But-3-ynyl dimethyl phosphate | 1187326-43-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: But-3-ynyl dimethyl phosphate
• CAS: 1187326-43-7
• 化学式: C₆H₁₁O₄P
• 分子量: 178.125
• InChiKey: SKQPXNVGWCOQFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  But-3-ynyl dimethyl phosphate 在 2,4,6-三甲基吡啶 、 三甲基溴硅烷 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 生成 but-3-yn-1-yl monophosphate
  参考文献：
  名称：

  Synthesis and application of photoaffinity probe containing an intact isoprenoid chain

  摘要：

  Two novel chemical probes each carrying an intact isoprenoid chain, a biotin tag and a benzophenone moiety were synthesized. Photoaffinity labeling of the Saccharomyces cerevisiae cell lysate revealed that these probes could selectively trap some proteins, and proteins with molecular weight of similar to 70 KDa appeared as a major band upon Streptavidin blot analysis. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.06.037
• 作为产物：
  描述：

  3-丁炔-1-醇 、 三甲氧基磷 在 吡啶 、 四溴化碳 作用下， 以70%的产率得到But-3-ynyl dimethyl phosphate
  参考文献：
  名称：

  Synthesis and application of photoaffinity probe containing an intact isoprenoid chain

  摘要：

  Two novel chemical probes each carrying an intact isoprenoid chain, a biotin tag and a benzophenone moiety were synthesized. Photoaffinity labeling of the Saccharomyces cerevisiae cell lysate revealed that these probes could selectively trap some proteins, and proteins with molecular weight of similar to 70 KDa appeared as a major band upon Streptavidin blot analysis. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.06.037

文献信息

• POLYNUCLEOTIDE CONSTRUCTS HAVING BIOREVERSIBLE AND NON-BIOREVERSIBLE GROUPS
  申请人：BRADSHAW Curt W.

  公开号：US20170114341A1

  公开（公告）日：2017-04-27

  The invention features a hybridized polynucleotide construct containing a passenger strand, a guide strand loadable into a RISC complex, and (i) a 3′-terminal or an internucleotide non-bioreversible group in the guide strand; or (ii) a 5′-terminal, a 3′-terminal, or an internucleotide non-bioreversible group in the passenger strand, and a 5′-terminal, a 3′-terminal, or an internucleotide disulfide bioreversible group in the guide strand or the passenger strand. The invention also features methods of delivering a polynucleotide to a cell using the hybridized polynucleotide construct. The invention further features methods of reducing the expression of a polypeptide in a cell using the hybridized polynucleotide construct.
• [EN] POLYNUCLEOTIDE CONSTRUCTS HAVING BIOREVERSIBLE AND NON-BIOREVERSIBLE GROUPS<br/>[FR] CONSTRUCTIONS DE POLYNUCLÉOTIDES POSSÉDANT DES GROUPES BIORÉVERSIBLES ET NON BIORÉVERSIBLES
  申请人：SOLSTICE BIOLOG LTD

  公开号：WO2015188197A2

  公开（公告）日：2015-12-10

  The invention features a hybridized polynucleotide construct containing a passenger strand, a guide strand loadable into a RISC complex, and (i) a 3'-terminal or an internucleotide non-bioreversible group in the guide strand; or (ii) a 5'-terminal, a 3'-terminal, or an internucleotide non-bioreversible group in the passenger strand, and a 5'-terminal, a 3'-terminal, or an internucleotide disulfide bioreversible group in the guide strand or the passenger strand. The invention also features methods of delivering a polynucleotide to a cell using the hybridized polynucleotide construct. The invention further features methods of reducing the expression of a polypeptide in a cell using the hybridized polynucleotide construct.