3,7-二甲基-3-辛醇钠 | 263148-42-1

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 中文名称: 3,7-二甲基-3-辛醇钠
• 英文名称: (1,5-Dimethyl-1-ethylhexyloxy) potassium
• 英文别名: potassium;3,7-dimethyloctan-3-olate
• CAS: 263148-42-1
• 化学式: C10H21KO
• 分子量: 196.37
• InChiKey: RGTULLOKMOQGAQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.65
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Process for the Preparation of Substituted 2-Acetylamino-Alkoxyphenyl
  申请人：Ainge Debra

  公开号：US20100041905A1

  公开（公告）日：2010-02-18

  The present invention relates to a novel process for the preparation of compounds of formula (V) wherein X, Q, R1, R1 a and R2 are as defined in the specification, the compounds being useful in the preparation of therapeutic agents.

  本发明涉及一种新型工艺，用于制备式（V）化合物，其中X、Q、R1、R1a和R2如规范中所定义，这些化合物在制备治疗剂中有用。
• [EN] A NEW PRODUCTION METHOD AND NEW INTERMEDIATES OF SYNTHESIS OF ELVITEGRAVIR<br/>[FR] NOUVEAU PROCÉDÉ DE PRODUCTION ET NOUVEAUX INTERMÉDIAIRES DE SYNTHÈSE D'ELVITEGRAVIR
  申请人：ZENTIVA KS

  公开号：WO2014056464A1

  公开（公告）日：2014-04-17

  The present solution relates to an improved production method of elvitegravir of formula I, which is being clinically evaluated for treatment of HIV infection. Elvitegravir of formula I is produced via the intermediate of formula II, the preparation of which is also an object of the present solution.

  本解决方案涉及一种改进的公式I的elvitegravir生产方法，该方法正在临床评估用于治疗HIV感染。公式I的elvitegravir是通过公式II的中间体生产的，该中间体的制备也是本解决方案的目标。
• Methods of synthesizing 3-amino-1,2-4-benzotriazines
  申请人：Moskalev V. Nikolai

  公开号：US20060142569A1

  公开（公告）日：2006-06-29

  An improved method of producing 3-amino-1,2,4-benzotriazines using nitrobenzene or a derivative thereof, a guanidine salt and a base as reactants is provided. The method is carried out at a moderate reaction temperature without producing halide wastes derived from nucleophilic substitution and acid byproducts.

  提供了一种改进的方法，用硝基苯或其衍生物、胍盐和碱作为反应物来生产3-氨基-1,2,4-苯并三嗪。该方法在适度的反应温度下进行，不会产生来自亲核取代和酸副产物的卤化物废物。
• [EN] PROCESS FOR THE PREPARATION OF ALKOXY-PHENOXY-PI PERIDINE<br/>[FR] PROCESSUS DE PRÉPARATION D'ALCOXY-PHÉNOXY-PIPÉRIDINE
  申请人：ASTRAZENECA AB

  公开号：WO2009138777A1

  公开（公告）日：2009-11-19

  A process for preparing a compound of formula (II) or a pharmaceutically acceptable salt thereof: wherein R1a is as defined in the specification, the compounds being useful in the preparation of therapeutic agents, particularly metalloproteinase inhibitors.

  一种制备式（II）化合物或其药学上可接受的盐的过程：其中R1a如规范所定义，所述化合物在制备治疗剂方面有用，特别是金属蛋白酶抑制剂。
• [EN] PROCESS FOR PREPARING SULFONYL QUINOLINES<br/>[FR] PROCÉDÉ DE PRÉPARATION DE SULFONYLE QUINOLÉINES
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2010107965A1

  公开（公告）日：2010-09-23

  Disclosed are highly convergent processes for preparing compounds of formula (I), which compounds are useful as intermediates in the preparation of potent active agents for the treatment of hepatitis C virus (HCV) infection.

  本发明揭示了制备式(I)化合物的高度收敛过程，该化合物在制备用于治疗丙型肝炎病毒（HCV）感染的有效活性剂的中间体时非常有用。