diisopropyl <(75)Se>diselenide | 86508-35-2

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 英文名称: diisopropyl <(75)Se>diselenide
• CAS: 86508-35-2
• 化学式: C₆H₁₄Se₂
• 分子量: 236.177
• InChiKey: MZILKVSMAWURCJ-ROOYLTQSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.97
• 重原子数：
  8.0
• 可旋转键数：
  3.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  0.0

反应信息

• 作为反应物：
  描述：

  diisopropyl <(75)Se>diselenide 在 sodium tetrahydroborate 作用下， 以 甲醇 、 苯 为溶剂， 生成 sodium isopropyl<(75)Se>selenol
  参考文献：
  名称：

  Synthesis and evaluation of 24-(isopropyl[75Se]seleno)chol-5-en-3.beta.-ol

  摘要：

  Selenium-75-labeled 24-(isopropylseleno)chol-5-en-3 beta-ol (4) has been prepared by reaction of sodium isopropyl-[75Se]selenol [( 75Se]2) with 3 beta-acetoxy-24-bromochol-5-ene (3). This new 75Se-labeled adrenal imaging agent shows pronounced adrenal uptake in rats. The concentration of radioactivity in rat adrenals increased steadily from 1 to 24 h after injection and then decreased slowly over the 21-day period. After 3 days the adrenal/blood and adrenal/liver ratios were 85:1 and 32:1, respectively, which are sufficient for adrenal imaging by single photon techniques. After 6 h the adrenal/blood ratio was 17:1 and the adrenal/liver ratio was 7:1. We propose that these ratios are sufficiently high for positron emission tomography of the adrenals. The absorbed radiation dose values to human organs have been estimated for the 75Se- and 73Se-labeled agent.

  DOI：

  10.1021/jm00364a035
• 作为产物：
  描述：

  2-碘代丙烷 在 selenium-75 、 氨 、 sodium 作用下， 反应 2.0h， 以33%的产率得到diisopropyl <(75)Se>diselenide
  参考文献：
  名称：

  Synthesis and evaluation of 24-(isopropyl[75Se]seleno)chol-5-en-3.beta.-ol

  摘要：

  Selenium-75-labeled 24-(isopropylseleno)chol-5-en-3 beta-ol (4) has been prepared by reaction of sodium isopropyl-[75Se]selenol [( 75Se]2) with 3 beta-acetoxy-24-bromochol-5-ene (3). This new 75Se-labeled adrenal imaging agent shows pronounced adrenal uptake in rats. The concentration of radioactivity in rat adrenals increased steadily from 1 to 24 h after injection and then decreased slowly over the 21-day period. After 3 days the adrenal/blood and adrenal/liver ratios were 85:1 and 32:1, respectively, which are sufficient for adrenal imaging by single photon techniques. After 6 h the adrenal/blood ratio was 17:1 and the adrenal/liver ratio was 7:1. We propose that these ratios are sufficiently high for positron emission tomography of the adrenals. The absorbed radiation dose values to human organs have been estimated for the 75Se- and 73Se-labeled agent.

  DOI：

  10.1021/jm00364a035