diallylphosphine | 25004-80-2

• 分子结构分类: 有机化合物 - 有机磷化合物
• 英文名称: diallylphosphine
• 英文别名: bis(prop-2-enyl)phosphane
• CAS: 25004-80-2
• 化学式: C₆H₁₁P
• 分子量: 114.127
• InChiKey: PQGAOGLZZIZHTI-UHFFFAOYSA-N

物化性质

• 沸点：
  143.1±29.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  7
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  diallylphosphine oxide 在 四氯化碳 作用下， 以91%的产率得到diallylphosphine
  参考文献：
  名称：

  A Convenient and Facile Synthesis of Dialkylphosphines

  摘要：

  一系列简单的二烷基膦2通过二烷基膦氧化物1的热歧化作用制备，该反应由R2P(O)Cl/R2PCl体系引发，后者是在1中加入少量四氯化碳的情况下原位生成的。

  DOI：

  10.1055/s-1987-28000

文献信息

• Novel catalysts useful for catalyzing the coupling of arylhalides with arylboronic acids
  申请人：Ionkin Sergey Alex

  公开号：US20060281923A1

  公开（公告）日：2006-12-14

  The present invention relates to a new method of cross-coupling aryl moieties comprising reacting an arylhalide with an arylboronic acid in the presence of a palladium compound and a compound comprising a di-alkylphosphine moiety.

  本发明涉及一种新的芳基偶联方法，包括在钯化合物和含有二烷基膦基团的化合物存在下，将芳基卤化物与芳基硼酸反应。
• PHOSPHORUS-CONTAINING CATALYSTS
  申请人：AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

  公开号：US20160207034A1

  公开（公告）日：2016-07-21

  The invention provides compounds of general structure I: (Ar 1 —Ar 2 —Ar 3 -E-P(=D)R 2 -) n M m X n L n ″. In this structure: •Ar 1 , Ar 2 and Ar 3 are aromatic groups wherein: —Ar 1 and Ar 3 are in a 1,3 relationship on Ar 2 , —each of Ar 1 , Ar 2 and Ar 3 optionally comprises one or more ring substituents of formula YR′ r wherein each Y independently is absent or is O, S, B, N or Si and each R′ is independently H, halogen, alkyl, cycloalkyl, aryl or heteroaryl and r is 1, 2 or 3, where r is 1 if Y is absent or is O or S, 2 if Y is B or N and 3 if Y is Si, —Ar 1 , Ar 2 and Ar 3 are each independently carbocyclic or heterocyclic and each is independently monocyclic, bicyclic or polycyclic and each ring of each of Ar 1 , Ar 2 and Ar 3 independently has 5, 6 or 7 ring atoms; •E is absent or is selected from the group consisting of O, S, NR″, SiR″ 2 , AsR″ 2 and CR″ 2 ; •M is a complexing metal; •X is selected from the group consisting of H, F, Br, CI, I, OTf, dba (dibenzylidene acetone), OC(═O)CF 3 and OAc; •L is selected from the group consisting of PR″ 2 , NR″ 2 , OR″, SR″, SiR″ 3 , AsR″ 3 , alkene, alkyne, aryl and heteroaryl, each of said alkene, alkyne, aryl and heteroaryl being optionally substituted, for example with one or more halogens and/or with one or more R groups as defined herein; •each R is independently alkyl, cycloalkyl, heterocyclyl, heterocycloalkyl, aryl or -, heteroaryl; •D is absent or is ═S or —O or —Z-linker-Z—, where each Z independently is O or NH or N-alkyl and linker is an alkyl chain of 2-5 carbon atoms in length; •each R″ is independently H, alkyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl, each other than H being optionally substituted, or R″ 2 is —Z-linker-Z— as defined above; and •m is 0 or 1 or 2; wherein if m is 0, n is 1, n′ and n″ are 0 and -- is absent; and if m is 1 or 2, n is 1 or 2 and n′ and n″ are integers such that the coordination sphere of M is filled, and D is absent.

