5-[(4-methoxyphenyl)(phenyl)methyl]-2-(methylamino)benzoic acid | 1443414-05-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 5-[(4-methoxyphenyl)(phenyl)methyl]-2-(methylamino)benzoic acid
• 英文别名: 5-[(4-Methoxyphenyl)-phenylmethyl]-2-(methylamino)benzoic acid；5-[(4-methoxyphenyl)-phenylmethyl]-2-(methylamino)benzoic acid
• CAS: 1443414-05-8
• 化学式: C₂₂H₂₁NO₃
• 分子量: 347.414
• InChiKey: VBUYNSRKTPUUKP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-甲氧基二苯甲醇 、 N-甲基蒽 在 sodium tetrachloroaurate(III) dihyrate 、 sodium 3-(diphenylphosphanyl)benzenesulfonate 作用下， 以 水 为溶剂， 反应 24.0h， 以86%的产率得到5-[(4-methoxyphenyl)(phenyl)methyl]-2-(methylamino)benzoic acid
  参考文献：
  名称：

  Chemoselective Benzylation of Unprotected Anthranilic Acids with Benzhydryl Alcohols by Water-Soluble Au(III)/TPPMS in Water

  摘要：

  A novel and efficient method for the benzylation of unprotected anthranilic acids with benzhydryl alcohols using water-soluble Au(III)/TPPMS in water is developed. Water plays an important role in our catalytic system. This new protocol could be used for not only N-benzylation, but also chemoselective C-benzylation by the Friedel-Crafts reaction.

  DOI：

  10.1021/jo401064f

文献信息

• Chemoselective Benzylation of Unprotected Anthranilic Acids with Benzhydryl Alcohols by Water-Soluble Au(III)/TPPMS in Water
  作者：Hidemasa Hikawa、Hideharu Suzuki、Yuusaku Yokoyama、Isao Azumaya

  DOI：10.1021/jo401064f

  日期：2013.7.5

  A novel and efficient method for the benzylation of unprotected anthranilic acids with benzhydryl alcohols using water-soluble Au(III)/TPPMS in water is developed. Water plays an important role in our catalytic system. This new protocol could be used for not only N-benzylation, but also chemoselective C-benzylation by the Friedel-Crafts reaction.