6-Nitro-1,3-benzoxathiole | 82255-59-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - Benzoxathioles
• 英文名称: 6-Nitro-1,3-benzoxathiole
• CAS: 82255-59-2
• 化学式: C₇H₅NO₃S
• 分子量: 183.188
• InChiKey: APFCLQGLISPZGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  80.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-Nitro-1,3-benzoxathiole 在 间氯过氧苯甲酸 作用下， 以 氯仿 为溶剂， 以90%的产率得到6-Nitro-1,3-benzoxathiole-S-oxide
  参考文献：
  名称：

  Cabiddu, Salvatore; Cerioni, Giovanni; Cocco, Maria Teresa, Journal of Heterocyclic Chemistry, 1982, vol. 19, p. 135 - 139

  摘要：

  DOI：
• 作为产物：
  描述：

  2-羟基苯硫酚 在 硝酸 、 caesium carbonate 、 溶剂黄146 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 6-Nitro-1,3-benzoxathiole
  参考文献：
  名称：

  Synthesis and SAR studies of bicyclic amine series GPR119 agonists

  摘要：

  We disclosed a novel series of G-protein coupled receptor 119 (GPR119) agonists based on a bicyclic amine scaffold. Through the optimization of hit compound 1, we discovered that the basic nitrogen atom of bicyclic amine played an important role in GPR119 agonist activity expression and that an indanone in various bicyclic rings was suitable in this series of compounds. The indanone derivative 2 showed the effect of plasma glucose control in oGTT and scGTT in the rodent model. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.05.117

文献信息

• CABIDDU, S.;CERIONI, G.;COCCO, M. T.;MACCIONI, A.;PLUMITALLO, A., J. HETEROCYCL. CHEM., 1982, 19, N 1, 135-139
  作者：CABIDDU, S.、CERIONI, G.、COCCO, M. T.、MACCIONI, A.、PLUMITALLO, A.

  DOI：——

  日期：——
• Synthesis and SAR studies of bicyclic amine series GPR119 agonists
  作者：Masao Sakairi、Masakazu Kogami、Masafumi Torii、Hiroyo Kataoka、Hiroki Fujieda、Mitsuhiro Makino、Daisuke Kataoka、Ryuji Okamoto、Toshiyuki Miyazawa、Morio Okabe、Megumi Inoue、Naoki Takahashi、Satoko Harada、Nobuhide Watanabe

  DOI：10.1016/j.bmcl.2012.05.117

  日期：2012.8

  We disclosed a novel series of G-protein coupled receptor 119 (GPR119) agonists based on a bicyclic amine scaffold. Through the optimization of hit compound 1, we discovered that the basic nitrogen atom of bicyclic amine played an important role in GPR119 agonist activity expression and that an indanone in various bicyclic rings was suitable in this series of compounds. The indanone derivative 2 showed the effect of plasma glucose control in oGTT and scGTT in the rodent model. (C) 2012 Elsevier Ltd. All rights reserved.
• Cabiddu, Salvatore; Cerioni, Giovanni; Cocco, Maria Teresa, Journal of Heterocyclic Chemistry, 1982, vol. 19, p. 135 - 139
  作者：Cabiddu, Salvatore、Cerioni, Giovanni、Cocco, Maria Teresa、Maccioni, Antonio、Plumitallo, Antonio

  DOI：——

  日期：——