  该发明提供了一般结构I的化合物：（Ar1—Ar2—Ar3-E-P（=D）R2-）nMmXnLn″。在这个结构中： •Ar1，Ar2和Ar3是芳香族基团，其中：—Ar1和Ar3在Ar2上呈1,3关系，—Ar1，Ar2和Ar3中的每一个可选地包括一个或多个环取代基，其化学式为YR′r，其中每个Y独立地不存在或为O、S、B、N或Si，每个R′独立地为H、卤素、烷基、环烷基、芳基或杂芳基，r为1、2或3，其中如果Y不存在或为O或S，则r为1，如果Y为B或N，则r为2，如果Y为Si，则r为3，—Ar1，Ar2和Ar3分别独立地为碳环或杂环，每个分别独立地为单环、双环或多环，每个Ar1，Ar2和Ar3的每个环独立地具有5、6或7个环原子； •E不存在或从O、S、NR″、SiR″2、AsR″2和CR″2组成的群体中选择； •M是络合金属； •X从H、F、Br、Cl、I、OTf、dba（双苯亚乙酮）、OC（═O）CF3和OAc组成的群体中选择； •L从PR″2、NR″2、OR″、SR″、SiR″3、AsR″3、烯烃、炔烃、芳基和杂芳基组成的群体中选择，所述的每个烯烃、炔烃、芳基和杂芳基可选地被取代，例如用一个或多个卤素和/或如本文所定义的一个或多个R基取代； •每个R独立地为烷基、环烷基、杂环烷基、杂环烷基、芳基或-、杂芳基； •D不存在或为═S或—O或—Z-连接-Z—，其中每个Z独立地为O或NH或N-烷基，连接体为长度为2-5个碳原子的烷基链； •每个R″独立地为H、烷基、环烷基、杂环烷基、芳基或杂芳基，除H外的每个均可选地被取代，或R″2为—Z-连接-Z—如上所定义；和 •m为0或1或2；其中如果m为0，n为1，n′和n″为0且--不存在；如果m为1或2，n为1或2，n′和n″为整数，使得M的配位球填满，并且D不存在。
• METHOD FOR PREPARING A SULFONIMIDE COMPOUND AND SALTS THEREOF
  申请人：RHODIA OPERATIONS

  公开号：US20150203449A1

  公开（公告）日：2015-07-23

  The present invention relates to a method for preparing an aqueous sulfonimide compound of the formula (Rf 1 —SO 2 ) (Rf 2 —SO 2 )NH, wherein Rf 1 et Rf 2 are independently selected from the group comprising: a fluorine atom and groups having 1 to 10 carbon atoms selected from the perfluoroalkyl, fluoroalkyl, fluoroalkenyl and fluoroallyl groups, from a mixture M1 including (Rf 1 —SO 2 )(Rf 2 —SO 2 )NH, Rf 1 SO 2 H and/or Rf 2 SO 2 H, Rf 1 SO 2 NH 2 and/or Rf 2 SO 2 NH 2 , characterized in that said method includes an oxidation step of said mixture M1 using an oxidizing agent in order to obtain a mixture M2 including (Rf 1 —SO 2 )(Rf 2 —SO 2 )NH, Rf 1 SO 3 H and/or Rf 2 SO 3 H, and Rf 1 SO 2 NH 2 and/or Rf 2 SO 2 NH 2 .

