2,2,10,10-tetramethyl-3,3,9,9-tetraphenyl-4,8-dioxa-3,9-disilaundecan-6-ol | 1096143-75-7

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: 2,2,10,10-tetramethyl-3,3,9,9-tetraphenyl-4,8-dioxa-3,9-disilaundecan-6-ol
• 英文别名: 1,3-di-O-tert-butyldiphenylsilylglycerol；1,3-bis[[tert-butyl(diphenyl)silyl]oxy]propan-2-ol
• CAS: 1096143-75-7
• 化学式: C₃₅H₄₄O₃Si₂
• 分子量: 568.904
• InChiKey: SKXSFADJOJNBOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  40
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,2,10,10-tetramethyl-3,3,9,9-tetraphenyl-4,8-dioxa-3,9-disilaundecan-6-ol 在 三氯化磷 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 生成
  参考文献：
  名称：

  一种2-MCPD、D5-2-MCPD、¹³C3-2-MCPD的制备方法

  摘要：

  本申请提供一种2‑氯‑1,3‑丙二醇(2‑MCPD)、D5‑2‑氯‑1,3‑丙二醇(D5‑2‑MCPD)、13C3‑2‑氯‑1,3‑丙二醇(13C3‑2‑MCPD)及其酯类的制备方法，制备的产物作为食品加工污染物分析对照品。本申请以大宗化工产品甘油为主原料，与便宜易得的乙酰氯、苯甲酰氯、苯磺酰氯、三异丙基氯硅烷、三甲基氯硅烷、叔丁基二苯基氯硅烷辅原料等在碱性催化剂的催化下先合成两端氧被保护基R1保护的甘油酯或醚中间体A，然后经过PCl3、PCl5等氯化试剂氯化得到氯化中间体B，最后脱除保护基R1得到2‑MCPD，2‑MCPD和相应脂肪酸通过缩合剂缩合得到2‑MCPD酯。整个路线制备、分离、纯化过程简单，易得到高纯度产品，所用的试剂环境友好，总收率70‑80%，工艺成本低。

  公开号：

  CN114853564A
• 作为产物：
  描述：

  甘油 、 叔丁基二苯基氯硅烷 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 2,2,10,10-tetramethyl-3,3,9,9-tetraphenyl-4,8-dioxa-3,9-disilaundecan-6-ol
  参考文献：
  名称：

  一种2-MCPD、D5-2-MCPD、¹³C3-2-MCPD的制备方法

  摘要：

  本申请提供一种2‑氯‑1,3‑丙二醇(2‑MCPD)、D5‑2‑氯‑1,3‑丙二醇(D5‑2‑MCPD)、13C3‑2‑氯‑1,3‑丙二醇(13C3‑2‑MCPD)及其酯类的制备方法，制备的产物作为食品加工污染物分析对照品。本申请以大宗化工产品甘油为主原料，与便宜易得的乙酰氯、苯甲酰氯、苯磺酰氯、三异丙基氯硅烷、三甲基氯硅烷、叔丁基二苯基氯硅烷辅原料等在碱性催化剂的催化下先合成两端氧被保护基R1保护的甘油酯或醚中间体A，然后经过PCl3、PCl5等氯化试剂氯化得到氯化中间体B，最后脱除保护基R1得到2‑MCPD，2‑MCPD和相应脂肪酸通过缩合剂缩合得到2‑MCPD酯。整个路线制备、分离、纯化过程简单，易得到高纯度产品，所用的试剂环境友好，总收率70‑80%，工艺成本低。

  公开号：

  CN114853564A

文献信息

• The effect of electron withdrawing protecting groups at positions 4 and 6 on 1,2-cis galactosylation
  作者：Eva C. Lourenço、M. Rita Ventura

  DOI：10.1016/j.tet.2013.06.038

  日期：2013.8

  Ethyl 2,3,4-O-tribenzyl-6-O-chloroacetyl-1-D-thiogalactoside, phenyl 4,6-O-diacetyl-2,3-dibenzyl-1-D-thiogalactoside and phenyl 2,3-O-dibenzyl-4,6-O-dichloroacetyl-1-D-thiogalactoside were employed in the study of the stereoselectivity of the glycosylation reaction with several acceptors, ranging from unhindered linear primary alcohols to other sugars, using NIS/TfOH as activator. Higher alpha-selectivities were obtained in the glycosylation reactions with phenyl 2,3-O-dibenzyl-4,6-O-dichloroacetyl-1-D-thiogalactoside as the donor, showing that a stronger electron withdrawing 4-O-ester group had an influence in the anomeric selectivity favouring the formation of 1,2-cis galactosides. (C) 2013 Elsevier Ltd. All rights reserved.
• Design of new enzyme stabilizers inspired by glycosides of hyperthermophilic microorganisms
  作者：Tiago Q. Faria、Ana Mingote、Filipa Siopa、Rita Ventura、Christopher Maycock、Helena Santos

  DOI：10.1016/j.carres.2008.08.030

  日期：2008.12

  In response to stressful conditions like supra-optimal salinity in the growth medium or temperature, many microorganisms accumulate low-molecular-mass organic compounds known as compatible solutes. In contrast with mesophiles that accumulate neutral or zwitterionic compounds, the solutes of hyperthermophiles are typically negatively charged. (2R)-2-(alpha-D-Mannopyranosyl)glycerate (herein abbreviated as mannosylglycerate) is one of the most widespread solutes among thermophilic and hyperthermophilic prokaryotes. In this work, several molecules chemically related to mannosylglycerate were namely (2S)-2-(1-O-alpha-D-mannopyranosyl)propionate, 2-(1-O-alpha-D-mannopyranosyl)acetate, synthesized, (2R)-2-(1-O-alpha-D-glucopyranosyl)glycerate and 1-O-(2-glyceryl)-alpha-D-mannopyraiioside. The effectiveness of the newly synthesized compounds for the protection of model enzymes against heat-induced denaturation, aggregation and inactivation was evaluated, using differential scanning calorimetry, light scattering and measurements of residual activity. For comparison, the protection induced by natural compatible solutes, either neutral (e.g., trehalose, glycerol, ectoine) or negatively charged (di-myo-inositol-1,3 '-phosphate and diglycerol phosphate), was assessed. Phosphate, sulfate, acetate and KCl were also included in the assays to rank the solutes and new compounds in the Hofmeister series. The data demonstrate the superiority of charged organic solutes as thermo-stabilizers of enzymes and strongly support the view that the extent of protein stabilization rendered by those solutes depends clearly on the specific solute/enzyme examined. The relevance of these findings to our knowledge on the mode of action of charged solutes is discussed. (C) 2008 Elsevier Ltd. All rights reserved.