1-methoxy-1-trimethylsiloxy-3-tert-butyldimethylsiloxy-1,3-butadiene | 1007309-91-2

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: 1-methoxy-1-trimethylsiloxy-3-tert-butyldimethylsiloxy-1,3-butadiene
• CAS: 1007309-91-2
• 化学式: C₁₄H₃₀O₃Si₂
• 分子量: 302.561
• InChiKey: NLYKMLPAOFQSPJ-UHFFFAOYSA-N

物化性质

• 沸点：
  288.0±30.0 °C(Predicted)
• 密度：
  0.893±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.86
• 重原子数：
  19.0
• 可旋转键数：
  6.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  27.69
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  1-methoxy-1-trimethylsiloxy-3-tert-butyldimethylsiloxy-1,3-butadiene 、 8-chloro-5-methoxy-2-methylbenzo[h]chromene-4,7,10-trione 在 吡啶 作用下， 以 苯 为溶剂， 反应 18.0h， 以40%的产率得到10-(tert-butyldimethylsilyloxy)-8-hydroxy-5-methoxy-2-methyl-1-oxabenzo[a]anthracene-4,7,12-trione
  参考文献：
  名称：

  Synthesis and Biological Activities of Topopyrones

  摘要：

  Structure-activity studies were employed to investigate the stabilization of DNA-topoisomerases I and II covalent binary complexes by topopyrone analogues. The synthesis of five new topopyrone derivatives and study of their ability to stabilize DNA topoisomerase I and DNA-topoisomerase II covalent binary complexes are described. The biochemical assays suggest that the orientation of the fused 1,4-pyrone ring and halogen substituents contribute importantly to the overall potency of the topopyrones as topoisomerase poisons.

  DOI：

  10.1021/np200777z

文献信息

• Total Synthesis of (±)-δ-Rubromycin
  作者：Wenjing Wang、Jijun Xue、Tian Tian、Jie Zhang、Liping Wei、Jidong Shao、Zhixiang Xie、Ying Li

  DOI：10.1021/ol400864f

  日期：2013.5.17

  Transition-metal-catalyzed spiroketalization cyclization has been performed successfully and has led to the first total synthesis of (+/-)-delta-rubromycin with a longest linear sequence of 18 steps from commercially available guaiacol in a 2.7% overall yield.