3-Acetyl-8-methoxy-2H-cyclohepta[b]furan-2-one | 1210-38-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 环七呋喃
• 英文名称: 3-Acetyl-8-methoxy-2H-cyclohepta[b]furan-2-one
• 英文别名: 3-acetyl-8-methoxycyclohepta[b]furan-2-one
• CAS: 1210-38-4
• 化学式: C₁₂H₁₀O₄
• 分子量: 218.209
• InChiKey: CIAFGDINQLNVQF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,5-二甲氧基-2,5-二氢呋喃 、 3-Acetyl-8-methoxy-2H-cyclohepta[b]furan-2-one 以48%的产率得到Methyl 2-(1-acetyl-4-methoxyazulen-2-yl)acetate
  参考文献：
  名称：

  A Convenient, One-Pot Synthesis of Azulenes Having Versatile Functional Groups by the Reaction of 2H-Cyclohepta[b]furan-2-ones with Furan Derivatives

  摘要：

  2-Acylmethyl- and 2-methoxycarbonylmethylazulene derivatives having versatile functional groups in the side chain, are synthesized in one-pot by the reaction of 2H-cyclohepta[b]furan-2-ones with furans on heating at 160-190-degrees-C in aprotic solvent.

  DOI：

  10.3987/com-91-5936

文献信息

• A Convenient, One-Pot Synthesis of Azulenes Having Versatile Functional Groups by the Reaction of 2H-Cyclohepta[b]furan-2-ones with Furan Derivatives
  作者：Hidetsugu Wakabayashi、Paw-Wang Yang、Chi-Phi Wu、Kimio Shindo、Sumio Ishikawa、Tetsuo Nozoe

  DOI：10.3987/com-91-5936

  日期：——

  2-Acylmethyl- and 2-methoxycarbonylmethylazulene derivatives having versatile functional groups in the side chain, are synthesized in one-pot by the reaction of 2H-cyclohepta[b]furan-2-ones with furans on heating at 160-190-degrees-C in aprotic solvent.