| 1236458-99-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 偶氮苯
• CAS: 1236458-99-3
• 化学式: C₂₀H₂₀N₄O₈
• 分子量: 444.401
• InChiKey: FAHVZBKDXQUPDE-WCWDXBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.26
• 重原子数：
  32.0
• 可旋转键数：
  12.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  175.98
• 氢给体数：
  4.0
• 氢受体数：
  8.0

反应信息

• 作为产物：
  描述：

  在 水 、 lithium hydroxide 作用下， 以 四氢呋喃 为溶剂， 反应 18.0h， 生成
  参考文献：
  名称：

  C2-Symmetric azobenzene-amino acid conjugates and their inhibition of Subtilisin Kexin Isozyme-1

  摘要：

  C-2-Symmetric azobenzene-amino acid/peptide hybrids containing stable E-azo moiety have been synthesized. Upon irradiation with long wavelength UV, these compounds isomerized to the Z-form, whose thermal reisomerization to the E isomer slowed down considerably. These compounds exhibited in vitro moderate to strong inhibition of mammalian cellular protease Subtilisin Kexin Isozyme-1, also called Site 1 Protease, which plays vital roles in cholesterol synthesis, lipid metabolism, bone formation, and viral infections. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.04.101

文献信息

• C2-Symmetric azobenzene-amino acid conjugates and their inhibition of Subtilisin Kexin Isozyme-1
  作者：Amit Basak、Debarati Mitra、Amit K. Das、Dayani Mohottalage、Ajoy Basak

  DOI：10.1016/j.bmcl.2010.04.101

  日期：2010.7

  C-2-Symmetric azobenzene-amino acid/peptide hybrids containing stable E-azo moiety have been synthesized. Upon irradiation with long wavelength UV, these compounds isomerized to the Z-form, whose thermal reisomerization to the E isomer slowed down considerably. These compounds exhibited in vitro moderate to strong inhibition of mammalian cellular protease Subtilisin Kexin Isozyme-1, also called Site 1 Protease, which plays vital roles in cholesterol synthesis, lipid metabolism, bone formation, and viral infections. (C) 2010 Elsevier Ltd. All rights reserved.