N-(3-chlorophenyl)-6-(dichloromethyl)-1,3,5-triazine-2,4-diamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: N-(3-chlorophenyl)-6-(dichloromethyl)-1,3,5-triazine-2,4-diamine
• 英文别名: 2-N-(3-chlorophenyl)-6-(dichloromethyl)-1,3,5-triazine-2,4-diamine
• 化学式: C₁₀H₈Cl₃N₅
• mdl: MFCD05860579
• 分子量: 304.6
• InChiKey: WPPOQZKUEJTKRG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  76.7
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE
  申请人：Deshaies Raymond J.

  公开号：US20110288082A1

  公开（公告）日：2011-11-24

  Compounds of Formulas I-XLIII are identified as direct inhibitors of p97 ATPase or of the degradation of a p97-dependent ubiquitin-proteasome system (UPS) substrate. Methods and compositions are disclosed for inhibiting p97 ATPase and the degradation of a p97-dependent UPS substrate, and for identifying inhibitors thereof
• US8865708B2
  申请人：——

  公开号：US8865708B2

  公开（公告）日：2014-10-21
• [EN] METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE<br/>[FR] MÉTHODES ET COMPOSITIONS POUR L'INHIBITION DE L'ATPASE TRANSITIONNELLE DU RÉTICULUM ENDOPLASMIQUE
  申请人：CALIFORNIA INST OF TECHN

  公开号：WO2011140527A2

  公开（公告）日：2011-11-10

  Compounds of Formulas I-XLIII are identified as direct inhibitors of p97 ATPase or of the degradation of a p97-dependent ubiquitin-proteasome system (UPS) substrate. Methods and compositions are disclosed for inhibiting p97 ATPase and the degradation of a p97-dependent UPS substrate, and for identifying inhibitors thereof.