  本发明涉及一种制备以下公式的含硫酰亚胺化合物水溶液的方法： (Rf1—SO2)(Rf2—SO2)NH，其中Rf1和Rf2独立地选自包括氟原子和1至10个碳原子的全氟烷基、氟烷基、氟烯基和氟烯基的组中，从一个包括 (Rf1—SO2)(Rf2—SO2)NH，Rf1SO2H和/或Rf2SO2H，Rf1SO2NH2和/或Rf2SO2NH2的混合物M1中，其特征在于，所述方法包括使用氧化剂对所述混合物M1进行氧化步骤，以获得包括 (Rf1—SO2)(Rf2—SO2)NH，Rf1SO3H和/或Rf2SO3H，以及Rf1SO2NH2和/或Rf2SO2NH2的混合物M2。
• [EN] POLYDENTATE LIGANDS AND THEIR COMPLEXES FOR MOLECULAR CATALYSIS<br/>[FR] LIGANDS POLYDENTATES ET LEURS COMPLEXES POUR LA CATALYSE MOLÉCULAIRE
  申请人：LOS ALAMOS NAT SECURITY LLC

  公开号：WO2015191505A1

  公开（公告）日：2015-12-17

  The present invention relates generally to novel achiral and chiral sulfur-, nitrogen- and phosphorus-containing ligands, designated as NNS-type, P(0)NS-type, PNS-type, SNNS-type, SNNP(0)-type, or SNNP-type polydentate ligands and transition metal complexes of these ligands. The catalysts derived from these ligands and transition metal complexes may be used in a wide range of catalytic reactions, including hydrogenation and transfer hydrogenation of unsaturated organic compounds, dehydrogenation of alcohols and boranes, various dehydrogenative couplings, and other catalytic transformations.

  本发明涉及新型的无手性和手性硫、氮和磷含配体，被称为NNS型、P(0)NS型、PNS型、SNNS型、SNNP(0)型或SNNP型多齿配体以及这些配体的过渡金属配合物。从这些配体和过渡金属配合物衍生的催化剂可用于各种催化反应，包括不饱和有机化合物的加氢和转移加氢、醇和硼烷的脱氢、各种脱氢偶联反应以及其他催化转化。
• [EN] 2- ( (2, 3-DIHYDROXYPROPYL) AMINOMETHYL) CHROMANE DERIVATIVES FOR USE AS BETA-3 ADRENORECEPTOR AGONISTS IN THE TREATMENT OF UROLOGICAL AND INFLAMMATORY DISORDERS<br/>[FR] DERIVES DE 2- ( (2, 3-DIHYDROXYPROPYL) AMINOMETHYL) CHROMANE DESTINES A ETRE UTILISES EN TANT QU'AGONISTES DU RECEPTEUR ADRENERGIQUE BETA-3 DANS LE TRAITEMENT DE TROUBLES UROLOGIQUES ET INFLAMMATOIRES
  申请人：BAYER HEALTHCARE AG

  公开号：WO2005056544A1

  公开（公告）日：2005-06-23

  This invention relates to chroman derivatives of formula (I) and salts thereof which are useful as active ingredients of pharmaceutical preparations. The chroman derivatives of the present invention have an excellent activity as BETA 3 antagonists and are useful for the prophylaxis and treatment of diseases associated with BETA 3 activity, in particular for the treatment of urological disorder or disease, such as detrusor overactivity (overactive bladder), urinary incontinence, neurogenic detrusor overactivity (detrusor hyperflexia), idiopathic detrusor overactivity (detrusor instability), benign prostatic hyperplasia, and lower urinary tract symptoms; and inflammatory disorders, such as asthma and COPD.

  这项发明涉及公式（I）的类胡萝卜素衍生物及其盐，其可用作药物制剂的活性成分。本发明的类胡萝卜素衍生物作为BETA 3拮抗剂具有出色的活性，并可用于预防和治疗与BETA 3活性相关的疾病，特别是用于治疗泌尿系统紊乱或疾病，如膀胱过度活动（过度活跃膀胱）、尿失禁、神经源性膀胱过度活动（膀胱过度反射）、特发性膀胱过度活动（膀胱不稳定）、良性前列腺增生和下尿路症状；以及炎症性疾病，如哮喘和慢性阻塞性肺病（COPD）。