<3aS-(3aα,4E,6aα)>-5-imidazol-4-ylidene>pentanoic acid methyl ester | 151415-07-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并咪唑类化合物
• 英文名称: <3aS-(3aα,4E,6aα)>-5-imidazol-4-ylidene>pentanoic acid methyl ester
• 英文别名: methyl (5E)-5-[(3aR,6aS)-3-benzyl-2-oxo-1,3a,4,6a-tetrahydrothieno[3,4-d]imidazol-6-ylidene]pentanoate
• CAS: 151415-07-5
• 化学式: C₁₈H₂₂N₂O₃S
• 分子量: 346.45
• InChiKey: FOXMAVOLQJAGBG-QFYPQXEXSA-N

物化性质

• 沸点：
  590.8±50.0 °C(Predicted)
• 密度：
  1.278±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  83.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  <3aS-(3aα,4E,6aα)>-5-imidazol-4-ylidene>pentanoic acid methyl ester 在 palladium hydroxide - carbon 氢气 作用下， 以 乙酸乙酯 为溶剂， 反应 1.0h， 生成 <3aS-(3aα,4β,6aα)>-Hexahydro-2-oxo-1-(phenylmethyl)-1H-thieno<3,4-d>imidazole-4-pentanoic acid methyl ester
  参考文献：
  名称：

  Novel Enantioselective Syntheses of (+)-Biotin

  摘要：

  Two conceptually attractive enantioselective syntheses of(+)-biotin from L-cysteine are reported based upon an intramolecular 1,3-dipolar cycloaddition of a carbamoyl azide. The first approach (12 steps) involves the following as key-steps: (i) the macrothiolactonization of acid 10b to Z-olefin 14, (ii) the thermolysis of the ene carbamoyl azide 15 in water with direct formation of a mixture of the benzylated derivatives of(+)-biotin 16a and 17a. The second approach (14 steps) involves the following: (i) elimination of bromide 29 to the endocyclic thioenol ether 30, (ii) thermolysis of the ene carbamoyl azide 30 to the exocyclic thioenol ethers 31a and 31b. Both the synthesis of 29 and the final transformation of 31a and 31b into (+)-biotin are based upon literature precedents.

  DOI：

  10.1021/jo00107a009
• 作为产物：
  描述：

  <2S-(2α,3β,4α)>-3-Bromotetrahydro-4-<(phenylmethyl)amino>-2-thiophenepentanoic acid methyl ester 在 sodium azide 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 、 丙酮 为溶剂， 反应 41.0h， 生成 <3aS-(3aα,4E,6aα)>-5-imidazol-4-ylidene>pentanoic acid methyl ester
  参考文献：
  名称：

  Novel Enantioselective Syntheses of (+)-Biotin

  摘要：

  Two conceptually attractive enantioselective syntheses of(+)-biotin from L-cysteine are reported based upon an intramolecular 1,3-dipolar cycloaddition of a carbamoyl azide. The first approach (12 steps) involves the following as key-steps: (i) the macrothiolactonization of acid 10b to Z-olefin 14, (ii) the thermolysis of the ene carbamoyl azide 15 in water with direct formation of a mixture of the benzylated derivatives of(+)-biotin 16a and 17a. The second approach (14 steps) involves the following: (i) elimination of bromide 29 to the endocyclic thioenol ether 30, (ii) thermolysis of the ene carbamoyl azide 30 to the exocyclic thioenol ethers 31a and 31b. Both the synthesis of 29 and the final transformation of 31a and 31b into (+)-biotin are based upon literature precedents.

  DOI：

  10.1021/jo00107a009

文献信息

• Novel Enantioselective Syntheses of (+)-Biotin
  作者：Frederik D. Deroose、Pierre J. De Clercq

  DOI：10.1021/jo00107a009

  日期：1995.1

  Two conceptually attractive enantioselective syntheses of(+)-biotin from L-cysteine are reported based upon an intramolecular 1,3-dipolar cycloaddition of a carbamoyl azide. The first approach (12 steps) involves the following as key-steps: (i) the macrothiolactonization of acid 10b to Z-olefin 14, (ii) the thermolysis of the ene carbamoyl azide 15 in water with direct formation of a mixture of the benzylated derivatives of(+)-biotin 16a and 17a. The second approach (14 steps) involves the following: (i) elimination of bromide 29 to the endocyclic thioenol ether 30, (ii) thermolysis of the ene carbamoyl azide 30 to the exocyclic thioenol ethers 31a and 31b. Both the synthesis of 29 and the final transformation of 31a and 31b into (+)-biotin are based upon literature precedents.