(3S)-1,2-di-tert-butyl 3-ethyl 1H-1,2,4-triazole-1,2,3(3H)-tricarboxylate | 1452589-17-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: (3S)-1,2-di-tert-butyl 3-ethyl 1H-1,2,4-triazole-1,2,3(3H)-tricarboxylate
• CAS: 1452589-17-1
• 化学式: C₁₅H₂₅N₃O₆
• 分子量: 343.38
• InChiKey: ZZKOSWVQWCFTOQ-JTQLQIEISA-N

反应信息

• 作为产物：
  描述：

  偶氮二甲酸二叔丁酯 、 氰乙酸乙酯 在 C₃₂H₂₈F₆N₄O₃ 作用下， 以 氯仿 为溶剂， 反应 72.0h， 生成 (3S)-1,2-di-tert-butyl 3-ethyl 1H-1,2,4-triazole-1,2,3(3H)-tricarboxylate 、 (3R)-1,2-di-tert-butyl 3-ethyl 1H-1,2,4-triazole-1,2,3(3H)-tricarboxylate
  参考文献：
  名称：

  Cinchona Alkaloid Squaramide Catalyzed Enantioselective Hydrazination/Cyclization Cascade Reaction of α-Isocyanoacetates and Azodicarboxylates: Synthesis of Optically Active 1,2,4-Triazolines

  摘要：

  An efficient enantioselective hydrazination/cyclization cascade reaction of alpha-substituted isocyanoacetates to azodicarboxylates catalyzed by Cinchona alkaloid derived squaramide catalysts has been investigated, affording the optically active 1,2,4-triazolines in excellent yields (up to 99%) and good to excellent enantioselectivities (up to 97% ee) under mild conditions.

  DOI：

  10.1021/jo401585v