4-Acetyl-1,4-diaza-bicyclo<4.4.0>decan | 24025-09-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌嗪基哌啶类
• 英文名称: 4-Acetyl-1,4-diaza-bicyclo<4.4.0>decan
• 英文别名: 2-acetyl-octahydro-pyrido[1,2-a]pyrazine；1-(1,3,4,6,7,8,9,9a-Octahydropyrido[1,2-a]pyrazin-2-yl)ethanone
• CAS: 24025-09-0
• 化学式: C₁₀H₁₈N₂O
• 分子量: 182.266
• InChiKey: FNFABVSADGGDMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• HETEROCYCLIC COMPOUND HAVING TYPE I 11 BETA HYDROXYSTEROID DEHYDROGENASE INHIBITORY ACTIVITY
  申请人：SHIONOGI & CO., LTD.

  公开号：EP1894919A1

  公开（公告）日：2008-03-05

  Disclosed is a compound useful as a type I 11 β hydroxysteroid dehydrogenase inhibitor. A compound represented by the formula: a pharmaceutically acceptable salt or solvate thereof, wherein R1 is optionally substituted cycloalkyl, optionally substituted cycloalkenyl or the like, One of R2 and R3 is a group of the formula: -C(=O)-Y-R4, wherein Y is -NR9- or the like, R4 is optionally substituted cycloalkyl or the like, R9 is hydrogen or optionally substituted alkyl, W is optionally substituted alkylene, The other is a group of the formula: -V-R5, wherein Vis a bond, -O- or the like, R6 is hydrogen or optionally substituted alkyl, R5 is hydrogen, optionally substituted alkyl or the like, X is a bond, -S-, -SO- or the like, U is a bond or optionally substituted alkylene, R7 is hydrogen or optionally substituted alkyl, Zis-S-,-O-or-NR8-, R8 is hydrogen, optionally substituted alkyl or the like.

  本发明公开了一种可用作 I 型 11 β 羟类固醇脱氢酶抑制剂的化合物。 一种由式表示的化合物： 其药学上可接受的盐或溶液、 其中 R1 是任选取代的环烷基、任选取代的环烯基或类似物、 R2 和 R3 中的一个是式中的基团：-C(=O)-Y-R4、 其中 Y 是 -NR9- 或类似基团、 R4 是任选取代的环烷基或类似基团、 R9 是氢或任选取代的烷基、 W 是任选取代的亚烷基、 另一个是式中的基团：-V-R5、 其中，Vis 是键、-O- 或类似基团、 R6 是氢或任选取代的烷基、 R5 是氢、任选取代的烷基或类似物、 X 是键、-S-、-SO- 或类似物、 U 是键或任选取代的亚烷基、 R7 是氢或任选取代的烷基、 Z是-S-、-O-或-NR8-、 R8 是氢、任选取代的烷基或类似物。
• ISOXAZOLE DERIVATIVE AND ISOTHIAZOLE DERIVATIVE HAVING INHIBITORY ACTIVITY ON 11(beta)-HYDROXYSTEROID DEHYDROGENASE TYPE I
  申请人：Ogawa Tomoyuki

  公开号：US20090131491A1

  公开（公告）日：2009-05-21

  Disclosed is a compound useful as an inhibitor of 11β-hydroxysteroid dehydrogenase type 1. A compound represented by the formula: a pharmaceutically acceptable salt or solvate thereof, wherein R 1 is a group of the formula: —C(═O)NR 4 R 5 , (wherein R 4 and R 5 are each independently, hydrogen, optionally substituted alkyl or the like) or a group of the formula: —NR 6 C(═O)R 7 , (wherein R 6 and R 7 are each independently, hydrogen, optionally substituted alkyl or the like), X and Y are each independently —O— or the like, Z is a bond or the like, R 2 is optionally substituted alkyl, optionally substituted alkenyl or the like, R 3 is optionally substituted alkyl, optionally substituted alkenyl or the like.
• SEPIAPTERIN REDUCTASE INHIBITORS
  申请人：QUARTET MEDICINE, INC.

  公开号：US20170096435A1

  公开（公告）日：2017-04-06

  Inhibitors of sepiapterin reductase and uses of sepiapterin reductase inhibitors in analgesia, treatment of acute and chronic pain, anti-inflammation, and immune cell regulation are disclosed.
• US8017638B2
  申请人：——

  公开号：US8017638B2

  公开（公告）日：2011-09-13
• US8952176B2
  申请人：——

  公开号：US8952176B2

  公开（公告）日：2015-02-10