 DÉPENDANTE DES CYCLINES (CDK7)
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2022136174A1

  公开（公告）日：2022-06-30

  The invention relates to pharmaceutical compounds of formula (I) and pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds as inhibitors of cyclin-dependent kinase 7 (CDK7) and to their use in the treatment of diseases, e.g., cancer.

  本发明涉及公式（I）的药物化合物和包含该化合物的药物组合物，涉及制备该化合物的过程以及将该化合物用作细胞周期素依赖性激酶7（CDK7）的抑制剂并用于治疗疾病，例如癌症。
• PYRAZOLO - TRIAZINE DERIVATIVES AS SELECTIVE CYCLIN- DEPENDENT KINASE INHINITORS
  申请人：Lead Discovery Center GmbH

  公开号：EP2820020A1

  公开（公告）日：2015-01-07
• PYRAZOLO-TRIAZINE DERIVATIVES AS SELECTIVE CYCLIN-DEPENDENT KINASE INHIBITORS
  申请人：Lead Discovery Center GmbH

  公开号：EP2820020B1

  公开（公告）日：2016-04-06
• METHOD FOR EFFICIENT GENERATION OF NEURONS FROM NON-NEURONAL CELLS
  申请人：Massachusetts Institute of Technology

  公开号：US20200123499A1

  公开（公告）日：2020-04-23

  This disclosure provides, in part, methods and compositions relating to the genetic reprogramming of non-neuronal cells into neuronal cells. The disclosure further methods and compositions relating to reprogramming neural cells away from the neural fate.