bis(m-nitrophenyl) hydrogen phosphate | 28022-29-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: bis(m-nitrophenyl) hydrogen phosphate
• 英文别名: bis-(m-nitrophenyl)phosphate；di(3-nitrophenyl)phosphate；Bis-3-nitrophenylhydrogenphosphat；Bis(3-nitrophenyl) hydrogen phosphate
• CAS: 28022-29-9
• 化学式: C₁₂H₉N₂O₈P
• 分子量: 340.186
• InChiKey: HXCJJXPPOQFCKC-UHFFFAOYSA-N

物化性质

• 沸点：
  511.7±60.0 °C(Predicted)
• 密度：
  1.614±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  147
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  bis(m-nitrophenyl) hydrogen phosphate 、 beta-胸苷 在 环丁砜 、 N,N'-二环己基碳二亚胺 作用下， 生成 thymidine 5'-
  参考文献：
  名称：

  Bis(m-nitrophenyl) and bis(p-nitrophenyl) esters and the phosphorodiamidate of thymidine 5'-phosphate as potential sources of intracellular thymidine 5'-phosphate in mouse cells in culture

  摘要：

  Thymidine 5'-phosphate (TMP) derivatives with masked phosphate groups were synthesized in tritiated form from [methyl-3H]thymidine. They were of interest as models for 5' nucleotide derivatives that might be able to permeate mammalian cells and then liberate intracellular antimetabolite 5' nucleotides by loss of the masking groups. Mouse L fibroblasts were grown in vitro in the presence of 1 mM 5'-amino-5'-deoxythymidine, which was found to suppress greater than 99% of cellular thymidine kinase activity while inhibiting the rate of cell division by only 30%. The TMP derivatives were less effective than thymidine in labeling the deoxyribonucleic acid (DNA) of the L cells. The labeling was inhibited 95-99% by 5'-amino-5'-deoxythymidine, indicating that it represented incorporation into DNA of [3H]thymidine formed from degradation of the test compounds. No evidence was obtained that the compounds acted as sources of intracellular TMP by cell permeation followed by loss of phosphate blocking groups. Similar studies yielded no evidence that the bis(m-nitrophenyl) ester of TMP produced intracellular TMP by that route in the LM(TK-) strain of L cells that are genetically deficient in thymidine kinase.

  DOI：

  10.1021/jm00378a036
• 作为产物：
  描述：

  间硝基苯酚 在 吡啶 、 三氯氧磷 作用下， 以 乙腈 为溶剂， 反应 14.0h， 以31%的产率得到bis(m-nitrophenyl) hydrogen phosphate
  参考文献：
  名称：

  静电增强磷酸：布朗斯台德酸催化中的工具

  摘要：

  报道了一种具有增强的反应性的新型磷酸催化剂。这些化合物具有一个或两个带正电的中心，这些中心会静电激活它们。包括弗里德-克拉夫茨（Friedel-Crafts）和狄尔斯-阿尔德（Diels-Alder）反应以及开环聚合在内的数个键形成转化对此进行了说明。观察到对应于数量级的速率加速度。

  DOI：

  10.1021/acs.orglett.6b02750

文献信息

• β-CYCLODEXTRIN PHOSPHATE. A REMARKABLE CATALYST FOR THE IODINE OXIDATION OF BENZYL METHYL SULFIDE TO THE SULFOXIDE IN WATER
  作者：Toshio Eiki、Waichiro Tagaki

  DOI：10.1246/cl.1980.1063

  日期：1980.8.5

  β-Cyclodextrin phosphate has been found to be a remarkable catalyst for the iodine oxidation of benzyl methyl sulfide to the sulfoxide in water.

  β-环糊精磷酸酯被发现是一种显著的催化剂，可以在水中将苄基甲基硫化物氧化为亚砜。
• The reactivity of phosphate esters. Diester hydrolysis
  作者：A. J. Kirby、M. Younas

  DOI：10.1039/j29700000510

  日期：——

  Phosphate diesters are, in general, exceedingly unreactive compounds, but their reactivity towards hydrolysis depends strongly on the basicity of the leaving group. As a result the difference in reactivity between diester and monoester monoanions decreases rapidly as the basicity of the leaving group decreases, and with very good leaving groups the reactivity of the two classes of compounds is comparable

  磷酸二酯通常是极不反应的化合物，但它们对水解的反应性在很大程度上取决于离去基团的碱性。结果，随着离去基团的碱性降低，二酯和单酯单阴离子之间的反应性差异迅速减小，并且对于非常好的离去基团，两类化合物的反应性相当。磷酸二酯阴离子的水解机理似乎涉及溶剂对磷的双分子亲核攻击。
• Method for producing meta type polyaniline
  申请人：Honda Giken Kogyo Kabushiki Kaisha

  公开号：EP1090944A2

  公开（公告）日：2001-04-11

  A novel method for producing a meta type polyaniline, comprising polymerizing aniline in at least one organic solvent selected from N-methyl-2-pyrrolidone, N,N-dimethyl sulfoxide, N,N-dimethylacetamide and N,N-dimethylformamide, in the presence of at least one oxidizing agent selected from ammonium peroxodisulfate, iron(III) chloride, manganese dioxide and hydrogen peroxide, at -20°C to 50°C.

  一种生产元型聚苯胺的新方法，包括在至少一种选自 N-甲基-2-吡咯烷酮、N,N-二甲基亚砜、N,N-二甲基乙酰胺和 N,N-二甲基甲酰胺的有机溶剂中，在至少一种选自过氧化二硫酸铵、氯化铁（III）、二氧化锰和过氧化氢的氧化剂存在下，于 -20°C 至 50°C 的温度下聚合苯胺。
• Proton conducting polymer, method for producing the same, solid polymer electrolyte and electrode
  申请人：Honda Giken Kogyo Kabushiki Kaisha

  公开号：EP1085034A1

  公开（公告）日：2001-03-21

  A proton conducting polymer obtained by blending an organic phosphoric acid compound solution with a meta type polyaniline solution; a solid polymer electrolyte for a fuel cell comprising the proton conducting polymer, which is excellent in proton conductivity, methanol barrier property and dopant stability in an aqueous solution of methanol; and an electrode comprising the proton conducting and fine catalyst particles carried on porous particles.

  一种质子传导聚合物，由有机磷酸化合物溶液与元型聚苯胺溶液混合而成；一种燃料电池用固体聚合物电解质，由质子传导聚合物组成，该聚合物在甲醇水溶液中具有优异的质子传导性、甲醇阻隔性和掺杂稳定性；以及一种电极，由质子传导聚合物和多孔颗粒上的细小催化剂颗粒组成。
• US6303053B1
  申请人：——

  公开号：US6303053B1

  公开（公告）日：2001-10-16