N-(9-oxo-9H-thioxanthene-2-yl)methyl-N,N-dimethyl-N-(2-hydroxyethyl)ammonium bromide | 1048693-20-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫色烯
• 英文名称: N-(9-oxo-9H-thioxanthene-2-yl)methyl-N,N-dimethyl-N-(2-hydroxyethyl)ammonium bromide
• 英文别名: 2-hydroxy-N,N-dimethyl-N-[(9-oxo-9H-thioxanthen-2-yl)methyl]-ethanaminium bromide；2-Hydroxyethyl-dimethyl-[(9-oxothioxanthen-2-yl)methyl]azanium;bromide
• CAS: 1048693-20-4
• 化学式: Br*C₁₈H₂₀NO₂S
• 分子量: 394.332
• InChiKey: STSYJEKNQIZBGE-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.01
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  62.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• DRUG COMBINATIONS TO TREAT DRUG RESISTANT TUMORS
  申请人：Kiss Zoltan

  公开号：US20080207738A1

  公开（公告）日：2008-08-28

  Embodiments of the invention provide a method and composition for treating or reducing multiple drug resistance in cancers. Embodiments of the invention also provide for a xanthene compound to inhibit multidrug resistance protein 1.

  本发明实施例提供了一种治疗或减少癌症中多药耐药的方法和组合物。本发明实施例还提供了一种黄色素化合物，用于抑制多药耐药蛋白1。
• COMPOSITIONS AND METHODS TO CONTROL ABNORMAL CELL GROWTH
  申请人：Kiss Zoltan

  公开号：US20100022617A1

  公开（公告）日：2010-01-28

  A class of compounds commonly containing a trialkylammonium group have been synthesized and characterized as anticancer compounds. A representative of this class, N,N-diethyl-N-methyl-2-[(9-oxo-9H-thioxanthen-2-yl)methoxy]ethanaminium iodide (CCDTHT) was shown in various tumor models to decrease tumor volume, enhance the effects of other chemotherapeutic agents including cisplatin, reduce chemotherapy-induced loss of body weight, and increase survival of animals co-treated with toxic amounts of cisplatin. CCDTHT had even greater effects on tumor volume, body weight, and survival when administered to animals together with the human protein placental alkaline phosphatase. These trialkylammonium group-containing compounds and alkaline phosphatases, particularly in combination with each other and other therapies, may be used to treat cancer and other cell proliferative diseases.

  一类含有三烷基铵基团的化合物已被合成和表征为抗癌化合物。该类化合物的代表物N,N-二乙基-N-甲基-2-[(9-氧代-9H-噻吩并[2,3-f]苯并-2-基)甲氧基]乙胺碘化物（CCDTHT）在各种肿瘤模型中表现出降低肿瘤体积、增强其他化疗药物（包括顺铂）的作用、减少化疗所致体重丢失和增加与顺铂一起治疗的动物的生存率等效应。当与人类蛋白质胎盘碱性磷酸酶一起给动物治疗时，CCDTHT对肿瘤体积、体重和生存率的影响更大。这些含有三烷基铵基团和碱性磷酸酶的化合物，特别是它们相互之间和与其他治疗方法相结合，可能被用于治疗癌症和其他细胞增殖性疾病。
• COMPOUNDS AND COMPOSITIONS TO CONTROL ABNORMAL CELL GROWTH
  申请人：Kiss Zoltan

  公开号：US20070060634A1

  公开（公告）日：2007-03-15

  A class of compounds commonly containing a trialkylammonium group have been synthesized and characterized as anticancer compounds. A representative of this class, N,N-diethyl-N-methyl-2-[(9-oxo-9H-thioxanthen-2-yl)methoxy]ethanaminium iodide (CCDTHT) was shown in various tumor models to decrease tumor volume, enhance the effects of other chemotherapeutic agents including cisplatin, reduce chemotherapy-induced loss of body weight, and increase survival of animals co-treated with toxic amounts of cisplatin. CCDTHT had even greater effects on tumor volume, body weight, and survival when administered to animals together with the human protein placental alkaline phosphatase. These trialkylammonium group-containing compounds and alkaline phosphatases, particularly in combination with each other and other therapies, may be used to treat cancer and other cell proliferative diseases.

