1,2,3,4,6,7,8,9-Octahydropyrimido[1,2-a]azepine | 57516-77-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吖庚因类
• 英文名称: 1,2,3,4,6,7,8,9-Octahydropyrimido[1,2-a]azepine
• CAS: 57516-77-5
• 化学式: C₉H₁₆N₂
• 分子量: 152.24
• InChiKey: LRAUXUFJZIWABJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Hepatitis C Virus Inhibitors
  申请人：Wang Alan Xiangdong

  公开号：US20090304626A1

  公开（公告）日：2009-12-10

  Hepatitis C virus inhibitors having the general formula are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

  揭示了具有一般公式的丙型肝炎病毒抑制剂。还揭示了包含这些化合物的组合物和使用这些化合物抑制HCV的方法。
• [EN] MK2 INHIBITORS, SYNTHESIS THEREOF, AND INTERMEDIATES THERETO<br/>[FR] INHIBITEURS DE MK2, LEUR SYNTHÈSE ET LEURS INTERMÉDIAIRES
  申请人：CELGENE CAR LLC

  公开号：WO2018170203A1

  公开（公告）日：2018-09-20

  The present invention provides methods of preparing a MK2 inhibitor, and intermediates related thereto.

  本发明提供了制备MK2抑制剂及相关中间体的方法。
• Benzophenone hydrazone derivatives as insecticides
  申请人：NIHON BAYER AGROCHEM K.K.

  公开号：EP0742202A2

  公开（公告）日：1996-11-13

  Summary Of The Invention Novel benzophenonehydrazone derivatives represented by the formula (I): wherein, R1 is halogen; R2 is hydrogen or C1-4 alkyl; R3 is cyano, optically substituted C1-4 alkyl, C2-4 alkenyl, C3-4 alkynyl, C1-4 alkyl-carbonyl or C1-4 alkoxy-thiocarbonyl; R4 is hydrogen, phenyl, optionally substituted C1-6 alkyl, optionally substituted C2-8 alkenyl, -CO-R8, -CO-O-R9 or R5 is hydrogen, formyl, phenyl, optionally substituted C1-8 alkyl, optionally substituted C2-8 alkenyl, optionally substituted C3-8 alkynyl, optionally substituted C1-8 alkyl-carbonyl, optionally substituted C1-6 alkyl-oxalyl, optionally substituted C1-8 alkoxy-carbonyl, optionally substituted C1-8 alkoxy-oxalyl, optionally substituted C3-8 cycloalkyl-carbonyl, optionally substituted C2-8 alkenyl-carbonyl or optionally substituted benzoyl; R6 is hydrogen or halogen; R7 is hydrogen, halogen or C1-2 alkyl, C1-4 alkyl-carbonyl or C1-4 alkoxy-thiocarbonyl; n is 0, 1 or 2, provided that n is 0 when R3 is cyano, C1-4 alkyl-carbonyl or C1-4 alkoxy-thiocarbonyl, is a single bond of Anti form or of Syn form. The benzophenonehydrazone derivatives of the formula (I) have excellent insecticidal activities.

  发明概述 由式(I)代表的新型二苯甲酮腙衍生物： 其中，R1 是卤素；R2 是氢或 C1-4 烷基；R3 是氰基、被光学取代的 C1-4 烷基、C2-4 烯基、C3-4 炔基、C1-4 烷基-羰基或 C1-4 烷氧基-硫代羰基；R4 是氢、苯基、任选取代的 C1-6 烷基、任选取代的 C2-8 烯基、-CO-R8、-CO-O-R9 或 R5 是氢、甲酰基、苯基、任选取代的 C1-8 烷基、任选取代的 C2-8 烯基、任选取代的 C3-8 烷炔基、任选取代的 C1-8 烷基-羰基、任选取代的 C1-6 烷基-氧羰基、任选取代的 C1-8 烷氧基-羰基、任选取代的 C1-8 烷氧基-氧羰基、任选取代的 C3-8 环烷基-羰基、任选取代的 C2-8 烯基-羰基或任选取代的苯甲酰基；R6是氢或卤素；R7是氢、卤素或C1-2烷基、C1-4烷基-羰基或C1-4烷氧基-硫代羰基；n是0、1或2，但当R3是氰基、C1-4烷基-羰基或C1-4烷氧基-硫代羰基时，n为0，是Anti形式或Syn形式的单键。 式（I）的二苯甲酮腙衍生物具有优异的杀虫活性。
• Chloropyridylcarbonyl derivatives and their use as microbiocides
  申请人：NIHON BAYER AGROCHEM K.K.

  公开号：EP0763530A1

  公开（公告）日：1997-03-19

  Novel chloropyridylcarbonyl derivatives of the formula in which Hetis nis 1 or 2, R1is hydrogen, optionally substituted C1-6 alkyl, optionally substituted C2-6 alkenyl, optionally substituted C3-6 alkynyl, optionally substituted phenyl or optionally substituted pyrimidinyl, and R2 and R3,independently of each other, are hydrogen or C1-4 alkyl, and acid addition salts and metal salt complexes thereof, processes for the preparation of the new compounds and their use as microbicides.

  式中的新型氯吡啶羰基衍生物 其中 Hetis 为 1 或 2、 R1 是氢、任选取代的 C1-6 烷基、任选取代的 C2-6 烯基、任选取代的 C3-6 烷炔基、任选取代的苯基或任选取代的嘧啶基，以及 R2 和 R3 相互独立地为氢或 C1-4 烷基、 及其酸加成盐和金属盐络合物、 新化合物的制备工艺及其作为杀微生物剂的用途。
• 1,2,3-Benzothiadiazole derivatives and their use as microbicides
  申请人：NIHON BAYER AGROCHEM K.K.

  公开号：EP0816363A1

  公开（公告）日：1998-01-07

  1,2,3-Benzothiadiazole derivatives of the formula in which Het is and acid addition salts and metal salt complexes thereof, processes for the preparation of the new compounds and their use as microbicides. Intermediates of the formulae

  式中的 1,2,3-苯并噻二唑衍生物 其中 Het 为 及其酸加成盐和金属盐络合物、 新化合物的制备工艺及其作为杀微生物剂的用途。 式中的中间体