4-(十八烷基氨基)偶氮苯 | 141754-63-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 偶氮苯
• 中文名称: 4-(十八烷基氨基)偶氮苯
• 英文名称: 4-(Octadecylamino)azobenzene
• CAS: 141754-63-4
• 化学式: C₃₀H₄₇N₃
• 分子量: 449.723
• InChiKey: SBAYZFPGULDFNX-ULIFNZDWSA-N

物化性质

• 沸点：
  574.0±33.0 °C(Predicted)
• 密度：
  0.95±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  10.78
• 重原子数：
  33.0
• 可旋转键数：
  20.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  36.75
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  4-(phenylazo)aniline 在 lithium aluminium tetrahydride 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 17.67h， 生成 4-(十八烷基氨基)偶氮苯
  参考文献：
  名称：

  Lead-selective bulk optodes based on neutral ionophores with subnanomolar detection limits

  摘要：

  An optical sensor (optode) based on a plasticized poly(vinyl chloride) (PVC) bulk membrane incorporating a metal ion-selective ionophore, a proton-selective chromoionophore, and lipophilic anionic sites for the measurement of lead is presented. Different ionophores and chromoionophores were used to design a new optode for environmental sensing properties. The present optode system shows an especially excellent selectivity over alkali and alkaline-earth metals. The measuring range for lead was found to be 5.0 X 10(-9) to 5.0 X 10(-3) M at pH 5.68 with a corresponding detection limit of 3.2 X 10(-12) M. This reversibly working optode shows different dynamic ranges depending on the basicity of the chromoionophore and on the pH of the sample solution. Therefore, these sensors can be tailored to a specific application by varying the above mentioned parameters. Dynamic range, detection limit, response behavior, short-time repeatability, stability, and selectivity of the optode systems are discussed. Comparison with polarography shows good agreement.

  DOI：

  10.1021/ac00038a007

文献信息

• Method for the preparation of optical (bio)chemical sensor devices
  申请人：——

  公开号：US20020115224A1

  公开（公告）日：2002-08-22

  The present invention relates to a method for the preparation of a miniaturized optical chemical or biochemical sensor device (e.g. bulk optode, etc. for ion sensing), said device comprising a substrate material having a planar surface portion, said planar surface representing a transducer based on an optical phenomenon such as surface plasmon resonance based on evanescent waves, reflection or transmission; said planar surface portion having arranged thereon an multi-analyte array of (bio)chemical sensor dots located at spatially separated predetermined positions of the planar surface, said sensor dots including (i) a polymer matrix, and (ii) one or more (bio)chemical recognition moieties, the method comprising (a) providing a substrate material having a planar surface portion; (b) providing one or more spotting fluid(s); (c) depositing the one or more spotting fluid(s) onto the planar surface portion of the substrate material by means of a pin-printer deposition mechanism (arrayer) and allowing the spotting fluid(s) to consolidate.

  本发明涉及一种制备微型光学化学或生化传感器装置（如用于离子传感的散装光电极等）的方法。本发明涉及一种用于制备微型化光学化学或生化传感器装置（如用于离子传感的体式光电二极管等）的方法，所述装置包括具有平面表面部分的基底材料，所述平面表面代表基于光学现象（如基于蒸发波、反射或透射的表面等离子体共振）的换能器；所述平面表面部分上排列有位于平面表面空间上分离的预定位置的（生物）化学传感点的多分析阵列，所述传感点包括 (i) 聚合物基质，和 (ii) 一个或多个（生物）化学识别分子，该方法包括 (a) 提供具有平面表面部分的基底材料；(b) 提供一种或多种点阵液； (c) 通过针刺机沉积机构（阵列器）将一种或多种点阵液沉积到基底材料的平面部分上，并使点阵液固化。
• Ion-detecting microspheres and methods of use thereof
  申请人：Auburn University

  公开号：US20040058384A1

  公开（公告）日：2004-03-25

  This invention provides methods of using ion-detecting microspheres containing an ionphore and a chromoionphore in clinical laboratory instrumentation such as flow cytometry for sample analysis. In one embodiment, the microspheres are contacted with a flowing stream of a sample under conditions that allow the ion-selective ionophores to complex with the ions in the sample, and to cause deprotonation of the chromoionophore. The complexes are then exposed to an excitation wavelength light source suitable for exciting the deprotonated chromoionophore to emit a fluorescence signal pattern. Detection of the fluorescence signal pattern emitted by the deprotonated chromoionophore in microspheres containing the complexes allows for determination of the presence of the target ions in the sample. In one embodiment, lead ion-detecting microspheres are provided that can detect nanomolar levels of lead ions with response times on the order of minutes.

  本发明提供了在临床实验室仪器（如流式细胞仪）中使用含有离子亲体和发色团的离子检测微球进行样品分析的方法。在一个实施方案中，将微球与流动的样品流接触，使离子选择性亲离子与样品中的离子复合，并引起亲色团的去质子化。然后将复合物暴露在适合激发去质子化的发色团的激发波长光源下，使其发出荧光信号图案。通过检测含有络合物的微球中去质子化的发色团发出的荧光信号图案，可以确定样品中是否存在目标离子。在一个实施方案中，提供的铅离子检测微球可检测纳摩尔级的铅离子，响应时间约为几分钟。
• METHOD FOR THE PREPARATION OF OPTICAL (BIO)CHEMICAL SENSOR DEVICES
  申请人：Vir A/S

  公开号：EP1360007A1

  公开（公告）日：2003-11-12
• ION-DETECTING MICROSPHERES AND METHODS OF USE THEREOF
  申请人：Bakker Eric

  公开号：US20080173846A1

  公开（公告）日：2008-07-24

  This invention provides methods of using ion-detecting microspheres containing an ionphore and a chromoionphore in clinical laboratory instrumentation such as flow cytometry for sample analysis. In one embodiment, the microspheres are contacted with a flowing stream of a sample under conditions that allow the ion-selective ionophores to complex with the ions in the sample, and to cause deprotonation of the chromoionophore. The complexes are then exposed to an excitation wavelength light source suitable for exciting the deprotonated chromoionophore to emit a fluorescence signal pattern. Detection of the fluorescence signal pattern emitted by the deprotonated chromoionophore in microspheres containing the complexes allows for determination of the presence of the target ions in the sample. In one embodiment, lead ion-detecting microspheres are provided that can detect nanomolar levels of lead ions with response times on the order of minutes.
• US7247489B2
  申请人：——

  公开号：US7247489B2

  公开（公告）日：2007-07-24