2-(pyridin-2-yl)phenyl 3,4-dimethoxybenzoate | 1574184-80-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: 2-(pyridin-2-yl)phenyl 3,4-dimethoxybenzoate
• 英文别名: (2-Pyridin-2-ylphenyl) 3,4-dimethoxybenzoate；(2-pyridin-2-ylphenyl) 3,4-dimethoxybenzoate
• CAS: 1574184-80-7
• 化学式: C₂₀H₁₇NO₄
• 分子量: 335.359
• InChiKey: YQCLVZHKKWYCKP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  57.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-苯基吡啶 、 3,4-二甲氧基苯乙炔 在 叔丁基过氧化氢 、 copper diacetate 作用下， 以 癸烷 为溶剂， 反应 11.0h， 以75%的产率得到2-(pyridin-2-yl)phenyl 3,4-dimethoxybenzoate
  参考文献：
  名称：

  Terminal Aryl Alkenes and Alkynes as Arylcarboxy Surrogates toward o-Benzoxylation of 2-Phenylpyridine Catalyzed by Copper

  摘要：

  A variety of styrenes and phenylacetylenes serve as excellent arylcarboxy sources in bringing about substrate directed o-benzoxylation of 2-phenylpyridine derivatives catalyzed by Cu(II) in the presence of TBHP. This reaction proceeds via formation of phenylglyoxal followed by decarbonylation to benzoyl radical/benzaldehyde which acts as the arylcarboxy source.

  DOI：

  10.1021/ol500224e

文献信息

• Terminal Aryl Alkenes and Alkynes as Arylcarboxy Surrogates toward <i>o</i>-Benzoxylation of 2-Phenylpyridine Catalyzed by Copper
  作者：Saroj Kumar Rout、Srimanta Guin、Anupal Gogoi、Ganesh Majji、Bhisma K. Patel

  DOI：10.1021/ol500224e

  日期：2014.3.21

  A variety of styrenes and phenylacetylenes serve as excellent arylcarboxy sources in bringing about substrate directed o-benzoxylation of 2-phenylpyridine derivatives catalyzed by Cu(II) in the presence of TBHP. This reaction proceeds via formation of phenylglyoxal followed by decarbonylation to benzoyl radical/benzaldehyde which acts as the arylcarboxy source.