4-Chlorobenzo[d]isoxazole | 1260783-81-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并异恶唑
• 英文名称: 4-Chlorobenzo[d]isoxazole
• 英文别名: 4-chloro-1,2-benzoxazole
• CAS: 1260783-81-0
• 化学式: C₇H₄ClNO
• 分子量: 153.56
• InChiKey: KIDRAJFMFLDKDJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  26
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] METHOD FOR MANUFACTURING A BORONIC ACID ESTER COMPOUND<br/>[FR] PROCÉDÉ POUR LA FABRICATION D'UN COMPOSÉ ESTER DE L'ACIDE BORONIQUE
  申请人：SUMITOMO CHEMICAL CO

  公开号：WO2010110782A1

  公开（公告）日：2010-09-30

  The present invention relates to a method for manufacturing a boronic acid ester compound, characterized by reacting an aryl halide compound and a diboron ester compound in the presence of a nitrogen-containing organic base, a nickel catalyst, a phosphine compound and a solvent. According to the manufacturing method of the present invention, even if a nickel catalyst is used as the catalyst, a desired boronic acid ester compound can be obtained in a sufficiently high yield. Furthermore, even if aryl chloride or aryl bromide having relatively low price and low reactivity, was used as the aryl halide compound, a desired boronic acid ester compound can be obtained in a sufficiently high yield.

  本发明涉及一种制造硼酸酯化合物的方法，其特征在于在氮含有机碱、镍催化剂、膦化合物和溶剂的存在下，将芳基卤化物化合物和二硼酯化合物反应。根据本发明的制造方法，即使使用镍催化剂作为催化剂，也可以获得所需的硼酸酯化合物，并且收率足够高。此外，即使使用价格相对较低且反应性较低的芳基氯化物或芳基溴化物作为芳基卤化物化合物，也可以获得所需的硼酸酯化合物，并且收率足够高。
• METHOD FOR MANUFACTURING A BORONIC ACID ESTER COMPOUND
  申请人：Miki Takashi

  公开号：US20120123122A1

  公开（公告）日：2012-05-17

  The present invention relates to a method for manufacturing a boronic acid ester compound, characterized by reacting an aryl halide compound and a diboron ester compound in the presence of a nitrogen-containing organic base, a nickel catalyst, a phosphine compound and a solvent. According to the manufacturing method of the present invention, even if a nickel catalyst is used as the catalyst, a desired boronic acid ester compound can be obtained in a sufficiently high yield. Furthermore, even if aryl chloride or aryl bromide having relatively low price and low reactivity, was used as the aryl halide compound, a desired boronic acid ester compound can be obtained in a sufficiently high yield.

  本发明涉及一种制备硼酸酯化合物的方法，其特征在于在氮含有机碱、镍催化剂、膦化合物和溶剂的存在下，将芳基卤化物化合物和二硼酯化合物反应。根据本发明的制造方法，即使使用镍催化剂作为催化剂，也可以获得所需的硼酸酯化合物，产率足够高。此外，即使使用价格较低且反应性较低的芳基氯化物或芳基溴化物作为芳基卤化物化合物，也可以获得所需的硼酸酯化合物，产率足够高。
• Isoxazole derivatives for use as cerebro-active drugs and central muscle relaxants
  申请人：Sankyo Company Limited

  公开号：EP0335723B1

  公开（公告）日：1991-12-04
• 3-Isoxazolone derivatives, their preparation and their therapeutic uses
  申请人：Sankyo Company Limited

  公开号：EP0420464B1

  公开（公告）日：1994-07-13
• US5321037A
  申请人：——

  公开号：US5321037A

  公开（公告）日：1994-06-14