2-Hydroxy-1-(hydroxymethyl)ethyl icosanoate | 55334-78-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 内源性大麻素
• 英文名称: 2-Hydroxy-1-(hydroxymethyl)ethyl icosanoate
• 英文别名: 1,3-dihydroxypropan-2-yl icosanoate
• CAS: 55334-78-6
• 化学式: C₂₃H₄₆O₄
• 分子量: 386.6
• InChiKey: KECCPKLXQUOWMI-UHFFFAOYSA-N

物化性质

• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  8.3
• 重原子数：
  27
• 可旋转键数：
  22
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• MONOACYLGLYCEROL LIPASE INHIBITORS
  申请人：Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis

  公开号：EP3875452A1

  公开（公告）日：2021-09-08

  Provided are compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof: Also provided are compositions comprising compounds of formula (I). The compounds and compositions are also provided for use as medicaments, for example as medicaments useful in the treatment of a condition modulated by monoacylglycerol lipase (MAGL). Also provided are the use of compounds and compositions for the inhibition of monoacylglycerol lipase (MAGL).

  提供的是式(I)的化合物，或其药学上可接受的盐或溶剂： 还提供了包含式(I)化合物的组合物。这些化合物和组合物还可用作药物，例如用于治疗由单酰基甘油脂酶（MAGL）调节的疾病的药物。还提供了利用这些化合物和组合物来抑制单酰基甘油脂酶（MAGL）的用途。
• Method and Kit for Regulation of Microvascular Tone
  申请人：Moore, II Bob M.

  公开号：US20090099254A1

  公开（公告）日：2009-04-16

  Methods and kits for regulating arterial microvascular tone in which a composition comprising a COX-2 inhibitor and a cannabinoid receptor agonist are administered to a subject.
• PERSONAL VAPORIZER LIQUID FOR EMULSIFYING OIL-SOLUBLE COMPOUNDS AND RESINS
  申请人：Verso PV, LLC

  公开号：US20150083146A1

  公开（公告）日：2015-03-26

  The present technology relates to liquid compositions for use in a personal vaporizer. More particularly, the present technology relates to liquid compositions for forming stable emulsions of oil-soluble compounds and resins, and to methods of administering vaporized oil-soluble compounds and resins to a subject by inhalation.
• USE OF CANNABIS TO TREAT FIBROMYALGIA, METHODS AND COMPOSITIONS THEREOF
  申请人：ONE WORLD CANNABIS LTD

  公开号：US20200129471A1

  公开（公告）日：2020-04-30

  The present invention discloses a composition comprising cannabis natural extract, or synthetic cannabinoids, for use in treating a subject suffering from fibromyalgia. The present invention further discloses methods and uses of the aforementioned composition.
• US4395509A
  申请人：——

  公开号：US4395509A

  公开（公告）日：1983-07-26