  一类常见的化合物，通常含有三烷基铵基团，已被合成并作为抗癌化合物进行了表征。该类化合物的代表物是N，N-二乙基-N-甲基-2-[(9-氧代-9H-噻二苯并-2-基)甲氧基]乙胺碘化物（CCDTHT），在各种肿瘤模型中显示出降低肿瘤体积、增强其他化疗药物（包括顺铂）的效果、减少化疗引起的体重损失以及增加共同接受有毒量顺铂的动物的生存率。当与人类蛋白质胎盘碱性磷酸酶一起给动物施用时，CCDTHT对肿瘤体积、体重和生存率的影响更大。这些含有三烷基铵基团和碱性磷酸酶的化合物，特别是与彼此和其他治疗方法结合使用时，可用于治疗癌症和其他细胞增殖性疾病。
• PHOTOSENSITIVE COMPOSITION
  申请人：Motofuji Shihei

  公开号：US20120142806A1

  公开（公告）日：2012-06-07

  Provided is a photosensitive composition which can be cured with low energy consumption, even when a substance (such as a colorant) that attenuates or shades an illumination light is contained in a high concentration or even when the photosensitive composition is in the form of a thick film. Specifically provided is a photosensitive composition which comprises the following four components: (1) a radical initiator (A); (2) an acid generator (B) or a base generator (C); (3) a polymerizable substance (D); and (4) a colorant (E), a metal oxide powder (F), or a metal powder (G). Further, the photosensitive composition is characterized in that the radical initiator (A), the acid generator (B), and/or the base generator (C) generates an active species (H) through irradiation with an active ray of light; the active species (H) reacts the radical initiator (A), the acid generator (B), or the base generator (C) to form another species (I); and thus the polymerization of the polymerizable substance (D) by means of the active species (I) proceeds, said active species (H) or (I) being an acid or a base.

  提供的是一种光敏组合物，即使含有高浓度的能够衰减或遮蔽照明光的物质（如颜料），或者即使光敏组合物呈现为厚膜形式，也能够以低能耗进行固化。具体而言，提供的光敏组合物包括以下四个组分：（1）自由基引发剂（A）；（2）酸发生剂（B）或碱发生剂（C）；（3）可聚合物质（D）；以及（4）颜料（E）、金属氧化物粉末（F）或金属粉末（G）。此外，光敏组合物的特点在于，自由基引发剂（A）、酸发生剂（B）和/或碱发生剂（C）通过活性光线的照射生成活性物质（H）；活性物质（H）与自由基引发剂（A）、酸发生剂（B）或碱发生剂（C）反应形成另一种物质（I）；因此，通过活性物质（I）对可聚合物质（D）进行聚合，所述活性物质（H）或（I）为酸或碱。
• PHOTOSENSITIVE COMPOSITION. CURED ARTICLE, AND METHOD FOR PRODUCING ACTINICALLY CURED ARTICLE
  申请人：Motofuji Shihei

  公开号：US20140045966A1

  公开（公告）日：2014-02-13

  The photosensitive composition of the present invention includes: (1) a radical initiator (A); (2) an acid generator (B) and/or a base generator (C); and (3) a polymerizable substance (D), wherein at least one of the radical initiator (A), the acid generator (B) and the base generator (C) are to generate an active species (H) on exposure to active rays, the active species (H) reacting with the radical initiator (A), the acid generator (B) or the base generator (C) to generate another active species (I), the active species (I) initiating polymerization of the polymerizable substance (D), the active species (H) or (I) is an acid or a base, and the photosensitive composition contains substantially no colorants, metal oxide powder, or metallic powder.

  本发明的光敏组合物包括：(1)自由基引发剂(A)；(2)酸发生剂(B)和/或碱发生剂(C)；以及(3)可聚合物质(D)，其中至少一个自由基引发剂(A)、酸发生剂(B)和碱发生剂(C)被用于在暴露于活性射线时产生活性物质(H)，活性物质(H)与自由基引发剂(A)、酸发生剂(B)或碱发生剂(C)反应，产生另一个活性物质(I)，活性物质(I)引发可聚合物质(D)的聚合，活性物质(H)或(I)是酸或碱，且光敏组合物不含有色剂、金属氧化物粉末或金属粉末。