4'-{(2-hydroxyethyl)(methyl)amino}-4-nitroazobenzene | 41616-43-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 偶氮苯
• 英文名称: 4'-{(2-hydroxyethyl)(methyl)amino}-4-nitroazobenzene
• 英文别名: disperse red one；2-[N-methyl-4-(4-nitro-phenylazo)-anilino]-ethanol；2-[N-Methyl-4-(4-nitro-phenylazo)-anilino]-aethanol；4--4'-nitroazobenzol；Ethanol, 2-[methyl[4-[(4-nitrophenyl)azo]phenyl]amino]-；2-[N-methyl-4-[(4-nitrophenyl)diazenyl]anilino]ethanol
• CAS: 41616-43-7
• 化学式: C₁₅H₁₆N₄O₃
• 分子量: 300.317
• InChiKey: OGNIUIINDXCOTE-UHFFFAOYSA-N

物化性质

• 沸点：
  514.9±45.0 °C(Predicted)
• 密度：
  1.25±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  94
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4'-{(2-hydroxyethyl)(methyl)amino}-4-nitroazobenzene 在 吡啶 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 生成
  参考文献：
  名称：

  Real-Time Measurements of Protein Dynamics Using Fluorescence Activation-Coupled Protein Labeling Method

  摘要：

  We present a fluorescence activation-coupled protein labeling (FAPL) method, which employs small-molecular probes that exhibit almost no basal fluorescence but acquire strong fluorescence upon covalent binding to tag-proteins. This method enables real-time imaging of protein labeling without any washout process and is uniquely suitable for real-time imaging of protein dynamics on the cell surface. We applied this method to address the spatiotemporal dynamics of the EGF receptor during cell migration.

  DOI：

  10.1021/ja200225m
• 作为产物：
  描述：

  4-硝基苯胺 、 2-[(4-amino-phenyl)-methyl-amino]-ethanol 生成 4'-{(2-hydroxyethyl)(methyl)amino}-4-nitroazobenzene
  参考文献：
  名称：

  171.在叔胺存在下，αβ-不饱和酰氯与醇反应

  摘要：

  DOI：

  10.1039/jr9640000883

文献信息

• Synthesis of double-conjugated-segment molecules and their application as ultra-broad two-photon-absorption optical limiters
  作者：Junxiang Zhang、Yiping Cui、Mingliang Wang、Juzheng Liu

  DOI：10.1039/b208190c

  日期：2002.10.18

  A series of novel double-conjugated-segment molecules, in which two conjugated segments are separated by an ether chain, were synthesized; these compounds provide a very broad two-photon absorption spectral range, which satisfies an urgent need in the optical limiting area.

  合成了一系列新型双共轭段分子，其中两个共轭段由醚链分隔，这些化合物提供了非常宽的双光子吸收光谱范围，满足了光学限幅领域内的迫切需求。
• Synthesis and Characterization of a Series of Azobenzene-Containing Side-Chain Liquid Crystalline Polymers
  作者：Stephan Freiberg、François Lagugné-Labarthet、Paul Rochon、Almeria Natansohn

  DOI：10.1021/ma021384b

  日期：2003.4.1

  of the side-chain mesogens since the smectic layer spacing was larger than a fully extended side chain but less than two extended chains. This behavior is confirmed by temperature dependent aggregation as observed by UV−visible spectroscopy during the transition from an amorphous state to a liquid crystalline phase. The stability of the mesophase is enhanced by intermolecular interactions as argued

  一系列具有液晶（LC）性质的聚4'-（X-甲基丙烯酰氧基亚烷基）甲基氨基} -4-硝基偶氮苯}（p X MAN，其中X是亚甲基单元的数目，范围为2至12）。合成的。当退火至高于其T g时值，整个系列的聚合物表现出稳定的近晶A中间相，而只有间隔更短的材料p2MAN呈现近晶相，随后是向列相。通过X射线衍射确定近晶层的间距，因为近晶层的间距大于完全延伸的侧链但小于两条延伸的链，所以通过侧链介晶的叉指显示分子间的重组。这种行为通过从紫外到可见光谱从非晶态到液晶相转变过程中观察到的温度依赖性聚集得到了证实。中间相的稳定性通过分子间的相互作用得到增强，如焓和热致变色方面的考虑。
• Multichromophoric Calix[4]arenes: Effect of Interchromophore Distances on Linear and Nonlinear Optical Properties
  作者：Raquel Andreu、Santiago Franco、Javier Garín、Judith Romero、Belén Villacampa、María Jesús Blesa、Jesús Orduna

  DOI：10.1002/cphc.201200203

  日期：2012.9.17

  Multichromophoric calix[4]arenes with two or four disperse red one (DR1) moieties linked to the lower rim have been synthesized. The second‐order nonlinear optical activity was measured by using the electric‐field‐induced second‐harmonic generation technique and there was a nearly linear increase of the μβ value with the number of chromophores in the molecule without affecting the charge‐transfer absorption

  已合成了具有两个或四个与下边缘连接的分散红一（DR1）部分的多色杯[4]芳烃。使用电场诱导的二次谐波产生技术测量了二次非线性光学活性，并且在不影响电荷转移吸收波长的情况下，μβ值随分子中发色团的数量几乎呈线性增加。还使用量子化学计算研究了DR1单元数目对超极化性，偶极矩和吸收最大值的影响。发现有必要将多发色团与远处的发色团合成以获得较大的非线性光学响应。
• CN115521329
  申请人：——

  公开号：——

  公开（公告）日：——
• Real-Time Measurements of Protein Dynamics Using Fluorescence Activation-Coupled Protein Labeling Method
  作者：Toru Komatsu、Kai Johnsson、Hiroyuki Okuno、Haruhiko Bito、Takanari Inoue、Tetsuo Nagano、Yasuteru Urano

  DOI：10.1021/ja200225m

  日期：2011.5.4

  We present a fluorescence activation-coupled protein labeling (FAPL) method, which employs small-molecular probes that exhibit almost no basal fluorescence but acquire strong fluorescence upon covalent binding to tag-proteins. This method enables real-time imaging of protein labeling without any washout process and is uniquely suitable for real-time imaging of protein dynamics on the cell surface. We applied this method to address the spatiotemporal dynamics of the EGF receptor during cell migration.