Atropin-methobromid | 4662-16-2

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 托烷生物碱
• 英文名称: Atropin-methobromid
• 英文别名: Atropine methyl bromide；(8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl) 3-hydroxy-2-phenylpropanoate;bromide
• CAS: 4662-16-2；150521-11-2；150521-13-4
• 化学式: Br*C₁₈H₂₆NO₃
• 分子量: 384.313
• InChiKey: XMLNCADGRIEXPK-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.92
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Quickly disintegrable compression-molded materials and process for producing the same
  申请人：DAIICHI PHARMACEUTICAL CO., LTD.

  公开号：EP1380308A1

  公开（公告）日：2004-01-14

  A quickly disintegratable compression-molded material characterized by comprising cellulose and erythritol.

  一种可快速分解的压缩成型材料，其特征在于由纤维素和赤藓糖醇组成。
• Combinatorial therapy with an acetylcholinesterase inhibitor and (3aR) 1,3a,8 trimethyl 1,2,3,3a,8,8a hexahydropyrrolo[2,3 b]indol 5 yl phenylcarbamate
  申请人：Axonyx, Inc.

  公开号：EP1576955A1

  公开（公告）日：2005-09-21

  The present invention relates to an improved method of treating, reducing or delaying cognitive impairments associated with the β-amyloid peptide, either in combination with treatment by cholinomimetic replacement therapy or as a prophylactic treatment.

  本发明涉及一种治疗、减轻或延缓与β-淀粉样肽相关的认知障碍的改进方法，该方法可与胆碱能替代疗法结合使用，也可作为一种预防性治疗方法。
• Metered dose dispensers with porous body
  申请人：Jinks Philip A.

  公开号：US10335562B2

  公开（公告）日：2019-07-02

  A pressurized metered dose dispenser (100) for dispensing an aerosol formulation comprising particles of a medicament suspended in liquefied propellant, optionally in combination with one or more excipients, the dispenser comprising an aerosol container (1) equipped with a metered dose valve (10), where a formulation chamber is defined in part by the internal walls of the container, and wherein the dispenser further comprises a porous, fluid permeable, particulate semi-permeable body (40) located within the formulation chamber adjacent to the metered dose valve.

  一种加压计量剂量分配器（100），用于分配气溶胶制剂，该制剂包括悬浮在液化推进剂中的药物颗粒，可选择与一种或多种赋形剂结合使用，分配器包括装有计量剂量阀（10）的气溶胶容器（1），其中制剂室部分由容器的内壁限定，分配器还包括位于制剂室内与计量剂量阀相邻的多孔、可渗透流体的微粒半透体（40）。
• Transdermal therapeutic system for highly dispersed silicon dioxide
  申请人：——

  公开号：US20040086552A1

  公开（公告）日：2004-05-06

  The invention relates to a transdermal therapeutic system comprising a surface layer which is impervious with respect to an active ingredient; a self-adherent matrix layer or a plurality of matrix layers, wherein the exposed matrix layer is, at least self-adherent when the system is applied. Said system also comrises a pull-off protective coating, whereby the matrix layer(s) contains one or more active ingredients and/or one or more biologically active substances and highly dispersed silicon dioxide. Said system contains silicon dioxide in order to increase skin permeation.

  本发明涉及一种透皮治疗系统，该系统包括不透活性成分的表层；自粘基质层或多个基质层，其中暴露的基质层在使用该系统时至少是自粘的。所述系统还包括拉脱保护层，其中基质层含有一种或多种活性成分和/或一种或多种生物活性物质以及高度分散的二氧化硅。所述系统含有二氧化硅是为了增加皮肤渗透性。
• Combinatorial therapy with an acetylcholinesterase inhibitor and (3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3,-b]indol-5-yl phenylcarbamate
  申请人：Bruinsma B. Gosse

  公开号：US20050182044A1

  公开（公告）日：2005-08-18

  The present invention relates to an improved method of treating, reducing or delaying cognitive impairments associated with the β-amyloid peptide, either in combination with treatment by cholinomimetic replacement therapy or as a prophylactic treatment.

  本发明涉及一种治疗、减轻或延缓与β-淀粉样肽相关的认知障碍的改进方法，该方法可以与胆碱能替代疗法相结合，也可以作为预防性治疗。

表征谱图