2-[1-(tert-butylamino)ethylidene]-5,5-dimethylcyclohexane-1,3-dione

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 乙烯基酰胺
• 英文名称: 2-[1-(tert-butylamino)ethylidene]-5,5-dimethylcyclohexane-1,3-dione
• 化学式: C₁₄H₂₃NO₂
• 分子量: 237.34
• InChiKey: NPVVIBMEOSRGBB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• TRACELESS REDUCTIVELY CLEAVABLE LINKER MOLECULES FOR PEPTIDE PURIFICATION
  申请人：BELYNTIC GMBH

  公开号：US20210332082A1

  公开（公告）日：2021-10-28

  The present invention relates to linker molecules of formula (1), X-T b -V a —U—Y—Z (1) and a method for purifying peptides using said linker molecules. The linker molecule can be coupled to a purification resin via the moiety X and to a peptide via the moiety Y under the release of the leaving group Z. T is an optional spacer moiety and V is an optional electron withdrawing moiety. U is an aryl or 5- or 6-membered heteroaryl moiety bound to at least one electron withdrawing moiety V, W or E. The linker is stable under acidic conditions and releases the peptide upon addition of a reducing agent.