N-methyl-N-trimethylsilylcarbamic acid trimethylsilyl ester | 51041-97-5

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: N-methyl-N-trimethylsilylcarbamic acid trimethylsilyl ester
• 英文别名: trimethylsilyl N-methyl-N-trimethylsilyl carbamate；trimethylsilyl N-methyl-N-trimethylsilylcarbamate；trimethylsilyl N-trimethylsilyl-N-methylcarbamate；N,O-bis(trimethylsilyl)-N-methylcarbamate；Trimethylsilyl methyl(trimethylsilyl)carbamate
• CAS: 51041-97-5
• 化学式: C₈H₂₁NO₂Si₂
• 分子量: 219.431
• InChiKey: MVGJETJSISRUMH-UHFFFAOYSA-N

物化性质

• 沸点：
  44-45 °C(Press: 1.5 Torr)
• 密度：
  0.903±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.72
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-methyl-N-trimethylsilylcarbamic acid trimethylsilyl ester 在 光气 作用下， 10.0~50.0 ℃ 、101.33 kPa 条件下， 反应 1.0h， 以99%的产率得到异氰酸甲酯
  参考文献：
  名称：

  使用邻甲硅烷基乙烷合成异氰酸酯的新方面

  摘要：

  O-甲硅烷基氨基甲酸酯中氮原子上的甲硅烷基极大地影响了热解过程，并使得人们可以简化异氰酸甲酯和三甲基甲硅烷基异氰酸酯的合成。

  DOI：

  10.1016/j.mencom.2017.01.033
• 作为产物：
  描述：

  trimethylsilyl N-methylcarbamate 生成 N-methyl-N-trimethylsilylcarbamic acid trimethylsilyl ester
  参考文献：
  名称：

  KNAUSZ, D.;MESZTICZKY, A.;SZAKACS, L.;CSAKVARI, B.;UJSZASZY, K., J. ORGANOMET. CHEM., 1983, 256, N 1, 11-21

  摘要：

  DOI：

文献信息

• Trimethylsilylated N- alkyl-substituted carbamates I.preparation and some reactions
  作者：Dezsö Knausz、Aranka Meszticzky、L′aszl′o Szak′acs、B′ela Cs′akv′ari、K′alm′an Ujsz′aszy

  DOI：10.1016/s0022-328x(00)99291-x

  日期：1983.11

  ammonium carbamates with trimethylchlorosilane. Trimethylsilyl NN-dimethylcarbamate can be used for silylation of alcohols,phenols, and carboxylic acids. The silycarbamates react with carboxylic acid halides to give the corresponding acide amides. The reaction of trimethylsilyl carbamates with carboxylic anhydrides give the corresponding silyl carboxylate and acid amide, while the reaction with dicarboxylic

  三甲基甲硅烷Ñ -monoalkyl-和Ñ，Ñ二烷基-氨基甲酸酯已在85-95％的收率由相应的氨基甲酸铵与三甲基氯硅烷的甲硅烷基化制备。三甲基甲硅烷基N N-二甲基氨基甲酸酯可用于醇，酚和羧酸的甲硅烷基化。甲硅烷基氨基甲酸酯与羧酸卤化物反应，得到相应的酸酰胺。氨基甲酸三甲基甲硅烷基酯与羧酸酐的反应生成相应的甲硅烷基羧酸酯和酰胺，而与二羧酸酐的反应生成相应的二羧酸的三甲基甲硅烷基单酰胺，即Me 3 SiO 2 -CCONR 1 R2。
• Organosilicon synthesis of isocyanates: II. Synthesis of aliphatic, carbocyclic, and fatty-aromatic isocyanates
  作者：A. V. Lebedev、A. B. Lebedeva、V. D. Sheludyakov、S. N. Ovcharuk、E. A. Kovaleva、O. L. Ustinova

  DOI：10.1134/s1070363206030182

  日期：2006.3

  Silylation of a series of aliphatic, carbocyclic, and fatty-aromatic amines gave the corresponding silyl derivatives whose yield depended on the electronic and steric structure of the substrate and the nature of the silylating agent. The yield of isocyanates obtained by phosgenation of the silyl derivatives under mild conditions decreased in going from aliphatic amines to benzylamines and rose as the length of the alkyl chain in fatty-aromatic amines extended. The most convenient procedure for the synthesis of low-boiling alkyl isocyanates was found to be based on the transformation of amines or ammonium salts into silyl or silyl silyl-carabamates. followed by pyrolysis of the latter in the presence of trichloro(phenyl)silane.
• The reaction of chloromethylsilanes with amines, hexamethyldisilazanes, and silylcarhamates
  作者：A. D. Kirilin、N. B. Sokova、E. A. Chernyshev

  DOI：10.1007/bf00703492

  日期：1994.10

  The reactions of chloromethylsilanes with amines, hexamethyldisilazane, and silylcarbamates were studied. The dependence of the composition and structure of the resulting products on the nature of the reagents used and reaction conditions was determined. A scheme for the synthesis of 4,9-diaza-2,7-dioxa-1,6-disilacyclodecane-3,8-dione derivatives was suggested.
• Kozyukov, V. P.; Kozyukov, Vik. P.; Kisin, A. V., Journal of general chemistry of the USSR, 1984, vol. 54, # 3, p. 562 - 566
  作者：Kozyukov, V. P.、Kozyukov, Vik. P.、Kisin, A. V.、Nikishina, I. S.、Bochkarev, V. N.、et al.

  DOI：——

  日期：——
• Sheludyakov, V. D.; Shukyurov, A. Kh.; Kirilina, N. I., Journal of general chemistry of the USSR, 1988, vol. 58, # 1, p. 81 - 87
  作者：Sheludyakov, V. D.、Shukyurov, A. Kh.、Kirilina, N. I.、Sokova, N. B.、Kirilin, A. D.

  DOI：——

  日期：——