1-(tert-butyldiphenylsiloxy)-22,22-dimethyl-19-oxo-3,6,9,12,15,17,19-heptaoxapentacos-24-ene | 678143-02-7

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: 1-(tert-butyldiphenylsiloxy)-22,22-dimethyl-19-oxo-3,6,9,12,15,17,19-heptaoxapentacos-24-ene
• 英文别名: 2-[2-[2-[2-[2-[2-[Tert-butyl(diphenyl)silyl]oxyethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 2,2-dimethylpent-4-enyl carbonate
• CAS: 678143-02-7
• 化学式: C₃₆H₅₆O₉Si
• 分子量: 660.921
• InChiKey: RCRCKJCJBIXRGM-UHFFFAOYSA-N

物化性质

• 沸点：
  641.1±55.0 °C(Predicted)
• 密度：
  1.07±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  46
• 可旋转键数：
  28
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  90.9
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  2,2-dimethylpent-4-en-1-ol 在 吡啶 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 24.0h， 生成 1-(tert-butyldiphenylsiloxy)-22,22-dimethyl-19-oxo-3,6,9,12,15,17,19-heptaoxapentacos-24-ene
  参考文献：
  名称：

  Transition Metal-Catalyzed One-Pot Synthesis of Water-Soluble Dendritic Molecular Nanocarriers

  摘要：

  Here, we report the first example of transition metal-catalyzed one-pot synthesis of water-soluble dendritic molecular nanocarriers behaving like unimolecular micelles. Using the palladium-alpha-diimine chain walking catalyst, copolymerization of ethylene and comonomer 3 afforded, in one step, amphiphilic copolymer 1 having a hydrophobic core and a hydrophilic shell. A much larger amphiphilic core-shell copolymer 2 was synthesized by a two-step approach: a copolymer having many free hydroxyl groups was first prepared, which was subsequently coupled to poly(ethylene glycol) (PEG) to afford the copolymer 2. Light-scattering, fluorescence, and UV/vis spectroscopic studies with Nile Red in aqueous solution showed unimolecular micellar properties for both copolymers 1 and 2. The dye encapsulation capacity for the core-shell copolymers is nearly proportional to the molecular weight of the hydrophobic core. The unimolecular micellar properties coupled with the good water solubility and biocompatibility of the PEG moieties make these molecular nanocarriers promising candidates for many applications including drug delivery and controlled drug release.

  DOI：

  10.1021/ja039829e

文献信息

• Transition metal-catalyzed synthesis of dendritic polymers
  申请人：Guan Zhibin

  公开号：US20060063859A1

  公开（公告）日：2006-03-23

  Dendritic amphiphilic polymers are contemplated. Most preferably, such polymers will be fabricated in a single step to the final product that may further be derivatized with, among others, biological relevant molecules. In alternative aspects, precursors of such molecules are prepared in a single step, and the precursors are then reacted to the dendritic amphiphilic polymers.

  树突性两性聚合物被考虑。最好的情况是，这些聚合物将在一个步骤中制备成最终产品，该产品可以进一步与其他生物相关分子衍生化。在另一方面，这些分子的前体在一个步骤中被制备，然后这些前体被反应成树突性两性聚合物。
• Transition Metal-Catalyzed One-Pot Synthesis of Water-Soluble Dendritic Molecular Nanocarriers
  作者：Guanghui Chen、Zhibin Guan

  DOI：10.1021/ja039829e

  日期：2004.3.1

  Here, we report the first example of transition metal-catalyzed one-pot synthesis of water-soluble dendritic molecular nanocarriers behaving like unimolecular micelles. Using the palladium-alpha-diimine chain walking catalyst, copolymerization of ethylene and comonomer 3 afforded, in one step, amphiphilic copolymer 1 having a hydrophobic core and a hydrophilic shell. A much larger amphiphilic core-shell copolymer 2 was synthesized by a two-step approach: a copolymer having many free hydroxyl groups was first prepared, which was subsequently coupled to poly(ethylene glycol) (PEG) to afford the copolymer 2. Light-scattering, fluorescence, and UV/vis spectroscopic studies with Nile Red in aqueous solution showed unimolecular micellar properties for both copolymers 1 and 2. The dye encapsulation capacity for the core-shell copolymers is nearly proportional to the molecular weight of the hydrophobic core. The unimolecular micellar properties coupled with the good water solubility and biocompatibility of the PEG moieties make these molecular nanocarriers promising candidates for many applications including drug delivery and controlled drug release.