2-Chlor-4,6-bis-propylamino-s-triazin | 3071-66-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 2-Chlor-4,6-bis-propylamino-s-triazin
• 英文别名: 6-chloro-2-N,4-N-dipropyl-1,3,5-triazine-2,4-diamine
• CAS: 3071-66-7
• 化学式: C₉H₁₆ClN₅
• 分子量: 229.713
• InChiKey: WKFQDZJPQYALOP-UHFFFAOYSA-N

物化性质

• 熔点：
  210.5-212.0 °C
• 沸点：
  387.0±25.0 °C(Predicted)
• 密度：
  1.235±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  62.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-Chlor-4,6-bis-propylamino-s-triazin 以90的产率得到N-(4,6-bis-n-propylamino-[1,3,5]triazin-2-yl)-O,N-dimethyl-hydroxylamine
  参考文献：
  名称：

  [EN] NOVEL COMPOUNDS AS RESPIRATORY STIMULANTS FOR TREATMENT OF BREATHING CONTROL DISORDERS OR DISEASES
  [FR] NOUVEAUX COMPOSÉS COMME STIMULANTS RESPIRATOIRES POUR LE TRAITEMENT DE TROUBLES OU DE MALADIES DE CONTRÔLE DE LA RESPIRATION

  摘要：

  本发明涉及一种可用于治疗患有呼吸控制疾病或障碍的受试者的组合物。本发明还包括一种治疗患有呼吸系统疾病或障碍的受试者的方法，包括向受试者施用本发明的药物制剂的治疗有效量。本发明还包括一种预防或稳定受试者呼吸节律不稳定的方法，包括向受试者施用本发明的药物制剂的治疗有效量。

  公开号：

  WO2012074999A1
• 作为产物：
  描述：

  三聚氯氰 以85的产率得到2-Chlor-4,6-bis-propylamino-s-triazin
  参考文献：
  名称：

  [EN] NOVEL COMPOUNDS AS RESPIRATORY STIMULANTS FOR TREATMENT OF BREATHING CONTROL DISORDERS OR DISEASES
  [FR] NOUVEAUX COMPOSÉS COMME STIMULANTS RESPIRATOIRES POUR LE TRAITEMENT DE TROUBLES OU DE MALADIES DE CONTRÔLE DE LA RESPIRATION

  摘要：

  本发明涉及一种可用于治疗患有呼吸控制疾病或障碍的受试者的组合物。本发明还包括一种治疗患有呼吸系统疾病或障碍的受试者的方法，包括向受试者施用本发明的药物制剂的治疗有效量。本发明还包括一种预防或稳定受试者呼吸节律不稳定的方法，包括向受试者施用本发明的药物制剂的治疗有效量。

  公开号：

  WO2012074999A1

文献信息

• Controlling the distance between hydrogen-bonded chloro-s-triazine tapes: crystal engineering using N-alkyl chains and the influence of temperature
  作者：Vina R. Aldilla、Mohan Bhadbhade、Saroj Bhattacharyya、Naresh Kumar、Anne M. Rich、Christopher E. Marjo

  DOI：10.1039/c7ce01049d

  日期：——

  packing. Despite this variation, there is still a strong correlation of alkyl chain length with the inter-tape spacing in a single direction in the crystal. This correlation is strongest at ambient temperature where the longer chains are highly disordered and extended. We observe an “odd-number carbon” effect where bis-N-propyl 1b and bis-N-pentyl 1d derivatives undergo a structural phase transition with

  双-N-烷基-氯三嗪显示出形成固态的一维氢键带的强烈趋势。我们预测增加最简单的带形成分子中的烷基链长度将能够控制增加结晶态的带间间距。从双-N-乙基到双-N的一系列双-N-烷基在低温和环境温度下，使用单晶和粉末X射线衍射法合成了戊基戊基并对其结构进行了表征。在低温下，烷基链很少是线性的，而是采用各种构象来实现紧密堆积。尽管有这种变化，但在晶体中，烷基链长与单个方向上的带间间距仍然存在很强的相关性。在较长链高度无序和延伸的环境温度下，这种相关性最强。我们观察到“奇数碳”效应，其中双N-丙基1b和双N-戊基1d衍生物随温度发生结构相变。
• Novel Compounds and Compositions for Treatment of Breathing Control Disorders or Diseases
  申请人：Mannion James C.

  公开号：US20120295911A1

  公开（公告）日：2012-11-22

  The present invention includes compositions that are useful in the treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a pharmaceutical formulation of the invention. The present invention further includes a method of preventing destabilization or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a pharmaceutical formulation of the invention.

  本发明包括用于治疗需要呼吸控制疾病或障碍的受体的组合物。本发明还包括一种治疗需要呼吸系统疾病或障碍的受体的方法，包括向受体施用本发明的药物制剂的治疗有效量。本发明还包括一种预防或稳定需要呼吸节律的受体的方法，包括向受体施用本发明的药物制剂的治疗有效量。
• Novel Compounds as Respiratory Stimulants for Treatment of Breathing Control Disorders or Diseases
  申请人：Dax Scott L.

  公开号：US20120142647A1

  公开（公告）日：2012-06-07

  The present invention includes compositions that are useful in the treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a pharmaceutical formulation of the invention. The present invention further includes a method of preventing destabilization or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a pharmaceutical formulation of the invention.

  本发明包括用于治疗呼吸控制疾病或障碍的组合物，适用于需要该治疗的受试者。本发明还包括一种治疗呼吸系统疾病或障碍的方法，包括向受试者投予本发明的药物制剂的治疗有效量。本发明还包括一种预防或稳定受试者呼吸节律不稳定的方法，包括向受试者投予本发明的药物制剂的治疗有效量。
• NOVEL COMPOUNDS AND COMPOSITIONS FOR TREATMENT OF BREATHING CONTROL DISORDERS OR DISEASES
  申请人：GALLEON PHARMACEUTICALS, INC.

  公开号：US20140371224A1

  公开（公告）日：2014-12-18

  The present invention includes compounds, and compositions comprising the same, that are useful in the treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of the invention. The present invention further includes a method of preventing destabilization or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of the invention.

  本发明包括化合物及其组合物，适用于治疗需要治疗呼吸控制疾病或障碍的患者。本发明还包括一种治疗需要治疗呼吸系统疾病或障碍的患者的方法，包括向患者施用本发明中化合物的治疗有效量。本发明还包括一种预防或稳定需要稳定呼吸节律的患者的方法，包括向患者施用本发明中化合物的治疗有效量。
• Compounds and compositions for treatment of breathing control disorders or diseases
  申请人：GALLEON PHARMACEUTICALS, INC.

  公开号：US09162992B2

  公开（公告）日：2015-10-20

  The present invention includes compounds, and compositions comprising the same, that are useful in the treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of the invention. The present invention further includes a method of preventing destabilization or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of the invention.

  本发明涉及化合物和包含它们的组合物，其在治疗需要治疗呼吸控制疾病或障碍的受试者中有用。本发明还包括一种治疗需要治疗呼吸系统疾病或障碍的受试者的方法，包括向受试者施用本发明化合物的治疗有效量。本发明还包括一种预防不稳定或稳定呼吸节律的方法，包括向需要该治疗的受试者施用本发明化合物的治疗有效量。