Vobasan-17-oic acid, 3-oxo-, methyl ester | 2134-83-0

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 沃巴桑生物碱
• 英文名称: Vobasan-17-oic acid, 3-oxo-, methyl ester
• 英文别名: methyl (1S,14R,15E)-15-ethylidene-17-methyl-12-oxo-10,17-diazatetracyclo[12.3.1.03,11.04,9]octadeca-3(11),4,6,8-tetraene-18-carboxylate
• CAS: 2134-83-0
• 化学式: C₂₁H₂₄N₂O₃
• 分子量: 352.4
• InChiKey: TYPMTMPLTVSOBU-RYHVKKFISA-N

物化性质

• 熔点：
  111-113 °C
• 沸点：
  526.8±50.0 °C(Predicted)
• 密度：
  1?+-.0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  62.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• IBOGAMINE CONGENERS
  申请人：ALBANY MEDICAL COLLEGE

  公开号：EP0859610B1

  公开（公告）日：2006-01-11
• VOACAMINE EN TANT QU'AGENT ANTI-PALUDEEN ET AGENT ANTI-PALUDEEN CONTENANT DE LA VOACAMINE
  申请人：Millenia Hope Inc.

  公开号：EP1067938A1

  公开（公告）日：2001-01-17
• IBOGAINE FORMULATIONS
  申请人：Caamtech, LLC

  公开号：EP3986415A1

  公开（公告）日：2022-04-27
• Use of voacamine and related compounds in the treatment of malaria
  申请人：Stella Leonard

  公开号：US20070032460A1

  公开（公告）日：2007-02-08

  Voacamine, voacamine isomers, metabolites and derivatives, and related compounds can be used to, in effect, reverse multi-drug resistance in malaria and are non-toxic. The compounds can be used in combination with known drugs such as chloroquine, arthemesin and qinghaosu to prevent or treat malaria.
• Anti-parasitic and/or anti-viral and/or anti-microbial compositions
  申请人：Stella Leonard

  公开号：US20070232588A1

  公开（公告）日：2007-10-04

  Voacamine and its natural and synthetic derivatives such as 16′-decarbometheoxyvoacamine, N 6 -demethylvoacamine, voacamidine, tabernamine, ervahamine A, vobasine and coronaridine are useful as anti-microbial, anti-parasitic and anti-viral agents. A basic extract of the tertiary alkaloids present in plants of the genus Peschiera or Voacanga , especially Peschiera fuchsiaefolia can be isolated and used directly as such an agent.