trimethyl(isopentyloxy)silane | 18246-56-5

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: trimethyl(isopentyloxy)silane
• 英文别名: trimethylsilyl 3-methyl-1-butyl ether；isopentyl trimethylsilyl ether；trimethyl-(3-methyl-butoxy)-silane；3-methyl-1-trimethylsilanyloxy-butane；isopentyloxy-trimethyl-silane；Isopentyloxy-trimethyl-silan；Silane, (isopentyloxy)trimethyl-；trimethyl(3-methylbutoxy)silane
• CAS: 18246-56-5
• 化学式: C₈H₂₀OSi
• 分子量: 160.332
• InChiKey: ZYQPBYVVLYYAQX-UHFFFAOYSA-N

物化性质

• 保留指数：
  853.4;842.2

计算性质

• 辛醇/水分配系数(LogP)：
  2.88
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  trimethyl(isopentyloxy)silane 生成 1-氟-3-甲基丁烷
  参考文献：
  名称：

  Une evaluation du

  摘要：

  DOI：

  10.1016/s0040-4020(01)83214-2
• 作为产物：
  描述：

  异戊醇 以9%的产率得到
  参考文献：
  名称：

  KROLEVETS, A. A.;ANTIPOVA, V. V.;POPOV, A. G.;ADAMOV, A. V., ZH. OBSHCH. XIMII, 58,(1988) N 10, S. 2274-2281

  摘要：

  DOI：

文献信息

• 1,3-Dichloro-5,5-Dimethylhydantoin (DCH) and Trichloromelamine (TCM) as Efficient Catalysts for the Chemoselective Trimethylsilylation of Hydroxyl Group with 1,1,1,3,3,3-Hexamethyldisilazane (HMDS) Under Mild Conditions
  作者：Arash Ghorbani-Choghamarani、Kamal Amani、Mohammad Ali Zolfigol、Maryam Hajjami、Roia Ayazi-Nasrabadi

  DOI：10.1002/jccs.200900037

  日期：2009.4

  A highly convenient method for the trimethylsilylation of alcohols and phenols via treatment by hexamethyldisilazane in the presence of 1,3–dichloro‐5,5–dimethylhydantoin (DCH) and/or trichloromelamine (TCM) as a catalyst has been developed. A wide variety of hydroxyl groups were selectively protected in CH2Cl2/CH3CN under mild conditions.

  已经开发了一种非常方便的方法，用于在1，3-二氯-5，5-二甲基乙内酰脲（DCH）和/或三氯三聚氰胺（TCM）作为催化剂存在下，通过六甲基二硅氮烷进行处理，对醇和酚进行三甲基甲硅烷基化。在温和的条件下，在CH 2 Cl 2 / CH 3 CN中选择性保护了多种羟基。
• A Mild, Simple, Efficient, and Selective Protection of Hydroxyl Groups Using Silica-Supported Sodium Hydrogen Sulfate as a Heterogeneous Catalyst
  作者：Hamid Reza Shaterian、Razieh Doostmohammadi、Majid Ghashang、Mashaallah Rahmani

  DOI：10.1080/10426500802066054

  日期：2008.11.7

  A mild, simple, novel, and highly efficient method for the rapid protection of various primary, secondary, tertiary aliphatic alcohols, aromatic alcohols, and oximes using hexamethyldisilazane (HMDS) in the presence of silica-supported sodium hydrogen sulfate (NaHSO 4 -SiO 2 ), as an active, inexpensive, nontoxic, heterogeneous, and readily available catalyst under ambient conditions is described.

  一种温和、简单、新颖且高效的方法，可在二氧化硅负载的硫酸氢钠 (NaHSO 4 -SiO) 存在下使用六甲基二硅氮烷 (HMDS) 快速保护各种伯、仲、叔脂肪醇、芳香醇和肟2 )，描述了在环境条件下作为活性、廉价、无毒、非均相和容易获得的催化剂。在室温下温和且几乎中性的反应条件下，以高产率制备三甲基甲硅烷基醚，反应时间短。
• A Highly Efficient Method for the Silylation of Alcohols, Phenols, and Naphthols Using HMDS in the Presence of Zinc Oxide (ZnO) as Economical Heterogeneous Catalyst
  作者：Hamid Reza Shaterian、Majid Ghashang

  DOI：10.1080/10426500701569406

  日期：2007.12.24

  Variety alcohols, phenols, and naphthols were effectively converted into their corresponding trimethylsilyl ether with hexamethyldisilazane in the presence of zinc oxide under very mild and ambient conditions with short reaction time in good to excellent yields.

  在氧化锌的存在下，在非常温和的环境条件下，各种醇类、酚类和萘酚类与六甲基二硅氮烷一起有效转化为相应的三甲基甲硅烷基醚，反应时间短，收率良好。
• Zinc Mediated Reactions in Organic Synthesis: Efficient Synthesis of Silyl Ethers under Mild Conditions
  作者：Babasaheb Pandurang Bandgar、Satish Navnath Chavare、Shivaji Sandu Pandit

  DOI：10.1002/jccs.200500019

  日期：2005.2

  General and practical method for the synthesis of silyl ethers in the presence of zinc powder under mild conditions has been described.

  描述了在温和条件下在锌粉存在下合成甲硅烷基醚的一般实用方法。
• Efficient and practical protocol for silylation of hydroxyl groups using reusable lithium perchlorate dispread in silica gel under neutral condition
  作者：Najmedin Azizi、Rozbeh Yousefi、Mohammad R. Saidi

  DOI：10.1016/j.jorganchem.2005.11.005

  日期：2006.2

  for the trimethylsilylation of a wide variety of alcohols, including primary, allylic, benzylic, secondary, hindered secondary, tertiary, and phenols with hexamethyldisilazane on the surface of silica gel dispersed with LiClO4 in room temperature at few minutes in excellent yields under neutral conditions is reported. This procedure also allows the excellent selectivity under LP-SiO2 system for silylation

  在室温下几分钟内，用六甲基二硅氮烷在六氯二硅氮烷上分散含有LiClO 4的硅胶表面上的多种醇，包括伯，烯丙基，苄基，仲，受阻仲，叔和苯酚的三甲基甲硅烷基化反应，非常高效，温和据报道在中性条件下产量极高。该方法还允许在存在胺和酚羟基的情况下在LP-SiO 2系统下对醇进行甲硅烷基化具有优异的选择性。

表征谱图