trans-[Cu(2,2-dimethyl-1,3-propanediamine)₂Cl₂] | 77289-37-3

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 英文名称: trans-[Cu(2,2-dimethyl-1,3-propanediamine)₂Cl₂]
• 英文别名: (2,2-dimethylpropane-1,3-diamine)2Cu(II)Cl2；[CuCl2(2,2-dimethyl-1,3-propanediamine)2]；dichlorocopper;2,2-dimethylpropane-1,3-diamine
• CAS: 77289-37-3
• 化学式: C₁₀H₂₈Cl₂CuN₄
• 分子量: 338.811
• InChiKey: SPJMCIYMBNBLCO-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  1,1'-diacetyl-2,2'-biimidazole 、 trans-[Cu(2,2-dimethyl-1,3-propanediamine)₂Cl₂] 在 HCl 作用下， 以 1,4-二氧六环 、 水 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and structures of Octaaza NiII and CuII macrocyclic complexes containing biimidazole

  摘要：

  The reactions of bis-(ethylenediamine)MX2, M(en)(2)X-2, bis-(1,3-propylenediamine)MX2, M(1,3-DAP)(2)X-2, and bis-(2,2-dimethyl-1,3-propylenediamine)MX2, M(2,2-DM-1,3-DAP)(2)X-2 complexes, [M = Cu-II or Ni-II and X = Cl- or ClO4-], after adjusting the pH values to 5, with 1,1-diacetyl-2,2'-biimidazole (Ac(2)BiIm) afforded octaazamacrocyclic Cu-II complexes (1-6) and Ni-II complexes (7-12). The solid complexes were characterized by elemental analysis, molar conductivities, IR, UV-vis, EPR, NMR and atomic absorption spectra, back titration, TGA and DTA. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0277-5387(97)00183-6
• 作为产物：
  描述：

  二甲基丙二胺 、 copper dichloride 以 甲醇 为溶剂， 生成 trans-[Cu(2,2-dimethyl-1,3-propanediamine)₂Cl₂]
  参考文献：
  名称：

  Battaglia, Luigi Pietro; Bonamartini Corradi, Anna; Marcotrigiano, Giuseppe, Journal of the Chemical Society, Dalton Transactions

  摘要：

  DOI：

文献信息

• Copper(II) complexes with different diamines as inhibitors of bacterial quorum sensing activity
  作者：Ivana Stanojevic、Ivana Aleksic、Nenad Draskovic、Biljana Glisic、Sandra Vojnovic、Jasmina Nikodinovic-Runic

  DOI：10.2298/jsc170706087s

  日期：——

  Three copper(II) complexes, trans-[Cu(1,3-pd)2Cl2]?H2O (Cu1; 1,3-pd is 1,3-propanediamine), trans-[Cu(2,2-diMe-1,3-pd)2Cl2] (Cu2; 2,2-diMe- -1,3-pd is 2,2-dimethyl-1,3-propanediamine) and trans-[Cu(1,3-pnd)2Cl2]?H2O (Cu3; 1,3-pnd is (?)-1,3-pentanediamine), were synthesized and structurally characterized by elemental microanalyses, IR, electronic absorption and reflectance spectroscopy and molar conductivity measurements. The antimicrobial efficiency of the complexes against four clinically relevant microorganisms and their antiproliferative effect on the normal human lung fibroblast cell line MRC-5 were evaluated. Since in many bacteria, pathogenicity is regulated by an intercellular communication process called quorum sensing (QS), the effect of the copper(II) complexes Cu1?3 on bacterial QS was examined. The obtained results showed that these complexes inhibited violacein production in Chromobacterium violaceum CV026, indicating their anti-QS activity via the homoserine lactone (HSL) pathway. Two biosensor strains were used to determine which pathway, C4-HSL (N-butanoylhomoserine lactone) or 3OC12-HSL (N-(3-oxododecanoyl)homoserine lactone), was affected by the copper(II) complexes. The biological activities of the copper(II) complexes were compared with those for the nickel(II) complexes of the general formula trans- -[Ni(L)2(H2O)2]Cl2 (L = 1,3-pd, 2,2-diMe-1,3-pd and 1,3-pnd).

  合成了三种铜（II）配合物，即反式-[Cu(1,3-pd)2Cl2]?H2O（Cu1；1,3-pd 为 1,3-丙二胺）、反式-[Cu(2,2-diMe-1,3-pd)2Cl2]（Cu2；2,2-diMe-1,3-pd 为 2,2-二甲基-1,3-丙二胺）和反式-[Cu(1,3-pnd)2Cl2]? (Cu3; 1,3-pnd is (?)-1,3-pentanediamine) 合成，并通过元素显微分析、红外光谱、电子吸收光谱和反射光谱以及摩尔电导率测量对其结构进行了表征。评估了复合物对四种临床相关微生物的抗菌效率，以及对正常人肺成纤维细胞系 MRC-5 的抗增殖作用。由于许多细菌的致病性受一种称为 "法定人数感应"（QS）的细胞间通讯过程的调控，因此研究人员考察了铜（II）复合物 Cu1?3 对细菌 QS 的影响。结果表明，这些络合物抑制了 Chromobacterium violaceum CV026 的维拉丝素产生，表明它们通过均丝氨酸内酯（HSL）途径具有抗 QS 活性。利用两种生物传感器菌株来确定铜（II）复合物对 C4-HSL（N-丁酰基高丝氨酸内酯）或 3OC12-HSL （N-(3-氧代十二碳酰基)高丝氨酸内酯）途径的影响。铜（II）络合物的生物活性与通式为反式-[Ni(L)2( )2]Cl2（L = 1,3-pd、2,2-diMe-1,3-pd 和 1,3-pnd）的镍（II）络合物的生物活性进行了比较。
• Aluminum, gallium and copper complexes of 2,2-dimethyl-1,3-propanediamine
  作者：Stephen J. Obrey、Simon G. Bott、Andrew R. Barron

  DOI：10.1016/s0022-328x(01)01151-2

  日期：2002.2

  Reaction of M('Bu)(3) (M = Al. Ga) with 2,2-dimethyl-1,3-propanediamine (dmpa-H-4) yields the thermally stable Lewis acid-base complexes ('Bu)(3)M(dmpa-H-4), M = Al (1) and Ga (2), respectively. The reaction of 2 with Ga('Bu)(3) yields the formation of [('Bu)(3)Ga](2)(dmpa-H-4) (3). In contrast, reaction of dmpa-H-4 with AlMe3 yields the tri-aluminum compounds [Al3Me5(dmpa-H-2)(2)] (4). Reaction of dmpa-H-4 With CuCl2 in MeOH-THF yields the neutral complex, [Cu(dmpa-H-4)(2)Cl-2] (5), While the reaction in the presence of NaBPh4 and MeCN yields the ionic complex [Cu(dmpa)(2)(MeCN)(2)][BPh4](2) (6). Compound 6 may also be formed directly from compound 5. The molecular structures of compounds 2-6 have been determined by X-ray crystallography. (C) 2002 Elsevier Science B.V. All rights reserved.